Catecholamines in peripheral tissues of mice and cell counts of sympathetic ganglia after the prenatal and postnatal administration of the nerve growth factor antiserum

Klingman, Gerda I.; Klingman, Jack D.

doi:10.1016/0028-3908(67)90050-0

Cited by 38 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SCG and other sympathetic ganglia are affected not only by postnatal, but also by prenatal application of the antiserum (Klingman and Klingman 1967). Injection of antiserum into pregnant mice at days 15, 16 and 17 leads tõ 80% cell loss in STG and SCG of progeny analysed postnatally.…”

Section: Functional Analysis Of Nt Signalling In the Sympathetic Systemmentioning

confidence: 99%

“…Conversely, prenatal or postnatal injection of anti-NGF antiserum in mice leads to reduced catecholamine levels in sympathetic target tissues (Klingman and Klingman 1967). The reduction of catecholamine levels in target tissues after antiserum injection in postnatal rats correlates with the reduction of the ability of these tissues to take up radiolabelled noradrenalin (Zaimis et al 1965).…”

Section: Ngf Availability Promotes Peripheral Innervationmentioning

confidence: 99%

See 1 more Smart Citation

Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia

2009

View full text Add to dashboard Cite

Manipulation of neurotrophin (NT) signalling by administration or depletion of NTs, by transgenic overexpression or by deletion of genes coding for NTs and their receptors has demonstrated the importance of NT signalling for the survival and differentiation of neurons in sympathetic and dorsal root ganglia (DRG). Combination with mutation of the proapoptotic Bax gene allows the separation of survival and differentiation effects. These studies together with cell culture analysis suggest that NT signalling directly regulates the differentiation of neuron subpopulations and their integration into neural networks. The high-affinity NT receptors trkA, trkB and trkC are restricted to subpopulations of mature neurons, whereas their expression at early developmental stages largely overlaps. trkC is expressed throughout sympathetic ganglia and DRG early after ganglion formation but becomes restricted to small neuron subpopulations during embryogenesis when trkA is turned on. The temporal relationship between trkA and trkC expression is conserved between sympathetic ganglia and DRG. In DRG, NGF signalling is required not only for survival, but also for the differentiation of nociceptors. Expression of neuropeptides calcitonin gene-related peptide and substance P, which specify peptidergic nociceptors, depends on nerve growth factor (NGF) signalling. ret expression indicative of nonpeptidergic nociceptors is also promoted by the NGFsignalling pathway. Regulation of TRP channels by NGF signalling might specify the temperature sensitivity of afferent neurons embryonically. The manipulation of NGF levels "tunes" heat sensitivity in nociceptors at postnatal and adult stages. Brain-derived neurotrophic factor signalling is required for subpopulations of DRG neurons that are not fully characterized; it affects mechanical sensitivity in slowly adapting, low-threshold mechanoreceptors and might involve the regulation of DEG/ENaC ion channels. NT3 signalling is required for the generation and survival of various DRG neuron classes, in particular proprioceptors. Its importance for peripheral projections and central connectivity of proprioceptors demonstrates the significance of NT signalling for integrating responsive neurons in neural networks. The molecular targets of NT3 signalling in proprioceptor differentiation remain to be characterized. In sympathetic ganglia, NGF signalling regulates dendritic development and axonal projections. Its role in the specification of other neuronal properties is less well analysed. In vitro analysis suggests the involvement of NT signalling in the choice between the noradrenergic and cholinergic transmitter phenotype, in the expression of various classes of ion channels and for target connectivity. In vivo analysis is required to show the degree to which NT signalling regulates these sympathetic neuron properties in developing embryos and postnatally.

show abstract

Section: Functional Analysis Of Nt Signalling In the Sympathetic Systemmentioning

confidence: 99%

Section: Ngf Availability Promotes Peripheral Innervationmentioning

confidence: 99%

Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia

2009

View full text Add to dashboard Cite

show abstract

“…This scenario is partly analogous to that found in the peripheral nervous system, where sympathetic axons do not rely on NGF for outgrowth and target innervation during in utero development (Hoyle et al, 1993). When sympathetic axons reach these target tissues prenatally, however, they do become dependent on NGF production for the arborization of terminal branches (Klingman & Klingman, 1967;Hoyle et al, 1993). Increasing local levels of NGF within peripheral organs during postnatal development can further enhance the degree of axonal arborization and target hyperinnervation (Edwards et al, 1989;Albers et al, 1994).…”

