Catheter-related bacteremia by Cupriavidus metallidurans

D’Inzeo, Tiziana; Santangelo, Rosaria; Fiori, Barbara; Angelis, Giulia De; Conte, Viola; Giaquinto, Alessia; Palucci, Ivana; Scoppettuolo, Giancarlo; Florio, Viviana Di; Giani, Tommaso; Sanguinetti, Maurizio; Rossolini, Gian María; Spanu, Teresa

doi:10.1016/j.diagmicrobio.2014.09.015

Cited by 16 publications

(20 citation statements)

References 29 publications

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“…Cupriavidus metallidurans strains are, next to metal-contaminated soils (Diels and Mergeay, 1990 ; Brim et al, 1999 ; Goris et al, 2001 ), being increasingly recovered from other anthropogenic environments not typified by metal contamination (Van Houdt et al, 2012 ; Mijnendonckx et al, 2013 ), including medically-relevant sources (Coenye et al, 2005 ; Langevin et al, 2011 ; D'Inzeo et al, 2015 ). They are studied for their resistance and adaptation to toxic levels of metal ions.…”

Section: Introductionmentioning

confidence: 99%

Zinc-Induced Transposition of Insertion Sequence Elements Contributes to Increased Adaptability of Cupriavidus metallidurans

et al. 2016

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Bacteria can respond to adverse environments by increasing their genomic variability and subsequently facilitating adaptive evolution. To demonstrate this, the contribution of Insertion Sequence (IS) elements to the genetic adaptation of Cupriavidus metallidurans AE126 to toxic zinc concentrations was determined. This derivative of type strain CH34, devoid of its main zinc resistance determinant, is still able to increase its zinc resistance level. Specifically, upon plating on medium supplemented with a toxic zinc concentration, resistant variants arose in which a compromised cnrYX regulatory locus caused derepression of CnrH sigma factor activity and concomitant induction of the corresponding RND-driven cnrCBA efflux system. Late-occurring zinc resistant variants likely arose in response to the selective conditions, as they were enriched in cnrYX disruptions caused by specific IS elements whose transposase expression was found to be zinc-responsive. Interestingly, deletion of cnrH, and consequently the CnrH-dependent adaptation potential, still enabled adaptation by transposition of IS elements (ISRme5 and IS1086) that provided outward-directed promoters driving cnrCBAT transcription. Finally, adaptation to zinc by IS reshuffling can also enhance the adaptation to subsequent environmental challenges. Thus, transposition of IS elements can be induced by stress conditions and play a multifaceted, pivotal role in the adaptation to these and subsequent stress conditions.

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Section: Introductionmentioning

confidence: 99%

Zinc-Induced Transposition of Insertion Sequence Elements Contributes to Increased Adaptability of Cupriavidus metallidurans

et al. 2016

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“…Patients infected with Cupriavidus species are usually immunocompromised [2,3,5,7]. Cases of infection with this genus have also been reported in elderly patients without obvious immunodeficiency [15,16].…”

Section: Discussionmentioning

confidence: 99%

“…Cupriavidus is a genus of aerobic gram-negative glucose-nonfermenting bacillus common in the environment but rarely isolated from clinical specimens. Clinical manifestations of infection with Cupriavidus species are varied and include pneumonia, bacteremia, meningitis, and septicemia in children [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Cellulitis Caused by a Novel Cupriavidus Species Strain J1218 Identified by Whole Genome Sequencing

Yoon

Lim

et al. 2019

Ann Clin Microbiol

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We report a case of cellulitis caused by a novel Cupriavidus species identified using whole-genome sequence analysis. Subcutaneous tissue biopsies from the left lower leg of a 67-year-old man who suffered from cellulitis were cultured. Round, convex, gray and non-hemolytic colonies were recovered after 72-h incubation. 16S rRNA sequence analysis showed 98.6% similarity with Cupriavidus basilensis DSM 11853(T) in the NCBI database and 99.9% similarity with C. basilensis KF708 in the EzBioCloud database. Genomic analysis using the MiSeq platform (Illumina, USA) and the TrueBac ID database (ChunLab, Korea) revealed that the average nucleotide identity (ANI) of this strain with C. basilensis DSM 11853(T) was 87.6%. The patient was treated with oral cefditoren pivoxil for 9 weeks. This study is the first to report cellulitis caused by Cupriavidus species strain J1218. (Ann Clin Microbiol 2019;22:105 -109)

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“…1 Widely distributed in nature, specially in water and soil, isolation has occurred in environmental samples of pool water, groundwater, tap and bottled mineral water when suspected to be a potential source of contamination in the clinical setting. [2][3][4][5][6][7][8] The genus Cupriavidus contains 13 species, being C. pauculus historically implicated in the majority of the, nevertheless rare, infections. Both immunocompromised patients (with underlying comorbidities such as Chronic Kidney Disease (CKD), hematologic malignancies and Acquired Immunodeficiency Syndrome) and immunocompetent patients have been reported with infection, either in community or nosocomial setting.…”

Section: Introductionmentioning

confidence: 99%

Cupriavius pauculus causing a respiratory tract infection in a post-kidney-transplant patient: A firstly described rare clinical case

Fiel¹,

Calça²,

Cacheira³

et al. 2020

PPIJ

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Catheter-related bacteremia by Cupriavidus metallidurans

Cited by 16 publications

References 29 publications

Zinc-Induced Transposition of Insertion Sequence Elements Contributes to Increased Adaptability of Cupriavidus metallidurans

Zinc-Induced Transposition of Insertion Sequence Elements Contributes to Increased Adaptability of Cupriavidus metallidurans

Cellulitis Caused by a Novel Cupriavidus Species Strain J1218 Identified by Whole Genome Sequencing

Cupriavius pauculus causing a respiratory tract infection in a post-kidney-transplant patient: A firstly described rare clinical case

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