Catecholamines in murine bone marrow derived mast cells

Freeman, Jessica G.; Ryan, John; Shelburne, Christopher P.; Bailey, Daniel; Bouton, L.Andrew; Narasimhachari, N.; Domen, Jos; Siméon, N.; Couderc, François; Stewart, Jesse C.

doi:10.1016/s0165-5728(01)00384-8

Cited by 54 publications

(29 citation statements)

References 40 publications

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“…Shortly thereafter, parallel experiments identified dopamine and norepinephrine in human PBMCs (15,16). In line with these findings, additional studies confirmed the presence of catecholamines in various other cells, including murine bone marrow derived mast cells (17), rodent macrophages and neutrophils (11,18), and in a macrophage cell line (19). Surprisingly high levels of the epinephrine-synthesizing enzyme, phenylethanolamine-N-methyl transferase (PNMT), were found in the thymus of young mice, which were comparable to levels in the brainstem ( Figure 1A; 20).…”

Section: Immune Cells-a New Diffusely Expressed Adrenergic Organmentioning

confidence: 52%

“…Therefore, it seems likely that catecholamines use intracellular oxidative mechanisms to exert autoregulatory functions on immune cells. Even more importantly, a catecholamine-specific transporter has been described on nuclear membranes of lymphocytes, which actively transports catecholamines from the cytoplasm into the cell nucleus where catecholamines interact with nuclear receptors such as steroid receptors (16,68), influence transcription processes via interaction with nuclear factor (NF-)κB, and modulate apoptosis (69) by facilitating the expression of proto-oncogene Bax while attenuating Bcl-2 expression (16,17). It is noteworthy that the mitochondria-associated MAO and the cytosolic COMT fail to enter the nucleus, posing the important but so far unanswered question of how and by what mechanism intranuclear actions of catecholamines are terminated.…”

Section: Modulation Of Immune/inflammatory Cell Functions By Catecholmentioning

confidence: 99%

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Catecholamines—Crafty Weapons in the Inflammatory Arsenal of Immune/Inflammatory Cells or Opening Pandora’s Box?

Flierl

Rittirsch

Huber‐Lang

et al. 2008

Mol Med

165

114

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It is well established that catecholamines (CAs), which regulate immune and inflammatory responses, derive from the adrenal medulla and from presynaptic neurons. Recent studies reveal that T cells also can synthesize and release catecholamines which then can regulate T cell function. We have shown recently that macrophages and neutrophils, when stimulated, can generate and release catecholamines de novo which, then, in an autocrine/paracrine manner, regulate mediator release from these phagocytes via engagement of adrenergic receptors. Moreover, regulation of catecholamine-generating enzymes as well as degrading enzymes clearly alter the inflammatory response of phagocytes, such as the release of proinflammatory mediators. Accordingly, it appears that phagocytic cells and lymphocytes may represent a major, newly recognized source of catecholamines that regulate inflammatory responses.

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Section: Immune Cells-a New Diffusely Expressed Adrenergic Organmentioning

confidence: 52%

Section: Modulation Of Immune/inflammatory Cell Functions By Catecholmentioning

confidence: 99%

Catecholamines—Crafty Weapons in the Inflammatory Arsenal of Immune/Inflammatory Cells or Opening Pandora’s Box?

Flierl

Rittirsch

Huber‐Lang

et al. 2008

Mol Med

165

114

View full text Add to dashboard Cite

show abstract

“…47). Three of these genes (bcl-2, bcl-x, and bax) have been shown to regulate mast cell apoptosis (45,46,48). Thus, ChIP was performed on chromatin from IL-4-stimulated mast cells using the STAT6 Ab M200 and primers specific for the apoptosis genes bcl-2, bcl-x, and bax.…”

Section: Stat6␤ Binds To the Mast Cell Il-4 Promoter In Vivomentioning

confidence: 99%

IL-4 Induces the Proteolytic Processing of Mast Cell STAT6

Sherman

Powell

Brown

2002

The Journal of Immunology

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IL-4 is a potent, pleiotropic cytokine that, in general, directs cellular activation, differentiation, and rescue from apoptosis. However, in mast cells, IL-4 induces the down-regulation of activation receptors and promotes cell death. Mast cells have been shown to transduce IL-4 signals through a unique C-terminally truncated isoform of STAT6. In this study, we examine the mechanism through which STAT6 is processed to generate this isoform. We demonstrate that STAT6 processing in mast cells is initiated by IL-4-induced phosphorylation and nuclear translocation of full-length STAT6 and subsequent cleavage by a nuclear serine-family protease. The location of the protease in the nucleus ensures that the truncated STAT6 has preferential access to bind DNA. IL-4-responsive target genes in mast cells are identified by chromatin immunoprecipitation of STAT6, including the IL-4 gene itself. These results suggest a molecular explanation for the suppressive effects of IL-4 on STAT6-regulated genes in mast cells.

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“…Produkowane w nich neurotransmitery, takie jak aminy katecholowe, adrenalina czy noradrenalina, uwalniane z limfocytów [5,6], komórek tucznych [7], neutrofilów lub makrofagów [8], mogą wywierać znaczny wpływ na aktywność neuronów.…”

Section: Role Of Physiologic Issues In Future Therapy Of Rheumatoid Aunclassified

Role of physiologic issues in future therapy of rheumatoid arthritis I. Chronic inflammation toward action of parasympathetic system

Gajewski¹,

Rzodkiewicz²,

Maśliński³

et al. 2013

Reumatologia

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Odkrycie wspólnego biochemicznego języka, jakim komunikują się między sobą układ nerwowy i odpornościowy, uznawane jest za jedno z największych odkryć współczesnej biologii. Wykazanie, że samo zakłócenie równowagi w poziomie cytokin, wydzielanych przez komórki biorące udział w zapaleniu, może spowodować wystąpienie objawów chorobowych rzuca nowe światło na genezę przewlekłych zapaleń. <br /> W niniejszej publikacji przeanalizowano wstępnie znaczenie układu autonomicznego w regulacji procesów zapalnych oraz możliwą rolę nerwu błędnego w rozwoju reumatoidalnego zapalenia stawów.

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Catecholamines in murine bone marrow derived mast cells

Cited by 54 publications

References 40 publications

Catecholamines—Crafty Weapons in the Inflammatory Arsenal of Immune/Inflammatory Cells or Opening Pandora’s Box?

Catecholamines—Crafty Weapons in the Inflammatory Arsenal of Immune/Inflammatory Cells or Opening Pandora’s Box?

IL-4 Induces the Proteolytic Processing of Mast Cell STAT6

Role of physiologic issues in future therapy of rheumatoid arthritis I. Chronic inflammation toward action of parasympathetic system

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