Catecholamine Response to the Clinical Use of Alpha Adrenergic Receptor Blocking Agents

Risbo, A.; Hagelsten, J. O.

doi:10.1111/j.1399-6576.1983.tb01908.x

Cited by 23 publications

(7 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The neuroleptics used may affect plasma NE and 3‐MT levels. Previous clinical study has indicated that haloperidol (5‐10 mg/day or 10‐20 mg/day) decreased plasma NE levels in schizophrenics over a 6‐week course of treatment,29 and that infusion of chlorpromazine (25 mg) decreased plasma NE levels 30. However, a number of studies have found that the neuroleptics have no effect on peripheral NE levels.…”

Section: Discussionmentioning

confidence: 99%

“…Previous clinical study has indicated that haloperidol (5-10 mg/day or 10-20 mg/day) decreased plasma NE levels in schizophrenics over a 6-week course of treatment, 29 and that infusion of chlorpromazine (25 mg) decreased plasma NE levels. 30 However, a number of studies have found that the neuroleptics have no effect on peripheral NE levels. Haloperidol (4 mg/day) for 5 weeks, 31 or administration of haloperidol (4-8 mg/ day) or thioridazine (150-400 mg/day) for at least 10 days, 32 has no significant effect on peripheral noradrenergic activity.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Factors for Susceptibility to Episode Recurrence in Spontaneous Recurrence of Methamphetamine Psychosis

Yui

Ikemoto

Gotō

2002

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

The relation between increased sensitivity to stress associated with noradrenergic hyperactivity and dopaminergic changes, and susceptibility to subsequent spontaneous recurrences of methamphetamine (MAP) psychosis (flashbacks) was examined. Plasma monoamine metabolite levels were assayed in 19 flashbackers, of whom 10 experienced a single flashback and 9 exhibited subsequent flashbacks, 18 nonflashbackers with a history of MAP psychosis, 9 subjects with persistent MAP psychosis, and 22 MAP user and 10 nonuser controls. All flashbackers had undergone frightening stressful experiences during previous MAP use. They exhibited flashbacks in response to mild psychosocial stressors. There was no significant difference in the number of stressful experiences and having mild psychosocial stressors between the two flashbacker subgroups. Plasma norepinephrine (NE) levels increased with a small increase in plasma levels of 3‐methoxytyramine (3‐MT), an index of dopamine release, during flashbacks in the 19 flashbackers. Of the 19 flashbackers, the 9 with subsequent episodes had markedly increased NE levels and slightly increased 3‐MT levels during flashbacks, while the 10 with a single episode displayed small increases in NE and 3‐MT levels during flashbacks. The 9 flashbackers with subsequent episodes had a longer duration of imprisonment than the 10 flashbackers with a single episode. Thus, robust noradrenergic hyperactivity with slightly increased DA release in response to mild stress may predict subsequent flashbacks. Long‐term exposure to distressing situations appears to contribute to susceptibility to subsequent flashbacks.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Factors for Susceptibility to Episode Recurrence in Spontaneous Recurrence of Methamphetamine Psychosis

Yui

Ikemoto

Gotō

2002

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

show abstract

“…Clinical studies have shown that haloperidol 22 or chlorpromazine 23 decreased plasma NE levels, and that thioridazine 24 had no significant effect on peripheral noradrenergic activity. Preclinical studies have reported that haloperidol or chlorpromazine had no significant effects on brain 3-MT levels.…”

Section: Increased Sensitivity To Stress Associated With a Predominanmentioning

confidence: 99%

Neurobiological basis of relapse prediction in stimulant-induced psychosis and schizophrenia: the role of sensitization

et al. 1999

View full text Add to dashboard Cite

A number of consistent clinical observations provide direction for the hypothesis that pathological sensitization of neuronal systems may be an important factor for relapse or the onset of stimulant-induced psychosis (eg, methamphetamine or amphetamine psychosis, cocaine psychosis and phencyclidine psychosis) and schizophrenia. First, psychotic symptoms can be produced in normal subjects by stimulants. Secondly, a large portion of schizophrenic patients exhibit exacerbation of psychotic symptoms in response to stimulants at doses which would not be psychotogenic in normal subjects. Lastly, the ability of stress to precipitate the onset and relapse of schizophrenia is well documented. In this regard, acute responses to stimulants provide useful information for relapse prediction of schizophrenia and substance abuse. This paper addresses the nature and role of pathological sensitization in relapse of stimulant-and phencyclidine-induced psychosis and schizophrenia, and its relation to pathophysiology of schizophrenia.

show abstract

“…Treatment with haloperidol (4-8 mg / day) or thioridazine (150-400 mg / day) for at least 10 days has been reported to have no effect on peripheral noradrenergic activity (Tuck 1973). Infusion of chlorpromazine (25 mg) has been shown to decrease plasma NE levels (Risbo et al 1983). In the present study, both the 13 medicated and the 13 later-medicated subjects with flashbacks had significantly higher NE levels than the user and non-user controls.…”

Section: Discussionmentioning

confidence: 98%

Precipitating factors in spontaneous recurrence of methamphetamine psychosis

Yui

Ishiguro

Gotō³

et al. 1997

Psychopharmacology

View full text Add to dashboard Cite

This paper examines noradrenergic hyperactivity in response to stress in the development of spontaneous recurrences of methamphetamine (MAP) psychosis, a phenomenon known as flashbacks, in studies of psychedelic drug use. We studied predictors of flashbacks in 36 subjects with flashbacks, along with 80 subjects with a history of MAP psychosis who did not experience flashbacks. Plasma monoamine metabolite levels were assayed in 26 of the 36 subjects with flashbacks, 16 of the 80 subjects without flashbacks, nine subjects with persistent MAP psychosis, and 28 normal controls. None of the 28 controls became psychotic. A square root transformation was applied to all monoaminergic values, resulting in data nearly normally distributed. The subjects with flashbacks had been exposed to stressful events or threatening paranoid-hallucinatory states or both during previous MAP use. Most flashbacks occurred under conditions that provoked a mild fear of other people. Plasma norepinephrine levels were markedly increased during flashbacks. Thus, stressful experiences together with MAP use may have induced noradrenergic hyperreactivity to a mild stress, which in turn may elicit memories of MAP psychosis associated with stressful experiences. A mild fear of other people precipitated the flashbacks, including markedly increased noradrenergic activity. The results of this study suggest that noradrenergic hyperreactivity to a mild stress is a precipitating factor in spontaneous recurrences of MAP psychosis.

show abstract

Catecholamine Response to the Clinical Use of Alpha Adrenergic Receptor Blocking Agents

Cited by 23 publications

References 6 publications

Factors for Susceptibility to Episode Recurrence in Spontaneous Recurrence of Methamphetamine Psychosis

Factors for Susceptibility to Episode Recurrence in Spontaneous Recurrence of Methamphetamine Psychosis

Neurobiological basis of relapse prediction in stimulant-induced psychosis and schizophrenia: the role of sensitization

Precipitating factors in spontaneous recurrence of methamphetamine psychosis

Contact Info

Product

Resources

About