Cathepsin B and H activities and cystatin C concentrations in cerebrospinal fluid from patients with leptomeningeal metastasis

Nagai, Atsushi; Terashima, Masaharu; Harada, Takayuki; Shimode, Koichi; Takeuchi, Hiromi; Murakawa, Yohko; Nagasaki, Makoto; Nakano, Akinobu; Kobayashi, Shotai

doi:10.1016/s0009-8981(03)00023-8

Cited by 63 publications

(39 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 A previous study that measured cystatin C levels in CSF of MS patients by enzyme-linked immunosorbent assay also found diminished levels in patients compared with healthy controls. Conversely, levels of cathepsin B were increased in CSF and brain of patients with MS. 13,14 In contrast, although we did not have access to totally normal CSF, our studies did not show any significant difference between the cystatin C levels in the MS patients compared with patients with ONDs. Interestingly, other studies have shown that cystatin C levels are increased in the CSF of patients with Alzheimer's disease 7 and Creutzfeldt-Jakob disease.…”

Section: Discussioncontrasting

confidence: 67%

Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosis

Irani

Anderson

Gundry

et al. 2006

Annals of Neurology

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 67%

Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosis

Irani

Anderson

Gundry

et al. 2006

Annals of Neurology

View full text Add to dashboard Cite

show abstract

“…CTSB expression on the gene and protein level has been correlated with metastasis (38,39); however, little is known about the functional relevance of CTSB for the metastatic process in vivo. In the present study, the role of cancer cell-derived CTSB has been addressed by analysis of spontaneous pulmonary metastases as well as lung metastases, resulting from introduction of primary PyMT cells of different CTSB genotypes and ex vivo migration/ invasion of isolated PyMT tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Tumor Cell–Derived and Macrophage-Derived Cathepsin B Promotes Progression and Lung Metastasis of Mammary Cancer

Vasiljeva¹,

Papazoglou²,

et al. 2006

View full text Add to dashboard Cite

Proteolysis in close vicinity of tumor cells is a hallmark of cancer invasion and metastasis. We show here that mouse mammary tumor virus-polyoma middle T antigen (PyMT) transgenic mice deficient for the cysteine protease cathepsin B (CTSB) exhibited a significantly delayed onset and reduced growth rate of mammary cancers compared with wild-type PyMT mice. with PyMT;ctsb +/+ cells, was used to address the role of stroma-derived CTSB in lung metastasis formation. Notably, ctsb À/À mice showed reduced number and volume of lung colonies, and infiltrating macrophages showed a strongly up-regulated expression of CTSB within metastatic cell populations. These results indicate that both cancer cellderived and stroma cell-derived (i.e., macrophages) CTSB plays an important role in tumor progression and metastasis.

show abstract

“…There are two forms of cathepsin B, namely, non-glycosylated or single-chain form (27 kDa) and glycosylated or two-chain form (28-30 kDa) (Mach et al, 1992;Iacobuzio-Donahue et al, 1997). It is secreted and detected in the biological fluid of inflammatory diseases and many cancers (Claus et al, 1998;Nagai et al, 2003;Chu et al, 2004;Strojan et al, 2004;Tsai et al, 2009). Cathepsin B is regulated by cysteine protease inhibitors, including cystatin C and stefin A (Sloane, 1990).…”

Section: Introductionmentioning

confidence: 99%

“…Cathepsin B is regulated by cysteine protease inhibitors, including cystatin C and stefin A (Sloane, 1990). Imbalances between proteinases and their inhibitors correlated with tumor progression (Calkins and Sloane, 1995), and the measurement of cathepsin B and cystatin C levels has been suggested to be beneficial for prognosis or diagnosis of diseases (Nagai et al, 2003). The serum level of cathepsin B may serve as a prognostic factor for patients with advanced melanoma (Kos et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Serum Cathepsin B to Cystatin C Ratio as a Potential Marker for the Diagnosis of Cholangiocarcinoma

Monsouvanh

Proungvitaya²,

Limpaiboon³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Cholangiocarcinoma (CCA) is a cancer of the bile duct epithelial cells. The highest incidence rate of CCA with a poor prognosis and poor response to chemotherapy is found in Southeast Asian countries, especially in northeastern Thailand and Lao PDR. Cathepsin B is a lysosomal cysteine protease which is regulated by cysteine proteinase inhibitors such as cystatin C. Elevation of cathepsin B levels in biological fluid has been observed in patients with inflammatory diseases and many cancers. We aimed to investigate the serum cathepsin B and cystatin C levels of CCA patients to evaluate the feasibility of using cathepsin B and cystatin C as markers for the diagnosis of CCA. Fifty-six sera from CCA patients, 17 with benign biliary diseases (BBD) and 13 from controls were collected and the cathepsin B and cystatin C levels were determined. In addition, cathepsin B expression was investigated immunohistochemically for 9 matched-pairs of cancerous and adjacent tissues of CCA patients. Serum cathepsin B, but not cystatin C, was significantly higher in CCA and BBD patient groups compared to that in the control group. Consistently, all cancerous tissues strongly expressed cathepsin B while adjacent tissues were negative in 7 out of 9 cases. In contrast, serum cystatin C levels were comparable between CCA and control groups, although serum cystatin C levels in the BBD group was higher than that in the control or CCA groups. When the serum cathepsin B to cystatin C ratio was calculated, that of the CCA group was significantly higher than that of the control group, and, although statistically not significant, the ratio of CCA group showed a trend to be higher than that of the BBD group. Thus, the cathepsin B to cystatin C ratio might be used as an alternative marker for aiding diagnosis of CCA.

show abstract

Cathepsin B and H activities and cystatin C concentrations in cerebrospinal fluid from patients with leptomeningeal metastasis

Cited by 63 publications

References 20 publications

Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosis

Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosis

Tumor Cell–Derived and Macrophage-Derived Cathepsin B Promotes Progression and Lung Metastasis of Mammary Cancer

Serum Cathepsin B to Cystatin C Ratio as a Potential Marker for the Diagnosis of Cholangiocarcinoma

Contact Info

Product

Resources

About