Cathéters en polyuréthane et chimiothérapie antinéoplasique. Etude expérimentale

Surface and mechanical properties of polyurethane central venous catheters after repeated contact with chemotherapy excipient solutions

“…Nevertheless, very few studies have tested polyurethane catheters after contact with chemotherapy drugs in vitro. The few studies that exist have shown that these drugs alter PU catheter inner surfaces and increase the irregularities on the surface 21,22 …”

“…The few studies that exist have shown that these drugs alter PU catheter inner surfaces and increase the irregularities on the surface. 21,22 This article examines the effect of such chemotherapy cycles on the catheters by mimicking the repeated and successive infusions of chemotherapy treatments inside the polyurethane catheters but without the active pharmaceutical ingredients (APIs), using only the excipients. The study focuses on the changes in the catheter's mechanical properties and the surface state's evolution.…”