Catheter simulator software tool to generate electrograms of any multi-polar diagnostic catheter from 3D atrial tissue

Shillieto, Kristina E.; Ganesan, Prasanth; Salmin, Anthony; Cherry, Elizabeth M.; Pertsov, Arkady M.; Ghoraani, Behnaz

doi:10.1109/embc.2016.7591297

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…For each electrode, the electrogram was obtained as a weighted summation of the effects of every single cell considered as a dipole and a sampling frequency of 1 kHz ( Spach et al, 1979 ; Shillieto et al, 2016 ).…”

Section: Methodsmentioning

confidence: 99%

Computational Analysis of Mapping Catheter Geometry and Contact Quality Effects on Rotor Detection in Atrial Fibrillation

et al. 2021

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Atrial fibrillation (AF) is the most common cardiac arrhythmia and catheter mapping has been proved to be an effective approach for detecting AF drivers to be targeted by ablation. Among drivers, the so-called rotors have gained the most attention: their identification and spatial location could help to understand which patient-specific mechanisms are acting, and thus to guide the ablation execution. Since rotor detection by multi-electrode catheters may be influenced by several structural parameters including inter-electrode spacing, catheter coverage, and endocardium-catheter distance, in this study we proposed a tool for testing the ability of different catheter shapes to detect rotors in different conditions. An approach based on the solution of the monodomain equations coupled with a modified Courtemanche ionic atrial model, that considers an electrical remodeling, was applied to simulate spiral wave dynamics on a 2D model for 7.75 s. The developed framework allowed the acquisition of unipolar signals at 2 KHz. Two high-density multipolar catheters were simulated (Advisor™ HD Grid and PentaRay®) and placed in a 2D region in which the simulated spiral wave persists longer. The configuration of the catheters was then modified by changing the number of electrodes, inter-electrodes distance, position, and atrial-wall distance for assessing how they would affect the rotor detection. In contact with the wall and at 1 mm distance from it, all the configurations detected the rotor correctly, irrespective of geometry, coverage, and inter-electrode distance. In the HDGrid-like geometry, the increase of the inter-electrode distance from 3 to 6 mm caused rotor detection failure at 2 mm distance from the LA wall. In the PentaRay-like configuration, regardless of inter-electrode distance, rotor detection failed at 3 mm endocardium-catheter distance. The asymmetry of this catheter resulted in rotation-dependent rotor detection. To conclude, the computational framework we developed is based on realistic catheter shapes designed with parameter configurations which resemble clinical settings. Results showed it is well suited to investigate how mapping catheter geometry and location affect AF driver detection, therefore it is a reliable tool to design and test new mapping catheters.

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Section: Methodsmentioning

confidence: 99%

Computational Analysis of Mapping Catheter Geometry and Contact Quality Effects on Rotor Detection in Atrial Fibrillation

et al. 2021

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“…In the case of the 2D simulations, the electrodes' coordinates were directly placed on the 2D tissue. For the simulations in the real 3D anatomy, we used our method [34] to project and register the plane of principal curvature of the catheter to the 3D surface. The unipolar electrode coordinates were used to acquire the transmembrane potentials from the corresponding location on the atrial tissue.…”

Section: Catheter and Electrogram Simulationsmentioning

confidence: 99%

Atrial fibrillation source area probability mapping using electrogram patterns of multipole catheters

et al. 2020

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Background Catheter ablation therapy involving isolation of pulmonary veins (PVs) from the left atrium is performed to terminate atrial fibrillation (AF). Unfortunately, standalone PV isolation procedure has shown to be a suboptimal success with AF continuation or recurrence. One reason, especially in patients with persistent or high-burden paroxysmal AF, is known to be due to the formation of repeating-pattern AF sources with a meandering core inside the atria. However, there is a need for accurate mapping and localization of these sources during catheter ablation. Methods A novel AF source area probability (ASAP) mapping algorithm was developed and evaluated in 2D and 3D atrial simulated tissues with various arrhythmia scenarios and a retrospective study with three cases of clinical human AF. The ASAP mapping analyzes the electrograms collected from a multipole diagnostic catheter that is commonly used during catheter ablation procedure to intelligently sample the atria and delineate the trajectory path of a meandering repeating-pattern AF source. ASAP starts by placing the diagnostic catheter at an arbitrary location in the atria. It analyzes the recorded bipolar electrograms to build an ASAP map over the atrium anatomy and suggests an optimal location for the subsequent catheter location. ASAP then determines from the constructed ASAP map if an AF source has been delineated. If so, the catheter navigation is stopped and the algorithm provides the area of the AF source. Otherwise, the catheter is navigated to the suggested location, and the process is continued until an AF-source area is delineated. Results ASAP delineated the AF source in over 95% of the simulated human AF cases within less than eight catheter placements regardless of the initial catheter placement. The success of ASAP in the clinical AF was confirmed by the ablation outcomes and the electrogram patterns at the delineated area. Conclusion Our analysis indicates the potential of the ASAP mapping to provide accurate information about the area of the meandering repeating-pattern AF sources as AF ablation targets for effective AF termination. Our algorithm could improve the success of AF catheter ablation therapy by locating and subsequently targeting patient-specific and repeating-pattern AF sources inside the atria.

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“…It is also urgent to develop human circulation model simulators that do not need animal from the bioethical viewpoint. Recently, studies on virtual reality simulation have been reported [8][9][10], but it cannot reproduce the catheter insertion feeling or the sense of insertion length. Past studies on simulators have reported vascular models simulating the coronary artery, arteriovenous circulation in the arm, or a coronary circulation simulator for children [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Construction of arteriovenous circulation system to gain of the close feeling to insert a catheter into human vessel

et al. 2018

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We first developed a model of the normal human left heart and simulated blood and clarified the relationship between catheter insertion load and temperature in the coronary artery. The close feeling to insert a catheter into human vessels could be reproduced for medical staff. We also developed an arteriovenous circulation simulator (AVCS), simulating the normal heart and blood vessels, reproduced hemodynamics and simulated angiography and catheterization procedures. Using an auxiliary artificial heart, simulated blood was circulated through AVCS and blood pressure was set to 120/72 mmHg of peripheral vascular resistance by a pressure gradient regulator. Because the increase in contrast agent volume in the circulation fluid of AVCS affects X-ray fluoroscopy, we also developed methods for neutralization and removal of ionic contrast agents. The developed AVCS enabled to simulate following procedures: Guiding catheterization; directional coronary atherectomy (DCA); balloon catheterization; and stent delivery system introduction.

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Catheter simulator software tool to generate electrograms of any multi-polar diagnostic catheter from 3D atrial tissue

Cited by 4 publications

References 7 publications

Computational Analysis of Mapping Catheter Geometry and Contact Quality Effects on Rotor Detection in Atrial Fibrillation

Computational Analysis of Mapping Catheter Geometry and Contact Quality Effects on Rotor Detection in Atrial Fibrillation

Atrial fibrillation source area probability mapping using electrogram patterns of multipole catheters

Construction of arteriovenous circulation system to gain of the close feeling to insert a catheter into human vessel

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