Catecholamines in Post-traumatic Stress Disorder: A Systematic Review and Meta-Analysis

Pan, Xiongfeng; Kaminga, Atipatsa Chiwanda; Wen, Shi Wu; Liu, Aizhong

doi:10.3389/fnmol.2018.00450

Cited by 73 publications

(47 citation statements)

References 85 publications

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“…This is consistent with results of a previous study, suggesting that the increased risk for developing PTSD is associated with lower concentrations of cortisol in both adults and children [44]. That is, during childhood, trauma exposure may have greater potential of devastating HPA, disrupting brain maturation and affecting the development of the frontal cortex, leading to long-term changes in the HPA response [45]. This may be related to prefrontal cortex development, corpus callosum myelination, and synaptic elimination in the developmental traumatology models.…”

Section: Discussionsupporting

confidence: 92%

The 24-hour urinary cortisol in post-traumatic stress disorder: A meta-analysis

et al. 2020

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Previous studies found inconsistent results on the relationship between post-traumatic stress disorder (PTSD) and concentrations of 24-hour (24-h) urinary cortisol. This study performed a systematic review and meta-analysis to summarize previous findings on this relationship. Methods We searched in the databases of Web of Science, PubMed, Embase, and Psyc-ARTICLES for articles published before September 2018. We used the random-effects model with restricted maximum-likelihood estimator to synthesize the effect sizes by calculating the standardized mean difference (SMD) and assessing its significance. Results Six hundred and nineteen articles were identified from the preceding databases and 20 of them were included in the meta-analysis. Lower concentrations of 24-h urinary cortisol were observed in patients with PTSD when compared with the controls (SMD =-0.49, 95%CI [-0.91;-0.07], p = 0.02). Subgroup analysis revealed that the concentrations of 24-h urinary cortisol were lower in PTSD patients than in the controls for studies that included female participants or studies that included participants from the United States of America. Conclusions Overall, decreased levels of 24-h urinary cortisol were linked with the pathophysiology of PTSD. Nonetheless, more studies should be conducted to validate the molecular underpinnings of urine cortisol degeneration in PTSD.

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Section: Discussionsupporting

confidence: 92%

The 24-hour urinary cortisol in post-traumatic stress disorder: A meta-analysis

et al. 2020

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“…The standardized mean differences (SMDs) with 95% confidence interval (CI) were calculated from continuous data in networks (14,15). The degree of heterogeneity per network was assessed by comparing the size of the network's τ and generating adjusted funnel plots to assess the publication bias (16,17). Meanwhile, in order to evaluate the robustness of the results obtained from the preliminary model, a sensitivity analysis was performed by excluding one study at a time.…”

Section: Discussionmentioning

confidence: 99%

Chemokines in Non-alcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis

et al. 2020

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Background: Previous results on the relationship between non-alcoholic fatty liver disease (NAFLD) and chemokine concentrations were inconsistent. The purpose of this network meta-analysis was to evaluate the link between chemokine system and NAFLD. Methods: Relevant data, published not later than June 31, 2019, were searched in the databases of PubMed, Embase, Cochrane Library, and Web of Science. A network meta-analysis was used to rank the chemokines by surface under the cumulative ranking (SUCRA) probabilities. In addition, standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated as group differences in the chemokine concentrations. Results: The search in the databases identified 46 relevant studies that investigated the relationship between 15 different chemokines and NAFLD using 4,753 patients and 4,059 controls. Results from the network meta-analysis showed that the concentrations of CCL2 and CXCL8 in the non-alcoholic fatty liver (NAFL) group was significantly higher than that in the control group (SMDs of 1.51 and 1.95, respectively), and the concentrations of CCL3, CCL4, CCL20, CXCL8, and CXCL10 in the non-alcoholic steatohepatitis (NASH) group was significantly higher than that in the control group (SMDs of 0.90, 2.05, 2.16, 0.91, and 1.46, respectively). SUCRA probabilities showed that CXCL8 had the highest rank in NAFL for all chemokines and CCL20 had the highest rank in NASH for all chemokines. Conclusion: Elevated concentrations of CCL2, CCL4, CCL20, CXCL8, and CXCL10 may be associated with NAFL or NASH. In this regard, more population-based studies are needed to ascertain this hypothesis.

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“…The means and corresponding standard deviations (SDs) for DHEA concentrations were converted to nmol/mL, whereas for DHEA-S they were converted to μmol/mL. Then the standardized mean differences (SMD) with corresponding 95% confidence intervals (CIs) were calculated to evaluate the strength of the relationship between AD and the concentrations DHEA and DHEA-S (Higgins et al, 2003; Pan et al, 2018a). The effect size was considered large when SMD was >0.8, moderate when it was between 0.5 and 0.8, and low when it was lower than 0.5.…”

Section: Methodsmentioning

confidence: 99%

Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate in Alzheimer's Disease: A Systematic Review and Meta-Analysis

Pan

Kaminga

et al. 2019

Front. Aging Neurosci.

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Background and Purpose: Previous studies found inconsistent results for the relationship between Alzheimer's disease and the levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate. This study performed a systematic review and meta-analysis to evaluate previous studies' results on this relationship. Method: Studies related to this outcome were obtained using a systematic search from the electronic databases of PubMed, Embase, Web of Science, and Psyc-ARTICLES in March 2018. The random-effects model was used to measure the strength of the association between Alzheimer's disease and the levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate, using the standardized mean difference. Results: Thirty-one eligible studies were included in the final analysis. There was no statistically significant association between the level of dehydroepiandrosterone and Alzheimer's disease (standardized mean difference: 0.51, 95% confidence interval: −0.44 to 1.45, Z = 1.06, p = 0.29). On the other hand, lower level dehydroepiandrosterone sulfate was observed in patients with Alzheimer's disease than in controls (standardized mean difference: −0.69, 95% confidence interval: −1.17 to −0.22, Z = −2.84, p < 0.01). Conclusion: Decreased dehydroepiandrosterone sulfate concentrations may be an important indicator for Alzheimer's disease, although whether dehydroepiandrosterone sulfate could be used as a diagnostic tool requires further research.

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Catecholamines in Post-traumatic Stress Disorder: A Systematic Review and Meta-Analysis

Cited by 73 publications

References 85 publications

The 24-hour urinary cortisol in post-traumatic stress disorder: A meta-analysis

The 24-hour urinary cortisol in post-traumatic stress disorder: A meta-analysis

Chemokines in Non-alcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis

Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate in Alzheimer's Disease: A Systematic Review and Meta-Analysis

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