Catheter-related bloodstream infection with removal of catheter in pediatric oncology patients: a 10-year experience in Taiwan

Abstract

Factors such as microbiological isolates, age of infection, the status of malignancy, and neutropenia are related to catheter outcome. The reduction in patients with positive cultures needing removal of the catheters can be related to improved nursing care and more aggressive antibiotic therapy.

Central Line–Associated Bloodstream Infections in Children With Hematologic and Oncologic Diseases: First Prevalence Results From a University Hospital

“…However, neutropenia was an important factor for catheter removal (Celebi et al, 2013), Neutropenia may be correlated with clinical severity of CLABSI. In the study by Chen, Yang, Jaing, Lai, and Hung (2012) CLABSI occurred especially during severe neutropenia. Our result is consistent with those of other studies that emphasize the significance of neutropenia following receipt of chemotherapy in patients with hematologic malignancies as a major risk factor for infection.…”

“…The National Nosocomial Infections Surveillance System Pre-Report indicated that the rate of CLABSI was 6.0 per 1,000 catheter-days in pediatric intensive care units, but no data were available for the PHO unit (Ertek, Muezzinoglu, Kurtoglu, Arabacı, & Cetinkaya Sardan, 2010). CLABSI rates changed from 0 to 7.4 per 1,000 catheter-days in the PHO population (Abedin & Kapoor, 2008; Allen et al, 2008; Biwersi et al, 2009; Celebi et al, 2013; Chenet al, 2012; Fadoo et al, 2015; Hatakeyama et al, 2011; Langley et al, 2015; Matsuzaki et al, 2006; Newman et al, 2012; Pinon et al, 2009; Shen, Gao, Wang, Mao, & Wang, 2009; Simon et al, 2008; Tsai et al, 2015; Yazıcı et al, 2013; Zachariah et al, 2014). It is important to keep in mind that this is a sample of patients with hematological conditions.…”

“…Recommendations from CDC and Hospital Infection Control Practices Advisory Committee, the clinical practice guidelines of the Infectious Diseases Society of America, and the German Society of Pediatric Oncology and Hematology recommendations were used to identify CLABSI in patients with a CVC (Hentrich et al, 2014; Mermel et al, 2009; O’Grady et al, 2002, 2011). However, the CLABSI rate is not clear for children with hematologic and oncologic diseases in some studies in the literature, and the definitions have been highly variable for CLABSI (Abedin & Kapoor, 2008; Biwersi et al, 2009; Chen et al, 2012; Hatakeyama et al, 2011; Matsuzaki et al, 2006; Shen et al, 2009; Zachariah et al, 2014). There is a key difference between the CDC/NHSN Protocol Clarifications CLABSI criteria regarding what might be regarded as a possible contaminant.…”

Catheter‐related blood stream infection caused by Mycobacterium chelonae in a child with myeloid leukemia associated with Down syndrome

“…In hospitals, RGM may also be responsible for outbreaks of infections that originate from contaminated medical equipment and water 3 . However, RGM are considered a rare cause of CRBSIs 4‐6 . Herein, we report a patient of a myeloid leukemia associated with Down syndrome (ML‐DS) who developed a CRBSI caused by Mycobacterium chelonae .…”

Infantile Crohn's disease is one of the risk factors for catheter‐related bloodstream infection

“…reported that leukemia was an independent risk factor for CR‐BSI . The overall incidence density of CR‐BSI in pediatric malignancy was reported as 0.44 per 1000 catheter days, but there is a gap in the CR‐BSI rate between malignant disease and intestinal failure: there are no studies on the risk of CR‐BSI in pediatric patients with malignant disease and intestinal disorder at a single center …”