Catecholaminergic hippocampal activation is necessary for object recognition memory persistence induced by one-single physical exercise session

Vargas, Liane S.; Lima, Karine Ramires; Ramborger, Bruna Piaia; Roehrs, Rafael; Izquierdo, Iván; Mello‐Carpes, Pâmela Billig

doi:10.1016/j.bbr.2019.112356

Cited by 11 publications

(12 citation statements)

References 38 publications

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“…Moreover, our data are in line with a previous study showing that hippocampal norepinephrine is necessary for object recognition memory consolidation (Mello-Carpes et al, 2016). In addition, a recent study in rats also shows that memory persistence can be enhanced with physical exercise, which is completely blocked by an intra-hippocampal infusion of the D 1/5 R antagonist SCH23390, indicating that memory persistence is a dopamine dependent process (Vargas et al, 2020).…”

Section: Discussionsupporting

confidence: 92%

The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory

Titulaer

Björkholm

Feltmann

et al. 2021

Front. Behav. Neurosci.

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Dopaminergic neurons originating from the ventral tegmental area (VTA) and the locus coeruleus are innervating the ventral hippocampus and are thought to play an essential role for efficient cognitive function. Moreover, these VTA projections are hypothesized to be part of a functional loop, in which dopamine regulates memory storage. It is hypothesized that when a novel stimulus is encountered and recognized as novel, increased dopamine activity in the hippocampus induces long-term potentiation and long-term storage of memories. We here demonstrate the importance of increased release of dopamine and norepinephrinein the rat ventral hippocampus on recognition memory, using microdialysis combined to a modified novel object recognition test. We found that presenting rats to a novel object significantly increased dopamine and norepinephrine output in the ventral hippocampus. Two hours after introducing the first object, a second object (either novel or familiar) was placed in the same position as the first object. Presenting the animals to a second novel object significantly increased dopamine and norepinephrine release in the ventral hippocampus, compared to a familiar object. In conclusion, this study suggests that dopamine and norepinephrine output in the ventral hippocampus has a crucial role in recognition memory and signals novelty.

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Section: Discussionsupporting

confidence: 92%

The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory

Titulaer

Björkholm

Feltmann

et al. 2021

Front. Behav. Neurosci.

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“…Studies demonstrated that 5 min exploring a new environment increase immediately dopamine levels in the hippocampus (Lima et al, 2019; Menezes et al, 2015). Furthermore, studies that applied pharmacological dopamine stimulators in the same time window revealed NOR memory persistence after that (Lima et al, 2021; Neves et al, 2020; Vargas et al, 2020). So we choose to test the effects of novelty exposure immediately after training on memory persistence, which demonstrated a similar response to the direct dopaminergic stimulation in the hippocampus, depending on the D1Rs and PKA activation.…”

Section: Discussionmentioning

confidence: 99%

“…The drug concentrations were as follows: SKF 38393, 12.5 μg/μl; SCH 23390, 1 μg/μl; Rp‐cAMP, .5 μg/μl; Sp‐cAMP, .5 μg/μl; Gö 6976, 1.7 ng/μl; and PMA, .5 μg/μl. The concentrations and volumes were based on previous studies showing each compound's effect on learning and behavioural performance (Furini et al, 2014; Menezes et al, 2015; Neves et al, 2020; Vargas et al, 2020).…”

Section: Methodsmentioning

confidence: 99%

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Novelty promotes recognition memory persistence by D1 dopamine receptor and protein kinase A signalling in rat hippocampus

Lima

Rosa

Picua

et al. 2021

Eur J of Neuroscience

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Strategies for improving memory are increasingly studied, and exposure to a novel experience can be an efficient neuromodulator. Novelty effects on memory depend on D1‐family dopamine receptors (D1Rs) activation. Here, we evaluated the novelty effect on memory persistence of Wistar rats and investigated the contribution of D1Rs and their signalling pathways by protein kinase A (PKA) and C (PKC). Animals with infusion cannulae inserted into the CA1 hippocampus area were trained on the novel object recognition (NOR) task, which involved exploring two different objects. After training, some rats received intrahippocampal infusions of vehicle or D1Rs agonist; others explored a novel environment for 5 min and were infused with a variety of drugs targeting D1Rs and their signalling pathways. We demonstrated that pharmacological stimulation of D1Rs or novelty exposure promoted NOR memory persistence for 14 days and that the novelty effect depended on D1Rs activation. To determine if the D1 and D5 receptor subtypes were necessary for the impact of novelty exposure on memory, we blocked or stimulated PKA or PKC—protein kinases activated mainly by D1 and D5, respectively. Only PKA inhibition impaired the effect of novelty on memory persistence. After novelty and D1Rs blocking, PKA but not PKC stimulation maintained the memory persistence effect. Thus, we concluded that novelty promoted memory persistence by a mechanism‐dependent on activating hippocampal D1Rs and PKA pathway.

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“…Previous data from the literature showed that long intervals of time lead to the deterioration of LTM for objects and that the hippocampus is required for object memory encoding after long intertrial intervals [ 73 ] and persistence of object recognition memory [ 74 ]. Thus, we hypothesized that treatment with a cognitive enhancer could result in the maintenance of LTM for objects over time.…”

Section: Methodsmentioning

confidence: 99%

BDNF as a Putative Target for Standardized Extract of Ginkgo biloba-Induced Persistence of Object Recognition Memory

et al. 2021

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Despite considerable progress on the study of the effect of standardized extract of Gingko biloba (EGb) on memory processes, our understanding of its role in the persistence of long-term memory (LTM) and the molecular mechanism underlying its effect, particularly episodic-like memory, is limited. We here investigated the effects of EGb on the long-term retention of recognition memory and its persistence and BDNF expression levels in the dorsal hippocampal formation (DHF). Adult male Wistar rats (n = 10/group) were handled for 10 min/5 day. On day 6, the animals were treated with vehicle or 0.4 mg/kg diazepam (control groups) or with EGb (250, 500 or 100 mg/kg) 30 min before the training session (TR1), in which the animals were exposed to two sample objects. On day 7, all rats underwent a second training session (TR2) as described in the TR1 but without drug treatment. Object recognition memory (ORM) was evaluated on day 8 (retention test, T1) and day 9 (persistence test, T2). At the end of T1or T2, animals were decapitated, and DHF samples were frozen at −80 °C for analyses of the differential expression of BDNF by Western blotting. EGb-treated groups spent more time exploring the novel object in T2 and showed the highest recognition index (RI) values during the T1 and T2, which was associated with upregulation of BDNF expression in the DHF in a dose-and session-dependent manner. Our data reveal, for the first time, that EGb treatment before acquisition of ORM promotes persistence of LTM by BDNF differential expression.

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Catecholaminergic hippocampal activation is necessary for object recognition memory persistence induced by one-single physical exercise session

Cited by 11 publications

References 38 publications

The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory

The Importance of Ventral Hippocampal Dopamine and Norepinephrine in Recognition Memory

Novelty promotes recognition memory persistence by D1 dopamine receptor and protein kinase A signalling in rat hippocampus

BDNF as a Putative Target for Standardized Extract of Ginkgo biloba-Induced Persistence of Object Recognition Memory

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