Catheter-Related Infections Caused by the Mycobacterium fortuitum Complex: 15 Cases and Review

Raad, Issam; Vartivarian, Shahe; Khan, Azim; Bodey, Gerald P.

doi:10.1093/clinids/13.6.1120

Cited by 143 publications

(84 citation statements)

References 31 publications

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“…Members of this group, especially the three major species Mycobacterium fortuitum, Mycobacterium chelonae and Mycobacterium abscessus, have been reported as aetiological agents of a variety of infections, including bacteraemia and disseminated disease in patients with long-term venous catheters (Raad et al, 1991). They have also been involved in nosocomial outbreaks or pseudooutbreaks related to contamination of hospital water supplies and reagents (Ashford et al, 1997;Chadha et al, 1998;LaBombardi et al, 2002).…”

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confidence: 99%

Mycobacterium canariasense sp. nov.

Jiménez

Campos-Herrero

García

et al. 2004

International Journal of Systematic and Evolutionary Microbiology

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A novel rapidly growing, non-pigmented mycobacterium was isolated from blood samples obtained from 17 patients with febrile syndrome. Bacterial growth occurred at 30 and 37 6C on Lö wenstein-Jensen medium and also on MacConkey agar without crystal violet. Strains contained a-and a9-mycolates in their cell wall. Sequence analysis of the hsp65 and 16S rRNA genes identified the isolates as rapidly growing mycobacteria. Sequences of both genes were unique within the mycobacteria. DNA-DNA hybridization showed that the isolates had less than 15 % reassociation with 13 other recognized rapidly growing mycobacteria. The name Mycobacterium canariasense sp. nov. is proposed for this novel opportunistic pathogen, which is most closely related to Mycobacterium diernhoferi. The type strain is 502329 T (=CIP 107998 T =CCUG 47953 T ).

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mentioning

confidence: 99%

Mycobacterium canariasense sp. nov.

Jiménez

Campos-Herrero

García

et al. 2004

International Journal of Systematic and Evolutionary Microbiology

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“…Rapidly growing mycobacteria are not usually pathogenic for humans but they can cause several type of infections including skin and soft tissue infections, osteomyelitis, lymphadenitis, disseminated disease, meningitis, postsurgical wound infections, infections of prostethic devices, and chronic lung disease (3)(4)(5)(6)(7)(15)(16)(17)(18). Some cases have been described in Colombia (8,11).…”

Section: Discussionmentioning

confidence: 99%

“…In clinical conditions, rapidly growing mycobacteria have been related to skin and soft tissue infections (frequently postsurgical wound infections), pulmonary disease, and colonization of implanted materials such as prosthetics, catheters and sutures; these infections could result in sepsis and disseminated disease (3)(4)(5)(6)(7). Clinical cases of environmental opportunistic mycobacteria, including rapidly growing mycobacteria, have been reported in Colombia (8)(9)(10)(11).…”

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confidence: 99%

Micobacteriosis diseminada con compromiso de válvula aórtica protésica: primer caso de Mycobacterium peregrinum de tipo III reportada en Colombia

