Catecholaminergic innervation of the septum in the frog: A combined immunohistochemical and tract‐tracing study

Sánchez-Camacho, Cristina; Peña, Juan José; González, Agustı́n

doi:10.1002/cne.10500

Cited by 33 publications

(33 citation statements)

References 67 publications

(72 reference statements)

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“…They were restricted to tegmental nuclei and the caudal extent of the posterior tubercle (discussed below) in the mesencephalon and the laterodorsal tegmental and raphe nuclei in the rostral rhombencephalon. The laterodorsal tegmental nucleus has been demonstrated to be an important cholinergic and nitrergic center in anurans and, therefore, may provide this type of input to the MeA Marín et al, 1997d;López and Gonzá lez, 2002), as it most likely does to other limbic structures such as the medial pallium and the septum (Sá nchez-Camacho et al, 2003). Of note, anterograde tracer injections that involved the laterodorsal tegmental nucleus in R. perezi clearly labeled fibers and terminals in the MeA (Marín et al, 1997a).…”

Section: Mea Connections In Anuransmentioning

confidence: 95%

Hodological characterization of the medial amygdala in anuran amphibians

Moreno

González

2003

J of Comparative Neurology

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132

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Early studies in anuran amphibians defined the amygdala as a single unit that only later could be subdivided into medial and lateral parts with the achievement of sensitive immunohistochemical and tracing techniques. However, the terminology used was often misleading when comparing with "homologous" amygdaloid nuclei in amniotes. Recently, the basal telencephalon of anurans has been demonstrated to be more complex than previously thought, and distinct amygdaloid nuclei were proposed on the basis of immunohistochemistry. Moreover, developmental data are increasing that support this notion. In the present study, we analyzed the patterns of afferent and efferent connections of the medial amygdala (MeA; formerly amygdala pars lateralis), considered as the main target of the vomeronasal information from the accessory olfactory bulb, as in other vertebrates. By means of axonal transport of dextran amines, the afferent and efferent connections of the MeA were traced in Rana perezi and Xenopus laevis under in vivo and in vitro conditions. Largely similar results were found in both species. The results showed abundant intratelencephalic and extratelencephalic connections that were readily comparable to those of other tetrapods. Most of these connections were reciprocal and, in particular, the strong relation of the MeA with the hypothalamus, via the stria terminalis, was demonstrated. Immunohistochemical techniques showed staining patterns that revealed abundant peptidergic afferents to the MeA, as well as minor inputs containing other neurotransmitters such as catecholamines. Double-labeling experiments demonstrated that the peptidergic fibers that reach the MeA originate in the ventral hypothalamus, whereas the catecholaminergic innervation of the MeA arises in the caudal extent of the posterior tubercle. Taken together, the results about connectivity in our study support the comparison of the MeA in anurans with its counterparts (and similarly named) amygdaloid nuclei in amniotes. Most of the hodological features of the medial amygdala seem to be shared by those tetrapods with well-developed vomeronasal systems.

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Section: Mea Connections In Anuransmentioning

confidence: 95%

Hodological characterization of the medial amygdala in anuran amphibians

Moreno

González

2003

J of Comparative Neurology

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132

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“…This region almost totally lacks CBir or CRir cells or fibers, as was also observed in the lateral septal region of urodeles [Morona and González, 2008]. Differently, abundant septal CRir and CBir cell populations in anurans distribute differently within distinct nuclei [Sánchez-Camacho et al, 2003Endepols et al, 2006]. Interestingly, the caudally located and shrunken septal region of Dermophis would correspond with the medial septal nucleus which contains, in addition to the CRir cell population demonstrated in the present study, GnRH immunoreactive cells and cholinergic and nitrergic neurons, as in anurans and urodeles [Marín et al, 1997;Rastogi et al, 1998;González et al, 2002a, b].…”

Section: Septummentioning

confidence: 96%

Localization of Calbindin-D28k and Calretinin in the Brain of Dermophis Mexicanus (Amphibia: Gymnophiona) and Its Bearing on the Interpretation of Newly Recognized Neuroanatomical Regions