Section: Nerve Growth Factor and Septal Efferents In The Dorsal Hippomentioning

confidence: 55%

“…1993). When sympathetic axons reach these target tissues prenatally, however, they do become dependent on NGF production for the arborization of terminal branches (Klingman & Klingman 1967;Hoyle et al . 1993).…”

Section: Discussionmentioning

confidence: 99%

Effects of elevated levels of nerve growth factor on the septohippocampal system in transgenic mice

Kawaja

Walsh

Tovich

et al. 1998

Eur J of Neuroscience

View full text Add to dashboard Cite

Elevating target-derived levels of nerve growth factor (NGF) in peripheral organs of postnatal mammals is known to enhance the survival of postganglionic sympathetic neurons and to promote the terminal arborization of sympathetic axons within such NGF-rich target tissues. Although increasing levels of NGF in the central nervous system can ameliorate cholinergic function of damaged and aged neurons of the medial septum, it remains undetermined whether the postnatal development of this neuronal population and their projections that innervate the hippocampus are likewise affected by elevated levels of target-derived NGF. To address this question, the cholinergic septohippocampal pathway was examined in adult transgenic mice which display elevated levels of NGF protein production in the dorsal hippocampus during postnatal development. Adult transgenic mice possessed a cholinergic population of septal neurons approximately 15% larger than that seen in age-matched control animals. Despite increased numbers of cholinergic septal neurons, as well as elevated levels of hippocampal NGF, the density of cholinergic septal axons in the outer molecular layer of the hippocampal dentate gyrus of adult transgenic animals was comparable with that found in wild-type controls. These results reveal that elevating levels of target-derived NGF during postnatal development can increase the population size of the cholinergic septal neurons but does not alter their pattern of afferent innervation in the hippocampus of adult mice.

show abstract

“…During development nerve growth factor (NGF) is required for the survival of sympathetic neurons (LeviMontalcini and Booker, 1960;Klingman and Klingman, 1967) and certain populations of sensory neurons Aloe et al, 1981;Goedert et al, 1984). The morphological phenotype of sympathetic neurons is also regulated by NGF, not only in the neonate (Ruit and Snider, 1991) but also in the adult (Bjerre et al, 1975;Snider, 1988;Ruit et al, 1990).…”

mentioning

confidence: 98%

NGF‐dependent and NGF‐independent recovery of sympathetic function after chemical sympathectomy with 6‐hydroxydopamine

Gloster

Diamond

1995

J of Comparative Neurology

View full text Add to dashboard Cite

To help clarify the distinction between the nerve growth factor (NGF)-dependent collateral sprouting of sympathetic nerves and their NGF-independent regeneration after crush, we used 6-hydroxydopamine (OHDA) to destroy the sympathetic terminals in adult rats; this leaves the axons damage-free. Would recovery occur by regeneration and/or collateral sprouting? A single 6-OHDA injection abolished the sympathetic pilomotor field revealed by electrical stimulation of a cutaneous nerve. Recovery began within 2 days, and by 20 days the field was reestablished. If the field was "isolated" by adjacent denervations at the time of 6-OHDA treatment, the recovering pilomotor field expanded extensively into the surrounding territory. In the presence of anti-NGF, however, the pilomotor field expansion ceased at about 60% of its former size; if anti-NGF treatment was discontinued, expansion recommended and extended into the surrounding skin. We suggest that the latter, NGF-dependent, growth phase corresponds to collateral sprouting, and the initial NGF-independent one to regeneration. After simple nerve crush, however, such regeneration can triple the normal sympathetic field size. This difference between crush- and 6-OHDA-induced regeneration might relate to the "cell body reaction" (CBR); the CBR is reduced with increasing distance of the lesion and is undetectable after a 6-OHDA lesion. Since the CBR and the vigor of regeneration are both increased by repeated axonal injury, we tested the effects of multiple 6-OHDA treatments; this significantly increased the initial NGF-independent expansion. We hypothesize that regeneration is regulated largely by mechanisms associated with the CBR, and that neurotrophin-dependent collateral sprouting occurs independently of these.

show abstract

Catecholamines in peripheral tissues of mice and cell counts of sympathetic ganglia after the prenatal and postnatal administration of the nerve growth factor antiserum

Cited by 38 publications

References 9 publications

Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia

Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia

Effects of elevated levels of nerve growth factor on the septohippocampal system in transgenic mice

NGF‐dependent and NGF‐independent recovery of sympathetic function after chemical sympathectomy with 6‐hydroxydopamine

Contact Info

Product

Resources

About