Catecholamine Metabolism in Anorexia Nervosa

Halmi, Katherine A.; Dekirmenjian, Harry; Davis, John M.; Casper, Regina C.; Goldberg, Solomon C.

doi:10.1001/archpsyc.1978.01770280068007

Cited by 110 publications

(29 citation statements)

References 19 publications

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“…Several investigators have reported reduced urinary excretion of MHPG in AN patients (45)(46)(47)(48). In our study no significant group effect was observed, although urinary MHPG excretion in the patient group was significantly lower than in the lean control group ( Table 2).…”

Section: Discussioncontrasting

confidence: 53%

Biogenic amines in anorexia nervosa: circadian rhythm in urinary excretion and influence of posture and physical task load on plasma catecholamines.

Binsbergen¹,

Odink²,

Beek³

et al. 1991

Psychosomatic Medicine

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To investigate the sympathetic response in anorexia nervosa (AN) patients to stimuli occurring in normal life, biogenic amines were studied in 10 female outpatients. As control groups 10 lean and 10 normal weight healthy female subjects were included. It was hypothesized that the lean control group would have intermediate values between the AN patients and the normal weight controls. The AN patients and the lean controls had a mean underweight of 33.1% and 13.7%, respectively. For the excretion in 24-hr urine, differences among the groups were observed for several compounds, unexpectedly the values being lowest for the patients and highest for the lean controls. Furthermore, the lean controls had a higher excretion of a number of compounds in diurnal than in nocturnal urine, whereas this effect was absent or reversed for the AN patients and intermediate for the normal weight controls. Plasma norepinephrine was highest in the patients and lowest in the lean controls. The catecholamine response to postural changes and physical exercise did not differ among the groups. The results obtained indicate neither a (linear) relationship between underweight and the metabolism of biogenic amines nor a disturbed response to sympathetic stimulation in AN, but suggest an altered metabolism of biogenic amines in patients suffering from AN.

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Section: Discussioncontrasting

confidence: 53%

Biogenic amines in anorexia nervosa: circadian rhythm in urinary excretion and influence of posture and physical task load on plasma catecholamines.

Binsbergen¹,

Odink²,

Beek³

et al. 1991

Psychosomatic Medicine

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“…A recent study by three of our investigators has shown that urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) was significantly lower in acutely ill anorexic patients than in female controls (Halmi et al 1978). An increase in urinary MHPG was significantly correlated with a decrease in depression ratings after weight gain.…”

Section: Introductionmentioning

confidence: 98%

Depression in anorexia nervosa

et al. 1982

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SYNOPSIS In three collaborating institutions 105 hospitalized female anorexia nervosa patients were assessed for depressive symptomatology periodically during treatment. As a whole, patients were mildly to moderately depressed, being as depressed as anxious neurotics and less depressed than depressed neurotics. The more depressed patients showed a variety of characteristics, many of which have previously been shown to be indicators of poor prognosis. Over the course of treatment patients became less depressed. Weight gain was correlated with a decrease in depression.

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“…However, recent work has focused on the identification of a central nervous system dysfunction in eating disorders and has demonstrated abnormal findings in computed tomographic brain scans [1,2], positron emission tomography [3], neurotransmitter [4,5], and neuropeptide levels [6], and brain event-related potentials (ERPs) [7].…”

Section: Introductionmentioning

confidence: 99%

Prolonged P300 Latency in Eating Disorders

Otagaki

Tohoda²,

Osada³

et al. 1997

Neuropsychobiology

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This study investigated event-related potential (ERP) indices of information-processing in eating disorders. ERPs during an auditory two-tone discrimination task were recorded at midline at 3 sites in 28 anorexic patients, 12 low-weight bulimic patients (body mass index (BMI) under 17.5), 12 normal-weight bulimic patients (BMI over 17.5), and 40 control subjects. The P300 latency was significantly prolonged at all sites in both bulimic groups compared with that in controls, and at frontal and central electrode sites in anorexics. In contrast, the P300 amplitude did not differ between these groups at any site. The prolonged P300 latency in eating disorders suggests a task-related slowing of perceptual decisions that reflects their cognitive impairment.

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Catecholamine Metabolism in Anorexia Nervosa

Cited by 110 publications

References 19 publications

Biogenic amines in anorexia nervosa: circadian rhythm in urinary excretion and influence of posture and physical task load on plasma catecholamines.

Biogenic amines in anorexia nervosa: circadian rhythm in urinary excretion and influence of posture and physical task load on plasma catecholamines.

Depression in anorexia nervosa

Prolonged P300 Latency in Eating Disorders

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