Abstract:Restoration and maintenance of sinus rhythm by catheter ablation without the use of drugs in patients with congestive heart failure and atrial fibrillation significantly improve cardiac function, symptoms, exercise capacity, and quality of life.
“…During the past few decades, several invasive and noninvasive hemodynamic studies have shed light on the role played by atrial systole and normal sinus rhythm in maintaining adequate cardiac output, particularly during exercise and in patients with heart failure 5, 8, 17, 20, 21, 22, 23. Inadequate cardiac output during AF has been attributed to several mechanisms, including loss of atrial systole, irregular ventricular rhythm with beat‐to‐beat variability, and impaired ventricular filling time 9, 17, 21, 22.…”
BackgroundAtrial fibrillation (AF) has been objectively associated with exercise intolerance in patients with heart failure with reduced ejection fraction; however, its impact in patients with heart failure with preserved ejection fraction has not been fully scrutinized.Methods and ResultsWe identified 1744 patients with heart failure and ejection fraction ≥50% referred for cardiopulmonary stress testing at the Cleveland Clinic (Cleveland, OH), 239 of whom had AF. We used inverse probability of treatment weighting to balance clinical characteristics between patients with and without AF. A weighted linear regression model, adjusted for unbalanced variables (age, sex, diagnosis, hypertension, and β‐blocker use), was used to compare metabolic stress parameters and 8‐year total mortality (social security index) between both groups. Weighted mean ejection fraction was 58±5.9% in the entire population. After adjusting for unbalanced weighted variables, patients with AF versus those without AF had lower mean peak oxygen consumption (18.5±6.2 versus 20.3±7.1 mL/kg per minute), oxygen pulse (12.4±4.3 versus 12.9±4.7 mL/beat), and circulatory power (2877±1402 versus 3351±1788 mm Hg·mL/kg per minute) (P<0.001 for all comparisons) but similar submaximal exercise capacity (oxygen consumption at anaerobic threshold, 12.0±5.1 versus 12.4±6.0mL/kg per minute; P =0.3). Both groups had similar peak heart rate, whereas mean peak systolic blood pressure was lower in the AF group (150±35 versus 160±51 mm Hg; P<0.001). Moreover, AF was associated with higher total mortality.ConclusionsIn the largest study of its kind, we demonstrate that AF is associated with peak exercise intolerance, impaired contractile reserve, and increased mortality in patients with heart failure with preserved ejection fraction. Whether AF is the primary offender in these patients or merely a bystander to worse diastolic function requires further investigation.
“…During the past few decades, several invasive and noninvasive hemodynamic studies have shed light on the role played by atrial systole and normal sinus rhythm in maintaining adequate cardiac output, particularly during exercise and in patients with heart failure 5, 8, 17, 20, 21, 22, 23. Inadequate cardiac output during AF has been attributed to several mechanisms, including loss of atrial systole, irregular ventricular rhythm with beat‐to‐beat variability, and impaired ventricular filling time 9, 17, 21, 22.…”
BackgroundAtrial fibrillation (AF) has been objectively associated with exercise intolerance in patients with heart failure with reduced ejection fraction; however, its impact in patients with heart failure with preserved ejection fraction has not been fully scrutinized.Methods and ResultsWe identified 1744 patients with heart failure and ejection fraction ≥50% referred for cardiopulmonary stress testing at the Cleveland Clinic (Cleveland, OH), 239 of whom had AF. We used inverse probability of treatment weighting to balance clinical characteristics between patients with and without AF. A weighted linear regression model, adjusted for unbalanced variables (age, sex, diagnosis, hypertension, and β‐blocker use), was used to compare metabolic stress parameters and 8‐year total mortality (social security index) between both groups. Weighted mean ejection fraction was 58±5.9% in the entire population. After adjusting for unbalanced weighted variables, patients with AF versus those without AF had lower mean peak oxygen consumption (18.5±6.2 versus 20.3±7.1 mL/kg per minute), oxygen pulse (12.4±4.3 versus 12.9±4.7 mL/beat), and circulatory power (2877±1402 versus 3351±1788 mm Hg·mL/kg per minute) (P<0.001 for all comparisons) but similar submaximal exercise capacity (oxygen consumption at anaerobic threshold, 12.0±5.1 versus 12.4±6.0mL/kg per minute; P =0.3). Both groups had similar peak heart rate, whereas mean peak systolic blood pressure was lower in the AF group (150±35 versus 160±51 mm Hg; P<0.001). Moreover, AF was associated with higher total mortality.ConclusionsIn the largest study of its kind, we demonstrate that AF is associated with peak exercise intolerance, impaired contractile reserve, and increased mortality in patients with heart failure with preserved ejection fraction. Whether AF is the primary offender in these patients or merely a bystander to worse diastolic function requires further investigation.
“…The initial study to address this important topic was
published in 2004. 232,1042 This study examined the
role of catheter ablation in 58 patients with HF with an EF of less than
45% and 58 controls. During a mean follow-up of 12 ± 7 months,
78% of patients with HF and 84% of controls remained in sinus
rhythm.…”
Section: Outcomes Of Af Ablation In Populations Not Well Represented mentioning
confidence: 99%
“…1193 Injury to the left PN
during isolation of a persistent left SVC was not observed in several case
series using RF energy. 232,1042,1194,1195 Very rarely, ablation at the roof of the LAA can
result in left PN damage 1184 ; however, it was not observed in a large study in which LAA
isolation was performed using RF ablation. 532,533 The
incidence of PN palsy is 0.17%–0.48% with PV antrum
isolation using RF ablation, even though the PN is found within the typical WACA
and carina lines of the right-sided PVs in 30% of patients.…”
“…In addition, results from several trials suggest that early restoration and long-term maintenance of sinus rhythm provides considerable benefits, including improvement in cardiac function and quality of life and a lower risk of death in select populations. [27][28][29][30] Furthermore, a recent study in patients with long-standing PeAF suggested that transformation from nonparoxysmal to PAF after catheter ablation may …”
Background-Atrial fibrillation (AF) type can vary depending on condition and timing, and some patients who initially present with persistent AF may be changed to paroxysmal AF after antiarrhythmic drug medication and cardioversion. We investigated whether circumferential pulmonary vein isolation (CPVI) alone is an effective rhythm control strategy in patients with persistent AF to paroxysmal AF. Methods and Results-We enrolled 113 patients with persistent AF to paroxysmal AF (male 75%, 60.4±10.1 years old) who underwent catheter ablation for nonvalvular AF at 3 tertiary hospitals. The participants were randomly assigned to 2 groups: CPVI alone (n=59) or CPVI plus linear ablation (CPVI+Line; posterior box+anterior line, n=54
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