Catechol-O-Methyltransferase Val158Met and brain-derived neurotrophic factor Val66Met gene polymorphisms in paraphilic sexual offenders

Cengiz, Müjgan; Cezayirli, Esma; Bayoğlu, Burcu; Aslıyüksek, Hızır; Kocabaşoğlu, Neşe

doi:10.4103/psychiatry.indianjpsychiatry_194_18

Cited by 2 publications

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References 35 publications

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“…Studies in local and abroad have shown that the changes of pain-related genes in the trigeminal ganglion are closely related to the occurrence and development of tooth movement pain [ 28 , 29 ]. COMT is mainly distributed in the postsynaptic neurons and glial cells of the nervous system [ 30 , 31 ], as well as in the peripheral tissues [ 32 ]. In addition, Nicholson et al found that the COMT gene expression level in the trigeminal ganglion will lead to corresponding changes in the behavioral response of pain in experimental animals [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Catechol-O-methyltransferase Regulating Orofacial Pain Induced by Tooth Movement

Zhou

Zhang

Chen

et al. 2021

BioMed Research International

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Objective. To explore the mechanism of catechol-O-methyltransferase (COMT) in tooth movement pain. Methods. The experimental groups were randomly allocated into the healthy control, sham operation, model, model+shCOMT experimental, model+shCOMT control, and model+COMT antagonist groups. A tooth movement pain model was established. The pain stimulation and behavior test were performed. The duration of grooming behavior was determined. The appropriate experimental force and duration for application were selected. COMT shRNA vector was constructed and packaged as adenovirus. The shCOMT adenovirus was injected into the left infraorbital foramen. Seven days later, the trigeminal ganglia of all treatment groups were obtained. The COMT and IL-17 expressions were detected by western blot. The appropriate COMT antagonist concentration was selected. The pathological results of each group were detected by HE staining. The tooth movement distance was determined. The COMT gene expression was detected by FISH. The COMT and IL-17 expressions in the right trigeminal ganglion tissue of each group were detected by western blot. Results. The 60 g force and 14-day duration required the lowest stimulus intensity, the duration of grooming behavior was the longest, and the effect on COMT and IL-17 was the most significant. In the model group, formation of digestive cavity was seen in the trigeminal ganglion tissue, with infiltration of inflammatory cells, upregulation of the COMT and IL-17 expressions, and significant increase in the tooth movement distance. Compared with the model group, the shCOMT experimental group and the COMT antagonist group significantly improved the trigeminal ganglion tissue injury, significantly decreased the tooth movement distance, and significantly inhibited the COMT and IL-17 expressions. Conclusion. The efficiency of tooth movement can be influenced by interfering the COMT-related gene expression. This proves that the COMT system can regulate the orthodontic tooth movement pain.

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