Catharticinduced Fatal Hypermagnesemia in the Elderly

Onishi, Sachiko; Yoshino, Shunpei

doi:10.2169/internalmedicine.45.1482

Cited by 57 publications

(56 citation statements)

References 12 publications

(9 reference statements)

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“…The degree of hyperkalaemia remained relatively constant. The increase in magnesium observed is of potential importance as this increase may be associated with clinically relevant complications in patients with pre-existing high levels [21]. The increase in serum magnesium, while without clinical sequelae in our study, would call for caution and appropriate monitoring of magnesium levels in elderly frail patients, as studied in the current study.…”

Section: Discussionmentioning

confidence: 62%

Bowel preparation in CT colonography: electrolyte and renal function disturbances in the frail and elderly patient

et al. 2009

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Section: Discussionmentioning

confidence: 62%

Bowel preparation in CT colonography: electrolyte and renal function disturbances in the frail and elderly patient

et al. 2009

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“…Hypermagnesemia, which may be fatal, is frequently iatrogenic due to administration of magnesium-containing cathartics and elderly patients and those with bowel disorders or renal insufficiency may be at a higher risk. [17][18][19] We failed to locate studies addressing the prognostic significance of hypermagnesemia in a population of patients with advanced cancer. In one study, ionized hypermagnesemia was associated with a significantly higher mortality rate in critically ill patients.…”

Section: Discussionmentioning

confidence: 99%

Predictive Impact of Electrolyte Abnormalities on the Admission Outcome and Survival of Palliative Care Cancer Referrals

Alsirafy

Sroor

Al-Shahri

2009

Journal of Palliative Medicine

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“…However, hemodialysis and IV calcium gluconate may be required in high risk patients with renal dysfunctions, bowel obstruction [27], or in elderly patients taking magnesium-containing cathartics [28]. …”

Section: Introductionmentioning

confidence: 99%

Magnesium sulfate for acute asthma in adults: a systematic literature review

Song

Chang

2012

Asia Pacific Allergy

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Magnesium sulfate (MgSO4) has been considered as an adjunct therapy for severe and life-threatening asthma exacerbation. The literature search was performed using MEDLINE, EMBASE, Cochrane Library and Google Scholar to summarize the current state of knowledge regarding magnesium therapy in acute exacerbation of adult asthma. A total of 16 trials and 4 meta-analyses were identified. As results, intravenous MgSO4 was beneficial in severe exacerbation, but evidence for nebulized magnesium was insufficient. However, larger trials are required to draw confirmative conclusions on the efficacy. Regarding the safety concern, the risk of major toxicity appears to be very low at usual doses described in the literature. Additionally, results from 4 surveys were examined on the gaps between knowledge and practice, and on the barrier to the use of MgSO4 at emergency departments. This literature review summarized the up-to-date evidence on the issues regarding the use of MgSO4 for acute asthma. We expect more studies to be conducted for evidence making in the Asian-Pacific regions.

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Catharticinduced Fatal Hypermagnesemia in the Elderly

Abstract: Abstract

Cited by 57 publications

References 12 publications

Bowel preparation in CT colonography: electrolyte and renal function disturbances in the frail and elderly patient

Bowel preparation in CT colonography: electrolyte and renal function disturbances in the frail and elderly patient

Predictive Impact of Electrolyte Abnormalities on the Admission Outcome and Survival of Palliative Care Cancer Referrals

Magnesium sulfate for acute asthma in adults: a systematic literature review

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