Cathepsin B, Cathepsin H, Cathepsin X and Cystatin C in Sera of                     Patients with Early-Stage and Inflammatory Breast Cancer

Decock, Julie; Obermajer, Natasja; Vozelj, S; Hendrickx, Wouter; Paridaens, Robert; Kos, Janko

doi:10.1177/172460080802300305

Cited by 62 publications

(30 citation statements)

References 33 publications

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“…As shown by our group, significantly lower levels of active Cat X were found in serum of patients with inflammatory breast cancer compared to non-inflammatory breast cancer 22. In cyst fluid from epithelial ovarian cancer we did not find a significant correlation of the levels of active Cat X with any clinico-pathological parameter 23.…”

Section: Introductioncontrasting

confidence: 42%

Cathepsin X in serum from patients with colorectal cancer: relation to prognosis

Vizin¹,

Christensen²,

Nielsen³

et al. 2012

Radiology and Oncology

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BackgroundUp-regulation of lysosomal cysteine protease cathepsin X (Cat X) is associated with disorders of the immune system and neurodegenerative diseases, while its role in the development and progression of cancer is less understood. Enhanced secretion of pro-Cat X was observed in malignant processes, and therefore, the level of total serum Cat X rather than the active enzyme may better reflect the tumour status.Patients and methodsSeventy-seven patients with colorectal cancer (CRC) were included in a retrospective study. Blood samples were collected prior to therapy. Using ELISA, the values of total Cat X were measured in serum. Groups of healthy persons (n=77), patients with adenomas (n=77) and patients with non-neoplastic findings (n=77) were included.ResultsSignificant differences between the group of colorectal patients and the groups of healthy persons, adenoma patients and patients with non-malignant findings could not be shown (p=0.89). Within the group of CRC, higher levels of total Cat X significantly correlated to shorter overall survival (HR=2.08, 95% CI:1.07–4.05, p=0.028).ConclusionsTotal serum Cat X could be a useful prognostic indicator for determining survival of patients with CRC. Increased serum levels of total Cat X may reflect more aggressive tumour cell phenotypes and suggest the involvement of Cat X in processes involved in later stages of tumour progression.

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Section: Introductioncontrasting

confidence: 42%

Cathepsin X in serum from patients with colorectal cancer: relation to prognosis

Vizin¹,

Christensen²,

Nielsen³

et al. 2012

Radiology and Oncology

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“…Cathepsins, a specific class of lysosomal enzymes, have been shown to be significantly involved in mediating the inflammatory response and cholesterol trafficking464748. Furthermore, we have recently reported that plasma CatD was strongly associated with pediatric NASH11.…”

Section: Discussionmentioning

confidence: 97%

Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention

Walenbergh

Houben

Rensen

et al. 2016

Sci Rep

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Non-alcoholic steatohepatitis (NASH) is characterized by liver lipid accumulation and inflammation. The mechanisms that trigger hepatic inflammation are poorly understood and subsequently, no specific non-invasive markers exist. We previously demonstrated a reduction in the plasma lysosomal enzyme, cathepsin D (CatD), in children with NASH compared to children without NASH. Recent studies have raised the concept that non-alcoholic fatty liver disease (NAFLD) in adults is distinct from children due to a different histological pattern in the liver. Yet, the link between plasma CatD to adult NASH was not examined. In the current manuscript, we investigated whether plasma CatD in adults correlates with NASH development and regression. Biopsies were histologically evaluated for inflammation and NAFLD in three complementary cohorts of adults (total n = 248). CatD and alanine aminotransferase (ALT) were measured in plasma. Opposite to our previous observations with childhood NASH, we observed increased levels of plasma CatD in patients with NASH compared to adults without hepatic inflammation. Furthermore, after surgical intervention, we found a reduction of plasma CatD compared to baseline. Our observations highlight a distinct pathophysiology between NASH in children and adults. The observation that plasma CatD correlated with NASH development and regression is promising for NASH diagnosis.

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“…Therefore, it is believed that CysC played a negative role in cancer invasion and migration, at least in some types of cancers. However, some other studies indicated that high serum CysC level was related with poor prognosis and it could promote the progression of several cancers [24, 30]. Moreover, cathepsin B, one of major cathepsins inhibited by CysC, was demonstrated to be a protease with caspase-processing activity and an pro-apoptotic and –inflammatory cathepsin member [6, 31].…”

Section: Discussionmentioning

confidence: 99%

LncRNA Snhg1, a non-degradable sponge for miR-338, promotes expression of proto-oncogene CST3 in primary esophageal cancer cells

et al. 2017

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Competing endogenous RNA (ceRNA) is a newly proposed mechanism that describes a crosstalk among lncRNAs, mRNAs and their shared miRNAs. In this study, the role of miR-338-3p (miR-338) in the progression of esophageal cancer and its involve in the ceRNA regulatory circuit lncRNA-Snhg1/CST3 were explored. MiR-338 displayed a 30% decreased expression in esophageal squamous cell carcinoma tissues compared with the adjacent. Then, proto-oncogene CST3 was predicted and validated as a target gene of miR-338. Gain-and-loss-function experiments indicated that miR-338 suppressed expression of CST3 protein (also Cystatin C, CysC), promoted expression of apoptotic proteins caspase-8/3, attenuated esophageal carcinoma cell growth and induced its apoptosis. In addition, lncRNA-Snhg1 was significantly upregulated in esophageal carcinoma tissues and promoted esophageal carcinoma cell growth. Furthermore, our results from bioinformatics, luciferase reporter gene and RNA pull-down assays indicated that Snhg1 could be directly bound by miR-338. Snhg1 acted as a non-degradable sponge to relieve the suppression on CST3 caused by miR-338. In conclusion, lncRNA-Snhg1 promoted cell proliferation by acting as a non-degradable sponge for the tumor suppressor miR-338 in esophageal cancer cells.

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Cathepsin B, Cathepsin H, Cathepsin X and Cystatin C in Sera of Patients with Early-Stage and Inflammatory Breast Cancer

Cited by 62 publications

References 33 publications

Cathepsin X in serum from patients with colorectal cancer: relation to prognosis

Cathepsin X in serum from patients with colorectal cancer: relation to prognosis

Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention

LncRNA Snhg1, a non-degradable sponge for miR-338, promotes expression of proto-oncogene CST3 in primary esophageal cancer cells

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