Catecholaminergic Innervation of the Human Dura Mater Involved in Headache

Cavallotti, Daniela; Artico, Marco; Santis, Stefano De; Iannetti, Gian Domenico; Cavallotti, Carlo

doi:10.1046/j.1526-4610.1998.3805352.x

Cited by 16 publications

(14 citation statements)

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“…Using fluorescence techniques, Cavalloti et al (2) found that the cranial dura mater contains extensive sympathetic innervation. This finding is based on the principle that exposure of the dural mater to formaldehyde vapors causes catecholaminergic fibers to fluoresce.…”

Section: Sympathetic Innervation Of the Cranial Duramentioning

confidence: 99%

“…Unfortunately, the specific types of catecholaminergic fibers have not been elucidated (6). Cavallotti et al (2) concluded that all sympathetic fibers present in the cranial dura mater originate from the superior cervical ganglion, hypothesizing that the vasoconstrictor role of such sympathetic fibers may be implicated in the pathology of headache (2). Keller et al (7) confirmed that sympathetic fibers innervating the superior sagittal sinus of the rat and other areas of the supratentorial dura mater originated from the superior cervical ganglion.…”

Section: Sympathetic Innervation Of the Cranial Duramentioning

confidence: 99%

“…Some studies have focused on applied anatomy of the region. These include microanatomy, endoscopic anatomy, and sectional anatomy (2,5,14). But residents and other medical staff are still not familiar with the anatomic features of the region.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Innervation of the Cranial Dura Mater: Neurosurgical Case Correlates and a Review of the Literature

Kemp¹,

Tubbs²,

Cohen-Gadol³

2012

World Neurosurgery

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Section: Sympathetic Innervation Of the Cranial Duramentioning

confidence: 99%

Section: Sympathetic Innervation Of the Cranial Duramentioning

confidence: 99%

See 1 more Smart Citation

The Innervation of the Cranial Dura Mater: Neurosurgical Case Correlates and a Review of the Literature

Kemp¹,

Tubbs²,

Cohen-Gadol³

2012

World Neurosurgery

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“…When the vasoconstrictor activity of D2 receptors is blocked, blood flow increases. In the light of the results of previous studies, 13,19 the presence of D1 and D2 receptors in the wall of the rat dura mater vessels appears significant.…”

Section: Discussionmentioning

confidence: 78%

Dopaminergic Receptors in Rat Dura Mater: Pharmacological Characteristics

Cavallotti¹,

Frati

Cavallotti

et al. 2004

Clin Exp Pharma Physio

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1. The location and distribution of dopaminergic receptors in rat dura mater was studied by examining several dural zones (vascular, perivascular, intervascular) in different cranial and spinal regions. 2. The pharmacological characteristics and anatomical distribution of dopamine D1- and D2-like receptors sites were investigated using combined pharmacological techniques and immunofluorescent microscopy. 3. Samples of rat dura mater were obtained from 10 adult Wistar rats. On frozen slices, dopaminergic D1 and D2 receptors were stained immunohistochemically using monoclonal antibodies. 4. Inhibition studies were performed using fluorescent and non-fluorescent agonists or antagonists to define the pharmacological specificity of the immunostaining. 5. The greater sensitivity to displacement by amisulpride, bromocryptine, domperidone, haloperidol, raclopride and l-sulpiride than to displacement by N-propyl-nor-apomorphine, quinpirole and clozapine suggests that the immunofluorescent sites observed in these experiments are likely to belong to the dopamine D2 receptor subtype. 6. Our observations provide evidence of the presence of D1 and D2 receptors in the wall of meningeal vessels. The dopaminergic receptors are located in the adventitia, media and intima of dural arteries. Furthermore, the density of receptors is higher in close proximity to arteries and decreases passing from the vascular to the perivascular and intervascular zones. 7. In the rat dura mater, dopamine regulates the meningeal blood vessels and, through this action, dopamine and its receptors can play an important role in the pathogenesis of cephalalgia.

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“…2) [32]. Catecholaminergic fibers from the dura also originate from the superior cervical ganglion of the sympathetic chain [33]. Although the innervation of the dura cannot readily be interrupted with extracranial nerve blocks, knowledge of these pathways is still important for relieving pain during awake intracranial surgery.…”

Section: Pain and Intracranial Surgerymentioning

confidence: 99%

The Perioperative Management of Pain from Intracranial Surgery

Gottschalk

Yaster

2008

Neurocrit Care

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Analgesic therapy following intracranial procedures remains a source of concern and controversy. Although opioids are the mainstay of the "balanced" general anesthetic techniques frequently used during intracranial procedures, neurosurgeons and others have been reluctant to administer opioid analgesics to patients following such procedures. This practice is supported by the concern that the sedation and miosis associated with opioid administration could mask the early signs of intracranial catastrophe, or even exacerbate it through decreased ventilatory drive, elevated arterial carbon dioxide levels, and increased cerebral blood flow. This reluctance to use opioids following intracranial surgery is enabled by decades of training and anecdote emphasizing that pain is minimal following these procedures. However, recent data suggests otherwise, and raises the question of how to provide safe and effective analgesia for these patients. Here, this data is reviewed along with the relevant pain pathways, analgesic drugs and techniques, and the available data on their use following intracranial surgery. Although pain following intracranial surgery appears to be more intense than initially believed, it is readily treated safely and effectively with techniques that have proven useful following other types of surgery, including patient-controlled administration of opioids. The use of multimodal analgesic therapy is emphasized not only for its effectiveness, but to reduce dosages and, therefore, side effects, primarily of the opioids, that could be of legitimate concern to physicians and affect the comfort of their patients.

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Catecholaminergic Innervation of the Human Dura Mater Involved in Headache

Cited by 16 publications

References 0 publications

The Innervation of the Cranial Dura Mater: Neurosurgical Case Correlates and a Review of the Literature

The Innervation of the Cranial Dura Mater: Neurosurgical Case Correlates and a Review of the Literature

Dopaminergic Receptors in Rat Dura Mater: Pharmacological Characteristics

The Perioperative Management of Pain from Intracranial Surgery

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