Cathodic activation and inflammatory species are critical to simulating in vivo Ti-6Al-4V selective dissolution

Kurtz, Michael A.; Khullar, Piyush; Gilbert, Jeremy

doi:10.1016/j.actbio.2022.07.020

Cited by 19 publications

(17 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following the dissolution of the β , α is subsequently dissolved. Previous studies within our lab and others show that the combination of inflammatory species and cathodic activation can reproduce key characteristics of this damage in vitro 23,28 . In these simulated crevice corrosion conditions, β dissolution begins as small pits at the phase boundaries between β and α before continuing over time until all β is dissolved from the surface.…”

Section: Discussionmentioning

confidence: 81%

“…Previous studies within our lab and others show that the combination of inflammatory species and cathodic activation can reproduce key characteristics of this damage in vitro. 23,28 In these simulated crevice corrosion conditions, β dissolution begins as small pits at the phase boundaries between β and α before continuing over time until all β is dissolved from the surface. This preferential dissolution initiated at the phase boundaries indicates that the protective oxide structure over α may differ from oxide over β. Interphase boundary regions contain greater disorder and crystallographic defects, which may further promote corrosion.…”

Section: Discussionmentioning

confidence: 99%

“…While recent in vitro studies show that sustained cathodic activation and reactive oxygen species (ROS) induce selective dissolution of the Ti‐6Al‐4V β phase, crevice corrosion damage modes remain poorly understood. Additionally, fretting at the modular taper junction between Ti‐6Al‐4V stems and cobalt or ceramic heads is an ongoing concern 6,23–29 . Thus, documented in vivo corrosion modes of Ti‐6Al‐4V raise questions about alternative titanium alloys and their performance in ROS containing solutions.…”

Section: Introductionmentioning

confidence: 99%

“…The rationale for replacing Ti‐6Al‐4V has historically centered on published literature of vanadium ion cytotoxicity at the device interface and generating an alloy with a lower modulus to mitigate stress shielding 39,40 . While vanadium ion cytotoxicity has proven to be a non‐issue, in vitro studies show that the Ti‐6Al‐4V α – β phase boundaries are susceptible to corrosion when exposed to cathodic activation and ROS 23,41 . Thus, the equiaxed α + β microstructure, originally optimized for fatigue crack initiation resistance, exhibits diminished corrosion resistance when subjected to adverse electrochemical conditions within the confines of a crevice 7,11 …”

Section: Introductionmentioning

confidence: 99%

“…Additionally, fretting at the modular taper junction between Ti-6Al-4V stems and cobalt or ceramic heads is an ongoing concern. 6,[23][24][25][26][27][28][29] Thus, documented in vivo corrosion modes of Ti-6Al-4V raise questions about alternative titanium alloys and their performance in ROS containing solutions.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Additively manufactured Ti‐29Nb‐21Zr shows improved oxide polarization resistance versus Ti‐6Al‐4V in inflammatory simulating solution

Kurtz

Wessinger

Mace

et al. 2023

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

Retrieval studies in the past two decades show severe corrosion of titanium and its alloys in orthopedic implants. This damage is promoted by mechanically assisted crevice corrosion (MACC), particularly within modular titanium‐titanium junctions. During MACC, titanium interfaces may be subject to negative potentials and reactive oxygen species (ROS), generated from cathodic activation and/or inflammation. Additive manufacturing (AM) may be able to produce new, corrosion‐resistant titanium alloys and admixtures that are less susceptible to these adverse electrochemical events. In this study, we characterize the impedance and corrosion properties of three new AM titanium materials, including Ti‐6Al‐4V with added 1% nano‐yttria stabilized ZrO2, admixed Ti‐29Nb‐21Zr, and pre‐alloyed Ti‐29Nb‐21Zr. We aim to elucidate how these materials perform when subjected to high ROS solutions. We include conventionally and additively manufactured Ti‐6Al‐4V in our study as comparison groups. A 0.1 M H2O2 phosphate‐buffered saline (PBS) solution, simulating inflammatory conditions, significantly increased biomaterial OCP (−0.14 V vs. Ag/AgCl) compared to PBS only (−0.38 V, p = .000). During anodic polarization, Ti‐6Al‐4V passive current density more than doubled from 1.28 × 10−7 to 3.81 × 10−7 A/cm2 when exposed to 0.1 M H2O2. In contrast, Ti‐29Nb‐21Zr passive current density remained relatively unchanged, slightly increasing from 7.49 × 10−8 in PBS to 9.31 × 10−8 in 0.1 M H2O2. Ti‐29Nb‐21Zr oxide polarization resistance (Rp) was not affected by 0.1 M H2O2, maintaining a high value (1.09 × 106 vs. 1.89 × 106 Ω cm2), while Ti‐6Al‐4V in 0.1 M H2O2 solution had significantly diminished Rp (4.38 × 106 in PBS vs. 7.24 × 104 Ω cm2 in H2O2). These results indicate that Ti‐29Nb‐21Zr has improved corrosion resistance in ROS containing solutions when compared with Ti‐6Al‐4V based biomaterials.

