Categorization and association analysis of risk factors for adverse drug events

Zhou, Lina; Rupa, Anamika Paul

doi:10.1007/s00228-017-2373-5

Cited by 30 publications

(19 citation statements)

References 142 publications

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“…Risk factors are defined as conditions or measurements associated with the probability of disease or death not necessarily recognized by the patient [15] [16] [17]. Managing risk factors for ADRs is crucial for improving patient safety, particularly for the elderly, comorbid, and polypharmacy patients [18]. ADRs have risk factors, and some are preventable.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Adverse Drug Reactions to Second Line Anti Tuberculosis Drugs in Nigeria: A Cross-Sectional Study

Ganiyu¹,

Avong²,

Akinyede³

et al. 2021

JTR

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Introduction: Multidrug resistant tuberculosis (MDR-TB) is treated with second line antituberculosis drugs. These drugs are notorious for inflicting serious adverse drug reactions (ADRs), which many studies have shown causes a wide range of economic and health problems including death. Aim: The study examined the prevalence of ADRs, associated risk factors, sociodemographic association and outcomes among patients treated for MDR-TB at a comprehensive tuberculosis treatment center in Nigeria. Method: The study was conducted at the Government Chest Hospital, Jericho, Ibadan. We applied a retrospective assessment of patient treatment data and ADRs reports stored at the study site from March 2013 and February 2016. Subsequently, a prospective study of ADRs was conducted on patients admitted into the same hospital. Causality relationship between the drugs and the reported ADRs was determined with a specially validated tool. The outcomes assessed include recovery from the ADRs, death and permanent deafness from the ADRs. Extracted data were analyzed using SPSS version 22.0. Risk Ratio was calculated for the influence of risk factors for adverse drug reactions. Logistic regression was performed to test for the strength of relationships between risk factors and incidence of ADRs among patients. Result: Almost all the participants in this study reported adverse drug reaction [99% (118/119)]. However, ototoxicity was the most prevalent ADR (35.3%), followed by electrolyte imbalance (12.6%), gastrointestinal track (10.1%

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Section: Introductionmentioning

confidence: 99%

Prevalence of Adverse Drug Reactions to Second Line Anti Tuberculosis Drugs in Nigeria: A Cross-Sectional Study

Ganiyu¹,

Avong²,

Akinyede³

et al. 2021

JTR

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“…Elderly age and concomitant drug use are known risk factors for ADRs. 15 Because women tend to live longer than men and take more medications simultaneously, this can induce additional synthetic associations.…”

Section: Introductionmentioning

confidence: 99%

Using Machine Learning to Identify Adverse Drug Effects Posing Increased Risk to Women

Chandak

Tatonetti

2020

Patterns

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SUMMARY Adverse drug reactions are the fourth leading cause of death in the US. Although women take longer to metabolize medications and experience twice the risk of developing adverse reactions compared with men, these sex differences are not comprehensively understood. Real-world clinical data provide an opportunity to estimate safety effects in otherwise understudied populations, i.e., women. These data, however, are subject to confounding biases and correlated covariates. We present AwareDX, a pharmacovigilance algorithm that leverages advances in machine learning to predict sex risks. Our algorithm mitigates these biases and quantifies the differential risk of a drug causing an adverse event in either men or women. AwareDX demonstrates high precision during validation against clinical literature and pharmacogenetic mechanisms. We present a resource of 20,817 adverse drug effects posing sex-specific risks. AwareDX, and this resource, present an opportunity to minimize adverse events by tailoring drug prescription and dosage to sex.

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“…Data from the USA reveal that adverse drug effects may account for up to 140 000 deaths annually, whereas about 10‐15% of bed days are due to adverse drug reactions or hospital‐acquired infections . However, many ADEs could be prevented or ameliorated through simple strategies . As clinical pharmacists possess an extensive knowledge on drug therapy, monitor ADEs and improve inappropriate prescribing, their participation in a multidisciplinary team is important to prevent or mitigate drug‐related adverse reactions.…”

Section: Resultsmentioning

confidence: 99%

“…Challenges for modern health care include inappropriate drug use, medication errors and adverse drug events (ADEs), for which the risk factors are regarded as the patients' age, polypharmacy, care transitions, frequent medication changes and a higher number of previous operations . On the one hand, polypharmacy becomes more complex for older patient, and orthopaedic patients are often not only elderly but also prescribed an average of six pre‐admission medications .…”

Section: What Is Known and Objectivementioning

confidence: 99%

Impact of pharmaceutical care in the orthopaedic department

Xie

et al. 2019

J Clin Pharm Ther

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What is known and objective In the mid‐1960s, clinical pharmacy developed in the USA, and as the demand for pharmaceutical services continued to grow, their impact began to be taken seriously. However, the participation of clinical pharmacists as members of the multidisciplinary team in the orthopaedic department is still in its infancy, although its role in orthopaedics has not been defined. The object of this study was to identify and discuss the impact of pharmaceutical care in the orthopaedic department. Methods A literature search was conducted on MEDLINE, PubMed, Web of Science, the Cochrane Library and CNKI (China National Knowledge Infrastructure) for papers published between 1998 and 2019, using the keywords pharmacy, pharmacist, and medication or drug combined with orthopaedic. Other available resources were also used to identify relevant articles. Results and discussion Based on the available evidence in 74 articles, it was found that clinical pharmacists play an important role in all aspects of rational use of medications, medication review and reconciliation, monitoring adverse drug events, risk assessment, and medication education and counselling. In addition, clinical pharmacy services were developed to minimize medication errors, adverse drug events and medical costs, but clinical pharmacy is still in its early stages in orthopaedics. What is new and conclusion A multidisciplinary approach should be adopted in the orthopaedic department, as pharmacist interventions can be vital for promoting the safety, effectiveness and cost‐effectiveness of pharmacotherapy. Although pharmacists' contributions to orthopaedics are not yet fully recognized, pharmaceutical services can undoubtedly contribute to both clinical and societal outcomes.

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Categorization and association analysis of risk factors for adverse drug events

Cited by 30 publications

References 142 publications

Prevalence of Adverse Drug Reactions to Second Line Anti Tuberculosis Drugs in Nigeria: A Cross-Sectional Study

Prevalence of Adverse Drug Reactions to Second Line Anti Tuberculosis Drugs in Nigeria: A Cross-Sectional Study

Using Machine Learning to Identify Adverse Drug Effects Posing Increased Risk to Women

Impact of pharmaceutical care in the orthopaedic department

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