Catheter-directed thrombolysis vs. anticoagulant therapy alone in deep vein thrombosis: results of an open randomized, controlled trial reporting on short-term patency

Abstract

(RR) of 28.2% (95% CI: 9.7%-46.7%; P = 0.004). Venous obstruction was found in 10 (20.0%) in the CDT group vs. 26 (49.1%) controls; absolute RR 29.1% (95% CI: 20.0%-38.0%; P = 0.004). Femoral venous insufficiency did not differ between the two groups. Conclusions: After 6 months, additional CDT increased iliofemoral patency from 36% to 64%. The ongoing long-term follow-up of this study will document whether patency is related to improved functional outcome.

US-accelerated catheter-directed thrombolysis for the treatment of deep venous thrombosis

“…The primary patency rates at 6 and 12 months for all of the patients in this registry were 65% and 60%, respectively. The six-month patency rate is similar to those reported for standard CDT combined with anticoagulation in two randomized controlled trials by Elsharawy and Elzayat (31) and Enden et al (32). The degree of thrombolysis was a significant predictor of early and continued patency.…”

Endovascular treatment of acute and subacute iliofemoral deep venous thrombosis using manual aspiration thrombectomy: long-term result of 139 patients from a single center

“…The incidence of symptomatic PE and fatal PE during CDT was 1% and 0% to 0.2%, respectively (12,19). PMT alone had a higher rate of PE complications when used for hemodialysis graft declotting but not when used for DVT treatment (20).…”

Catheter-directed thrombolysis in the treatment of acute deep venous thrombosis: a meta-analysis

“…A growing number of studies have shown the advantages of direct catheter thrombolysis. Enden et al (2009) performed an RCT and showed that CDT combined with anticoagulant therapy significantly improved the rate of iliac and femoral vein patency over anticoagulant therapy alone. The number of published RCTs of CDT increased as European and American experts on the treatment of DVT rigorously evaluated the efficacy of CDT, and meta-analyses and systematic reviews of this topic have also been published (Janssen et al, 2005;Alesh et al, 2007;Vedantham, 2010).…”