Catechol-O-methyltransferase gene and obsessive–compulsive symptoms in patients with recent-onset schizophrenia: Preliminary results

Zinkstok, Janneke; Nimwegen, Lonneke van; Amelsvoort, Thérèse van; Haan, Lieuwe de; Yusuf, Maryan Abdulkadir; Baas, Frank; Linszen, Don

doi:10.1016/j.psychres.2007.02.001

Cited by 22 publications

(12 citation statements)

References 45 publications

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“…We did not find any difference in YBOCS-severity scores between patients with different COMT Val158Met genotypes. To our knowledge, only one study that investigated the relationship between YBOCS severity score and the COMT Val158Met genotype found an association between the high activity genotype and increased YBOCS-severity scores in young males with recent-onset schizophrenia [Zinkstok et al, 2008]. We found a trend for lower scores on the somatic obsessions and sensory phenomena factor in females with the COMT Val158Met genotype.…”

Section: Discussionmentioning

confidence: 41%

The role of the COMT Val¹⁵⁸Met polymorphism in the phenotypic expression of obsessive‐compulsive disorder

Katerberg

Cath

Denys

et al. 2009

American J of Med Genetics Pt B

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Obsessive-Compulsive Disorder (OCD) is characterized by the presence of obsessions and compulsions, and shows considerable phenotypic variability. Family and twin studies have indicated a genetic component in the etiology of OCD, and the catechol-O-methyl transferase (COMT) gene is an important candidate gene for OCD. This study investigates the influence of the functional COMT Val158Met polymorphism on the phenotypic expression of OCD, using an item-level factor-analytic approach in a large sample. The COMT Val158Met variant was genotyped in 373 patients and 462 controls. It was tested whether there was an association between the COMT Val158Met polymorphism and OCD or dimensional phenotypes such as YBOCS severity score, age of onset of obsessive-compulsive symptoms and six symptom dimensions recently found in a large item-level factor-analytic study [Katerberg et al., submitted]. We further investigated possible sex-specific associations between the COMT Val158Met polymorphism and OCD or dimensional phenotypes. There was a trend for an association of the COMT 158Met allele with OCD in males, and an interaction between the COMT Val158Met genotype and sex on the somatic and sensory phenomena symptom dimension, with females showing lower scores. In conclusion, a dimensional approach seems fruitful in detecting genes of importance for OCD.

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Section: Discussionmentioning

confidence: 41%

The role of the COMT Val¹⁵⁸Met polymorphism in the phenotypic expression of obsessive‐compulsive disorder

Katerberg

Cath

Denys

et al. 2009

American J of Med Genetics Pt B

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“…Four studies were based on clinically anxious individuals and their family members, i.e., individuals with a high genetic risk and therefore “selected” for anxiety disorders (Alsobrook et al ., 2002; Hamilton et al ., 2002; Schindler et al ., 2000; Walitza et al ., 2008;). Ten studies were selected for a non-anxiety phenotype (i.e., exclusion criterion C; Barr et al, 1999; Birklein et al, 2008; Enoch et al ., 2003; Kolassa et al , 2010; Gothelf et al ., 2007a, 2007b; Light et al , 2007; Max et al ., 2006; Michaelovsky et al, 2008; Zinkstok et al, 2008). Thirteen studies did not include a measure of trait anxiety (Cavallini et al , 2000; Domschke et al ., 2004; Freitag et al ., 2006; Karayiorgiou et al ., 1997; O’Hara et al ., 1998; Pooley et al ., 2007; Poyurovsky et al ., 2005; Rothe et al ., 2006; Rotondo et al, 2002; Rujescu et al ., 2003; Samochowiecz et al ., 2004; Strug et al ., 2010; Woo et al ., 2002).…”