Morona¹,

López²,

González³

2011

Brain Behav Evol

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The analysis of the distribution of the calbindin-D28k and calretinin immunoreactive (CBir and CRir) systems recently described in the brain of anuran and urodele amphibians was very useful for the interpretation of many otherwise indistinct brain regions and cell masses. In the present study we have followed a similar approach to investigate the distribution of CBir and CRir cell bodies and fibers in the brain of Dermophis mexicanus, a member of the much neglected third amphibian order of gymnophionans. The pattern of distribution obtained showed particular characteristics in Dermophis, such as the existence of abundant CRir elements in the olfactory bulbs and CBir and CRir cell populations in pallial areas. The distinct distribution of the two proteins allowed the tentative identification of currently described subregions, mainly in the amygdaloid complex and hypothalamic areas. The analysis of the diencephalon and brainstem distribution framed in the neuromeric model highlighted common traits with other amphibians but also specific features. Therefore, the immunohistochemical detection of calcium-binding proteins has served to discern cell populations and has helped to demonstrate neuronal heterogeneity. However, it should be pointed out that a straightforward comparison based only on the presence of these proteins should not be made due to the great variability observed in well-established homologous regions in the brain of different vertebrates, as evidenced within the class Amphibia.

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“…The amphibian LS is located medial to the lateral ventricles and has been identified by neurochemical means where cholinergic neurons are abundant in this region and sparse in other regions of the telencephalon (Marin et al, 1997b;Sánchez-Camacho et al, 2003). Furthermore, there are TH-immunoreactive fiber nests in this region , a feature that is conserved across vertebrates.…”

Section: Amphibiansmentioning

confidence: 99%

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

O’Connell

Hofmann

2011

J of Comparative Neurology

851

879

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All animals evaluate the salience of external stimuli and integrate them with internal physiological information into adaptive behavior. Natural and sexual selection impinge on these processes, yet our understanding of behavioral decision-making mechanisms and their evolution is still very limited. Insights from mammals indicate that two neural circuits are of crucial importance in this context: the social behavior network and the mesolimbic reward system. Here we review evidence from neurochemical, tract-tracing, developmental, and functional lesion/stimulation studies that delineates homology relationships for most of the nodes of these two circuits across the five major vertebrate lineages: mammals, birds, reptiles, amphibians, and teleost fish. We provide for the first time a comprehensive comparative analysis of the two neural circuits and conclude that they were already present in early vertebrates. We also propose that these circuits form a larger social decision-making (SDM) network that regulates adaptive behavior. Our synthesis thus provides an important foundation for understanding the evolution of the neural mechanisms underlying reward processing and behavioral regulation. J. Comp. Neurol. 519:3599-3639, 2011. INDEXING TERMS: social behavior; comparative neuroanatomy; amphibian; reptile; bird; teleost; reward system; social behavior network; limbic system; neural circuitsThroughout their lives, all animals constantly face situations that provide either challenges (e.g., aggression, predation) or opportunities (e.g., reproduction, foraging, habitat selection) (for a detailed review, see O'Connell and Hofmann, 2011). In all cases, environmental cues are processed by sensory systems into a meaningful biological signal while internal physiological cues (e.g., condition, maturity) and prior experience are integrated at the same time. This process usually results in behavioral actions that are adaptive, i.e., beneficial to the animal. To accomplish this, an animal's nervous system must evaluate the salience of a stimulus and elicit a context-appropriate behavioral response. Despite tremendous progress in understanding the ecology and evolution of social behavior (Lorenz, 1952;Tinbergen, 1963;Lehrman, 1965;von Frisch, 1967;Krebs and Davies, 1993;Stephens, 2008), it is less understood where in the brain these decisions (e.g., about mate choice or territory defense) are made and how these brain circuits have arisen over the course of vertebrate evolution.Recent research has begun to decipher the neural basis of social decision-making. In mammals in particular, the neural circuits that evaluate stimulus salience and/or regulate social behavior have been uncovered to some degree: the mesolimbic reward system and social behavior network (Fig. 1). It is becoming increasingly clear that the reward system (including but not limited to the midbrain dopaminergic system) is the neural circuit where the salience of an external stimulus is evaluated (Deco and Rolls, 2005;Wickens et al., 2007), as appetitive beh...

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Catecholaminergic innervation of the septum in the frog: A combined immunohistochemical and tract‐tracing study

Cited by 33 publications

References 67 publications

Hodological characterization of the medial amygdala in anuran amphibians

Hodological characterization of the medial amygdala in anuran amphibians

Localization of Calbindin-D28k and Calretinin in the Brain of Dermophis Mexicanus (Amphibia: Gymnophiona) and Its Bearing on the Interpretation of Newly Recognized Neuroanatomical Regions

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

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