Catheter impregnation, coating or bonding for reducing central venous catheter-related infections in adults

Lai, Nai Ming; Chaiyakunapruk, Nathorn; Lai, Nai An; O'Riordan, Elizabeth; Pau, Wilson Shu Cheng; Saint, Sanjay

doi:10.1002/14651858.cd007878.pub3

Cited by 86 publications

(35 citation statements)

References 147 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Used appropriately, biocides offer an important means of reducing the transmission and growth of microorganisms (34)(35)(36). They have the potential, through disinfection and antisepsis, to reduce the incidence of infections and the burden on antibiotics (35,37) and to protect consumers through the preservation of liquid formulations (38).…”

Section: Discussionmentioning

confidence: 99%

Loss of Function in Escherichia coli Exposed to Environmentally Relevant Concentrations of Benzalkonium Chloride

Forbes

Morgan

Humphreys

et al. 2019

Appl Environ Microbiol

View full text Add to dashboard Cite

Assessing the risk of resistance associated with biocide exposure commonly involves exposing microorganisms to biocides at concentrations close to the MIC. With the aim of representing exposure to environmental biocide residues, Escherichia coli MG1655 was grown for 20 passages in the presence or absence of benzalkonium chloride (BAC) at 100 ng/liter and 1,000 ng/liter (0.0002% and 0.002% of the MIC, respectively). BAC susceptibility, planktonic growth rates, motility, and biofilm formation were assessed, and differentially expressed genes were determined via transcriptome sequencing. Planktonic growth rate and biofilm formation were significantly reduced (P < 0.001) following BAC adaptation, while BAC minimum bactericidal concentration increased 2-fold. Transcriptomic analysis identified 289 upregulated and 391 downregulated genes after long-term BAC adaptation compared with the respective control organism passaged in BAC-free medium. When the BAC-adapted bacterium was grown in BAC-free medium, 1,052 genes were upregulated and 753 were downregulated. Repeated passage solely in biocide-free medium resulted in 460 upregulated and 476 downregulated genes compared with unexposed bacteria. Long-term exposure to environmentally relevant BAC concentrations increased the expression of genes associated with efflux and reduced the expression of genes associated with outer-membrane porins, motility, and chemotaxis. This was manifested phenotypically through the loss of function (motility). Repeated passage in a BAC-free environment resulted in the upregulation of multiple respiration-associated genes, which was reflected by increased growth rate. In summary, repeated exposure of E. coli to BAC residues resulted in significant alterations in global gene expression that were associated with minor decreases in biocide susceptibility, reductions in growth rate and biofilm formation, and loss of motility. IMPORTANCE Exposure to very low concentrations of biocides in the environment is a poorly understood risk factor for antimicrobial resistance. Repeated exposure to trace levels of the biocide benzalkonium chloride (BAC) resulted in loss of function (motility) and a general reduction in bacterial fitness but relatively minor decreases in susceptibility. These changes were accompanied by widespread changes in the Escherichia coli transcriptome. These results demonstrate the importance of including phenotypic characterization in studies designed to assess the risks of biocide exposure.

show abstract

Section: Discussionmentioning

confidence: 99%

Loss of Function in Escherichia coli Exposed to Environmentally Relevant Concentrations of Benzalkonium Chloride

Forbes

Morgan

Humphreys

et al. 2019

Appl Environ Microbiol

View full text Add to dashboard Cite

show abstract

“…A recent meta-analysis demonstrated a 2% absolute risk reduction and relative risk of 0.62 [22, 23]. The benefits of using impregnated catheters varies according to clinical setting, with the most significant benefits being realized in settings that are higher risk for CLABSI (e.g.…”

Section: Closed Icu Vs Open Icumentioning

confidence: 99%

Prevention of Central Line–Associated Bloodstream Infections

Bell

O’Grady

2017

Infectious Disease Clinics of North America

167

102

View full text Add to dashboard Cite

Central venous catheters (CVC) are commonly used in critically ill patients and offer several advantages to peripheral intravenous access. However, indwelling CVCs have the potential to lead to blood stream infections, with the risk increasing with an array of characteristics such as catheter choice, catheter location, insertion technique and catheter maintenance. Evidence-based guidelines have led to a significant reduction in the incidence of blood stream infections associated with CVCs. The combination of guideline implementation combined with newer technologies has the potential to further reduce morbidity and mortality from infections related to CVCs.

show abstract

“…In addition, our policy of using ciprofloxacin-impregnated contrast material during ERCP for the last 5 years has been proved effective. Local injection of antibiotics along with the non-sterile contrast material during biliary opacification is based on the rationale of lock therapy, as used for the sterilization of central iv catheters [12], and has been particularly useful in manipulation of the biliary tree during ERCP in our practice up to now. Future studies investigating the local use of antibiotics in this patient population are warranted.…”

Section: Discussionmentioning

confidence: 99%

A fully covered self-expandable metal stent anchored by a 10-Fr double pigtail plastic stent: an effective anti-migration technique

Katsinelos¹,

Lazaraki²,

Gkagkalis³

et al. 2016

aog

View full text Add to dashboard Cite

BackgroundFully covered self-expandable metal stents (FCSEMS) have been used successfully in the treatment of malignant and benign biliary strictures. However, stent migration is a major complication. We investigated the efficacy of anchoring FCSEMS with a 10-Fr double-pigtail plastic stent to prevent migration in patients with biliary strictures.MethodsBetween January 2012 and May 2013, 10 patients with malignant biliary strictures and one patient with a suprapapillary benign biliary stenosis were enrolled in the study. The primary endpoint of the study was to record the migration rate of FCSEMS.ResultsThe placement of FCSEMSs and the anchoring with a 10-Fr double-pigtail plastic stent were successful in all patients. During a median follow-up period of eight months, proximal or distal migration of FCSEMS was not observed. No procedural complications related to the placement of FCSEMS and/or the anchoring plastic stent were recorded.ConclusionsThe placement of an anchoring 10-Fr double-pigtail stent is a simple and effective anti-migration technique for FCSEMS in patients with malignant biliary strictures.

show abstract

Catheter impregnation, coating or bonding for reducing central venous catheter-related infections in adults

Abstract: Catheter impregnation, coating or bonding for reducing central venous catheter-related infections in adults.

Cited by 86 publications

References 147 publications

Loss of Function in Escherichia coli Exposed to Environmentally Relevant Concentrations of Benzalkonium Chloride

Loss of Function in Escherichia coli Exposed to Environmentally Relevant Concentrations of Benzalkonium Chloride

Prevention of Central Line–Associated Bloodstream Infections

A fully covered self-expandable metal stent anchored by a 10-Fr double pigtail plastic stent: an effective anti-migration technique

Contact Info

Product

Resources

About