Cation-chloride cotransport mediated by an ion pair transporter

Abstract

Ion transport mediated by an ion pair receptor 1 bearing both cation and anion binding sites was presented. The ion pair binding property was revealed by means of 1H NMR...

Hydrophobic cyclic dipeptides as M+/Cl−carriers

“…While these dipeptides are less efficient than the crown-ether macrocycles reported 22,26 (EC 50 = 0.04 mol% and 0.45 mol%), their activity is comparable to the acyclic NH scaffolds with crown ethers, 23 and calixpyrrole derivatives, 24 better than the triazine derivative. 25 Also, to the best of our knowledge, this is the first peptide derived ion-pair carrier.…”

“…23 Alternatively, calix [4]pyrrole scaffolds with oligoether groups transport CsCl and RbCl, wherein the macrocycle presents the anion-binding domain. 25 Thiourea crown ether conjugates are also known to transport NaCl and KCl. 26 Common design elements in these molecules are crown ether based cation-binding sites and NH derived anion binding sites.…”

Exploiting the Mechanical Bond Effect for Enhanced Molecular Recognition and Sensing

“…These include salt extraction for precious metal mining, [101,102] lithium salt recovery for battery development and sustainability, [103][104][105] environmental cleansing/remediation of anthropogenically polluted water [2,3] and membrane transport of sodium and potassium salts for biomedical applications. [106][107][108][109] Heteroditopic receptors are commonly of acyclic or macrocyclic receptor design, where proximal recognition sites for the ion-pair gives rise to superior binding affinities for the binding of one ion upon association of the other, known as positive cooperativity. Typically, such cooperativity can be rationalized through the inherent favorable Coulombic attraction between the oppositely charged co-bound ions, [110][111][112] and/or positive allosteric effects wherein the binding of one ion induces a conformational change which augments the binding of the counter-ion.…”