Section: Resultsmentioning

confidence: 99%

Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits

Lee

Prescott

2014

Psychiatric Genetics

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Objectives The main goals of this study were: (i) to examine genotypic association of the COMT val158met polymorphism with anxiety-related traits via a meta-analysis; (ii) to examine sex and ethnicity as moderators of the association, and (iii) to evaluate whether the association differed by particular anxiety traits. Methods Association studies of the COMT val18met polymorphism and anxiety traits were identified from the PubMed or PsycInfo databases, conference abstracts and listserv postings. Exclusion criteria were: (a) pediatric samples, (b) exclusively clinical samples, and (c) samples selected for a non-anxiety phenotype. Standardized mean differences in anxiety between genotypes were aggregated to produce mean effect sizes across all available samples, and for subgroups stratified by sex and ethnicity (Caucasians vs. Asians). Construct-specific analysis was conducted to evaluate the association of COMT with neuroticism, harm avoidance, and behavioral inhibition. Results Twenty seven eligible studies (N=15,979) with available data were identified. Overall findings indicate sex-specific and ethnic-specific effects: Val homozygotes had higher neuroticism than Met homozygotes in studies of Caucasian males ( trueES¯=0.13, 95%CI: 0.02 – 0.25, p = 0.03), and higher harm avoidance in studies of Asian males ( trueES¯=0.43, 95%CI: 0.14 – 0.72, p = 0.004). No significant associations were found in women and effect sizes were diminished when studies were aggregated across ethnicity or anxiety traits. Conclusions: This meta-analysis provides evidence for sex and ethnicity differences in the association of the COMT val158met polymorphism with anxiety traits. Our findings contribute to current knowledge on the relation between prefrontal dopaminergic transmission and anxiety.

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“…This principle is the introduction of “normal genes” into cells where “dysfunctional genes” have been identified. These target genes could include −141C Ins/Del DRD2 polymorphism (Kondo, Mihara, Suzuki, Yasui‐Furukori, & Kaneko, ; Suzuki et al, ), COMT Val(158)Met polymorphism (Zinkstok et al, ), CYP2D6 polymorphism (Dorado, Penas‐Lledo, & Llerena, ), and 5‐HTTLPR polymorphism of the 5′ promoter region of serotonin transporter gene (SLC6A4; Goldberg et al, ). However, there are many technical difficulties in application of gene therapy, and it is challenging to apply gene therapy to complex and psychiatric presentation, for example, schizophrenia with an anxiety disorder (Weatherall, ).…”

Section: Pharmacological Treatment Of Anxiety In Schizophreniamentioning

confidence: 99%

Current and potential pharmacological and psychosocial interventions for anxiety symptoms and disorders in patients with schizophrenia: structured review

Howells

Kingdon

Baldwin

2017

Human Psychopharmacology

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Catechol-O-methyltransferase gene and obsessive–compulsive symptoms in patients with recent-onset schizophrenia: Preliminary results

Cited by 22 publications

References 45 publications

The role of the COMT Val¹⁵⁸Met polymorphism in the phenotypic expression of obsessive‐compulsive disorder

The role of the COMT Val¹⁵⁸Met polymorphism in the phenotypic expression of obsessive‐compulsive disorder

Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits

Current and potential pharmacological and psychosocial interventions for anxiety symptoms and disorders in patients with schizophrenia: structured review

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Catechol-O-methyltransferase gene and obsessive–compulsive symptoms in patients with recent-onset schizophrenia: Preliminary results

Cited by 22 publications

References 45 publications

The role of the COMT Val158Met polymorphism in the phenotypic expression of obsessive‐compulsive disorder

The role of the COMT Val158Met polymorphism in the phenotypic expression of obsessive‐compulsive disorder

Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits

Current and potential pharmacological and psychosocial interventions for anxiety symptoms and disorders in patients with schizophrenia: structured review

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The role of the COMT Val¹⁵⁸Met polymorphism in the phenotypic expression of obsessive‐compulsive disorder

The role of the COMT Val¹⁵⁸Met polymorphism in the phenotypic expression of obsessive‐compulsive disorder