Torres‐Duque¹,

Diaz²,

Vargas³

et al. 2011

biomedica

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Rapidly growing mycobacteria are non-tuberculous mycobacteria amply present in the environment. Although they are not usually pathogenic for humans, they are opportunistic in that they can cause disease in people with disadvantageous conditions or who are immunocompromised. Mycobacterium peregrinum, an opportunistic, rapidly growing mycobacteria, belongs to the M. fortuitum group and has been reported as responsible for human cases of mycobacteriosis. A case of M. peregrinum type III is herein reported as the first in Colombia. It presented as a disseminated disease involving a prosthetic aortic valve (endocarditis) in a seventeen-year-old girl with a well-established diagnosis of prosthetic aortic valve endocarditis who was referred for a surgical replacement. Due to a congenital heart disease (subaortic stenosis with valve insufficiency), she had two previous aortic valve implantation surgeries. One year after the second implantation, the patient presented with respiratory symptoms and weight lost indicative of lung tuberculosis. A chest X-ray did not show parenchymal compromise but several Ziehl-Neelsen stains were positive. An echocardiography showed a vegetation on the prosthetic aortic valve. In blood and sputum samples, M. peregrinum type III was identified through culture, biochemical tests and hsp65 gene molecular analysis (PRA). The patient underwent a valve replacement and received a multidrug antimycobacterial treatment. Progressive recovery ensued and further samples from respiratory tract and blood were negative for mycobacteria.Key words: Mycobacterium, Mycobacterium peregrinum infections, aortic valve, endocarditis, Colombia. Micobacteriosis diseminada con compromiso de válvula aórtica protésica: primer caso de Mycobacterium peregrinum de tipo III reportada en ColombiaLas micobacterias de rápido crecimiento son microorganismos pertenecientes a las micobacterias no tuberculosas que tienen amplia distribución ambiental. Aunque usualmente no son patógenas para los humanos, en condiciones desfavorables, pueden causar enfermedad en la población general o en huéspedes inmunocomprometidos, por lo cual se consideran oportunistas. Mycobacterium preregrinum es una micobacteria de rápido crecimiento perteneciente al complejo fortuitum que ha sido reportado como responsable de casos de micobacteriosis en humanos. Se presenta el caso de una micobacteriosis por M. peregrinum de tipo III, el primero reportado en Colombia, en una paciente de 17 años de edad con una endocarditis de una válvula aórtica protésica, implantada inicialmente por estenosis subaórtica congénita con insuficiencia y, posteriormente, por estenosis aórtica relacionada con la válvula inicialmente implantada. Un año después del segundo implante, presentó sintomas respiratorios y pérdida de peso sugestivos de tuberculosis pulmonar. Las coloraciones de Ziehl-Neelsen del esputo fueron positivas aunque la radiografía de tórax no mostró compromiso del parénquima. En el ecocardiograma se encontró una vegetación en la válvula aórtica. En las muestras...

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“…6 However, M. fortuitum can infect almost every tissue and organ system. It has been implicated in skin and soft tissue infections, trauma site and catheterrelated infections, 7 keratitis, 8 peritonitis, artificial heart valve replacement infections, augmentation mammoplasty, cardiothoracic surgery, and arthroplasty. 9 In general, M. fortuitum usually causes localized infections with low mortality in immunocompetent patients.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium fortuitum–induced persistent parotitis: Successful therapy with clarithromycin and ciprofloxacin

Chen

et al. 2007

Head & Neck

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Background. Parotitis caused by nontuberculous mycobacteria, a very rare disease entity, has never been reported to be caused by Mycobacterium fortuitum (M. fortuitum) in the literature.Methods and Results. An 8-year-old girl was seen with painful swelling of the right parotid gland despite antibiotic treatment of more than 1 month. Elevated serum amylase activity and diffuse contrast-enhanced CT of the parotid gland confirmed the diagnosis of parotitis. Histopathological study of specimens taken from the right parotid tail mass showed granulomatous inflammation with acid-fast positive bacilli; culture later confirmed M. fortuitum. After administration of clarithromycin and ciprofloxacin for 9 consecutive months, the parotitis and parotid tail mass were completely resolved at follow-up examination.Conclusion. To our knowledge, this is the first case report of parotitis caused by M. fortuitum and its successful medical treatment. V

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Catheter-Related Infections Caused by the Mycobacterium fortuitum Complex: 15 Cases and Review

Cited by 143 publications

References 31 publications

Mycobacterium canariasense sp. nov.

Mycobacterium canariasense sp. nov.

Micobacteriosis diseminada con compromiso de válvula aórtica protésica: primer caso de Mycobacterium peregrinum de tipo III reportada en Colombia

Mycobacterium fortuitum–induced persistent parotitis: Successful therapy with clarithromycin and ciprofloxacin

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