Catheter-associated bloodstream infections in adults with cancer: a prospective randomized controlled trial

Mollee, Peter; Okano, Satomi; Abro, Emad Uddin; Looke, David; Kennedy, Glenn; Harper, John; Clouston, John; Kuilenburg, Rosita Van; Geary, Alanna; Joubert, Warren; Eastgate, Melissa; Jones, Mark

doi:10.1016/j.jhin.2020.07.021

Cited by 14 publications

(16 citation statements)

References 15 publications

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“…Previously, [2] we demonstrated that patients with tunnelled lines had a higher risk of infection than did patients with PICC lines (HR 2.05, 95% CI: 1.45-2.91). However, when considered in terms of the timing of infection, this difference is predominantly due to an increased risk of early infections with tunnelled lines as there is little difference between PICC lines and tunnelled lines for late infections (Figure 2).…”

Section: Participantsmentioning

confidence: 77%

“…Detailed methods used for the trial are reported elsewhere [2]. In summary, this randomized trial recruited inpatients and outpatients aged > 14 years with cancer from two tertiary hospitals.…”

Section: Methodsmentioning

confidence: 99%

“…There were only 16 events for the stricter CR-BSI outcome observed hence further analysis of these data was not undertaken. The organisms cultured from episodes of CA-BSI and CR-BSI are reported in Table II of the main RCT publication [2].…”

Section: Participantsmentioning

confidence: 99%

“…It was thought it may relate to the handedness of patients being predominantly right, and right-sided insertions in these patients leading to increased movement and possibly greater bacterial contamination of the catheterized arm. This hypothesis was subsequently tested in a clinical trial of 640 CVADs randomized to catheter insertion into the dominant or non-dominant arm [2].…”

Section: Introductionmentioning

confidence: 99%

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Catheter-associated bloodstream infection in patients with cancer: comparison of left- and right-sided insertions

Jones

Okano

Looke

et al. 2021

Journal of Hospital Infection

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Section: Participantsmentioning

confidence: 77%

Section: Methodsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Catheter-associated bloodstream infection in patients with cancer: comparison of left- and right-sided insertions

Jones

Okano

Looke

et al. 2021

Journal of Hospital Infection

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“…In patients with hematological disorders, PICCs are considered safer than CVCs in terms of the risk of catheter-related complications 4 – 7 . However, thrombosis and bloodstream infection (BSI) are major risks of PICCs, and patients with hematological disorders undergoing chemotherapy are generally considered at higher risk of these complications 8 – 11 . Studies also demonstrated in a cohort of patients including those with non-hematological disorders that a prolonged PICC dwell time and multiple insertions are risk factors of BSI 12 , 13 .…”

Section: Introductionmentioning

confidence: 99%

Catheter-related bloodstream infection associated with multiple insertions of the peripherally inserted central catheter in patients with hematological disorders

Hashimoto

Hosoda

Omura

et al. 2021

Sci Rep

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Patients with hematological disorders are treated with multiple cycles of chemotherapy. As a result, they often require multiple insertions of the peripherally inserted central catheter (PICC) for prolonged periods of time. Although PICCs have been widely used worldwide in various patients, the safety and feasibility of the multiple insertions of the PICC in this population have not been fully verified. We performed a retrospective analysis to clarify the relationship between complications and multiple PICC insertions in patients with hematological disorders who were treated with either chemotherapy or immunotherapy. A total of 651 PICCs were inserted in 261 patients with a median age of 66 years. Acute myeloid leukemia (AML) and non-Hodgkin's lymphoma were the most common diseases in our patient cohort. The total catheter days (CDs) was 29,485 days, with a median catheter duration of 30 days. The rate of catheter-related bloodstream infection (CRBSI) in our patient cohort at high rate of re-insertion was 2.0/1000 CDs. Although multiple PICC insertions were not a risk factor of CRBSI, our findings suggest that a prolonged catheter dwell time may be associated with CRBSI. AML was an important risk factor of CRBSI. While the PICC dwell time depends on the treatment cycle, our findings indicate that it should be limited to approximately 30 days and catheters may be removed and re-inserted as needed.

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Peripherally inserted central venous catheters decrease central line-associated bloodstream infections and change microbiological epidemiology in adult hematology unit: a propensity score-adjusted analysis

et al. 2022

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Catheter-associated bloodstream infections in adults with cancer: a prospective randomized controlled trial

Cited by 14 publications

References 15 publications

Catheter-associated bloodstream infection in patients with cancer: comparison of left- and right-sided insertions

Catheter-associated bloodstream infection in patients with cancer: comparison of left- and right-sided insertions

Catheter-related bloodstream infection associated with multiple insertions of the peripherally inserted central catheter in patients with hematological disorders

Peripherally inserted central venous catheters decrease central line-associated bloodstream infections and change microbiological epidemiology in adult hematology unit: a propensity score-adjusted analysis

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