show abstract

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Additively manufactured Ti‐29Nb‐21Zr shows improved oxide polarization resistance versus Ti‐6Al‐4V in inflammatory simulating solution

Kurtz

Wessinger

Mace

et al. 2023

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

show abstract

Deep Neural Network Predicts Ti‐6Al‐4V Dissolution State Using Near‐Field Impedance Spectra

Kurtz,

Yang,

Liu

et al. 2023

Adv Funct Materials

Self Cite

View full text Add to dashboard Cite

Retrieval studies document Ti‐6Al‐4V selective dissolution within crevices of total hip replacement devices. A gap persists in the fundamental understanding of Ti‐6Al‐4V crevice corrosion in vivo and its impact on local impedance. Previous studies use nearfield electrochemical impedance spectroscopy (nEIS) for characterization of retrieved CoCrMo surfaces and phase angle symmetry‐based EIS (sbEIS) for rapid data acquisition. In this study, these methods are combined with a deep neural network to characterize the local impedance changes after selective dissolution. It is hypothesized that structural changes occurring during dissolution will manifest as property changes to the oxide film capacitance. First, after sustained cathodic activation, the Ti‐6Al‐4V β phase selectively dissolves from the surface. Next, nEIS acquires n = 100 control and n = 105 dissolved spectra. Over dissolved regions, oxide capacitance significantly increases (Log10Q = ‐4.17 versus ‐4.78 (Scm−2(s)α), p = 0.000). Using single frequency EIS (5000 Hz), a capacitance‐based scanning impedance microscopy method identifies dissolved regions within seconds. Finally, Bode phase plots of the 205 control and dissolved nEIS spectra are input into a deep neural network. After training with n = 180 spectra, the model predicts the surface state for n = 25 previously unseen nEIS spectra with 96% accuracy.

show abstract

Oxide degradation precedes additively manufactured Ti‐6Al‐4V selective dissolution: An unsupervised machine learning correlation of impedance and dissolution compared to Ti‐29Nb‐21Zr

Kurtz,

Alaniz,

Kurtz

et al. 2023

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

Additively manufactured (AM) Ti‐6Al‐4V devices are implanted with increasing frequency. While registry data report short‐term success, a gap persists in our understanding of long‐term AM Ti‐6Al‐4V corrosion behavior. Retrieval studies document β phase selective dissolution on conventionally manufactured Ti‐6Al‐4V devices. Researchers reproduce this damage in vitro by combining negative potentials (cathodic activation) and inflammatory simulating solutions (H2O2‐phosphate buffered saline). In this study, we investigate the effects of these adverse electrochemical conditions on AM Ti‐6Al‐4V impedance and selective dissolution. We hypothesize that cathodic activation and H2O2 solution will degrade the oxide, promoting corrosion. First, we characterized AM Ti‐6Al‐4V samples before and after a 48 h −0.4 V hold in 0.1 M H2O2/phosphate buffered saline. Next, we acquired nearfield electrochemical impedance spectroscopy (EIS) data. Finally, we captured micrographs and EIS during dissolution. Throughout, we used AM Ti‐29Nb‐21Zr as a comparison. After 48 h, AM Ti‐6Al‐4V selectively dissolved. Ti‐29Nb‐21Zr visually corroded less. Structural changes at the AM Ti‐6Al‐4V oxide interface manifested as property changes to the impedance. After dissolution, the log‐adjusted constant phase element (CPE) parameter, Q, significantly increased from −4.75 to −3.84 (Scm−2(s)α) (p = .000). The CPE exponent, α, significantly decreased from .90 to .84 (p = .000). Next, we documented a systematic decrease in oxide polarization resistance before pit nucleation and growth. Last, using k‐means clustering, we established a structure–property relationship between impedance and the surface's dissolution state. These results suggest that AM Ti‐6Al‐4V may be susceptible to in vivo crevice corrosion within modular taper junctions.

show abstract

Cathodic activation and inflammatory species are critical to simulating in vivo Ti-6Al-4V selective dissolution

Cited by 19 publications

References 42 publications

Additively manufactured Ti‐29Nb‐21Zr shows improved oxide polarization resistance versus Ti‐6Al‐4V in inflammatory simulating solution

Additively manufactured Ti‐29Nb‐21Zr shows improved oxide polarization resistance versus Ti‐6Al‐4V in inflammatory simulating solution

Deep Neural Network Predicts Ti‐6Al‐4V Dissolution State Using Near‐Field Impedance Spectra

Oxide degradation precedes additively manufactured Ti‐6Al‐4V selective dissolution: An unsupervised machine learning correlation of impedance and dissolution compared to Ti‐29Nb‐21Zr

Contact Info

Product

Resources

About