Catheter management in neonates with bloodstream infection and a percutaneously inserted central venous catheter in situ: Removal or not?

Tsai, Ming-Horng; Hsu, Jen‐Fu; Lien, Reyin; Huang, Hsuan-Rong; Chiang, Chiao-Ching; Chu, Shih-Ming; Liang, Hwey-Fang; Huang, Yhu‐Chering

doi:10.1016/j.ajic.2011.04.051

Cited by 21 publications

(12 citation statements)

References 29 publications

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“…These results were concordant with the data of other publications. [13][14][15][16][17] This was in contrast, to the data reported in the NHSN report in which the CRBSI ranged from 3.1-6.4 per 1,000 CVC days. 18 This high rate could be related to increased number of VLBW of our studied group who needed frequent handling and mechanical ventilation.…”

Section: Discussioncontrasting

confidence: 55%

“…37 Moreover, TPN need prolongs the duration of CVC stay. 13 Shouman et al found that the use of full dose intralipids in TPN decreases the rate of blood stream infection clearance compared to restricted dose of intralipids to 1 g/kg/d. Furthermore, TPN adversely affects phagocytosis in neutrophils and increases epithelial permeability.…”

Section: Subhani Et Al Postulated That a Higher Infection Ratementioning

confidence: 99%

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Central venous catheter-related blood stream infections in neonatal care unit

Badr

Hammad

Salama

et al. 2013

Int. j. infect. control

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The aim of this study was to detect the rate of catheter-related bloodstream infection (CRBSI) in NICU of Mansoura University Children's Hospital and to focus on possible predictors of infection. A cross sectional comparative study was performed to detect the rate of CRBSI among neonates with central vascular catheters during the period between January 2009 and April 2012. Then, a nested case control study done among CRBSI cases and central vascular catheters none infected as a control group to detect predictors associated with their occurrence. Blood samples were collected from 111 neonates clinically suspected of septicemia and had inserted venous line. Central, peripheral blood and catheter tip cultures were done for each case.CRBSI was confirmed in 69 cases as central blood culture count was more than 3 folds of peripheral blood culture count. Catheter tip culture showed more than 103 CFU/ ml per catheter of the same organisms. Low birth weight, age below 7 days, prematurity, mechanical ventilation, TPN administration and prolonged catheter stay were predictors of CRBSI. Logistic regression of the studied predictors showed that birth weight, TPN administration and length of central venous catheter stay were significant predictors of CRBSI. CRBSI is a common problem in NICU. Predictors of CRBSI included low birth weight, prematurity and mechanical ventilation. Potential use of TPN, prolonged catheter stay and low birth weight are independent predictors for CRBSI.

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Section: Discussioncontrasting

confidence: 55%

Section: Subhani Et Al Postulated That a Higher Infection Ratementioning

confidence: 99%

Central venous catheter-related blood stream infections in neonatal care unit

Badr

Hammad

Salama

et al. 2013

Int. j. infect. control

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“…13,18 By contrast, about 70e90% of PICC-associated CLA-BSIs were caused by coagulase-negative staphylococci (CoNS). 11e13, 19 Previous researchers considered that intraluminal colonization and increased frequency of hub manipulation might be the main pathogenesis of CLABSIs. 12,20 However, these studies had controversial findings to make a definite explanation, and their conclusion could not be applied completely to CLA-BSI in patients with PICCs.…”

Section: Introductionmentioning

confidence: 99%

Increased frequency of peripheral venipunctures raises the risk of central-line associated bloodstream infection in neonates with peripherally inserted central venous catheters

Cheng

Huang

et al. 2016

Journal of Microbiology, Immunology and Infection

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“…Some retrospective cohort studies have indicated that bloodstream infections progress to persistent bacteraemia or fungaemia with end-organ damage if the CVC is not removed promptly (Eppes 1989;Karlowicz 2000;Benjamin 2001;Nazemi 2003;Tsai 2012). However, these studies have inherent methodological weaknesses with potential for bias and should be interpreted with caution since their findings may be due to confounding factors such as clinicians electing to delay CVC removal in smaller, less mature or sicker infants.…”

Section: Discussionmentioning

confidence: 94%