Catechins prevent monoclonal antibody fragmentation during production via fed‐batch culture of Chinese hamster ovary cells
Tsuyoshi Yamaguchi,
Hiroko Ishikawa,
Mie Fukuda
et al.
Abstract:Chinese hamster ovary (CHO) cells are widely used for the industrial production of therapeutic monoclonal antibodies (mAbs). To meet the increasing market demands, high productivity, and quality are required in cell culture. One of the critical attributes of mAbs, from a safety perspective, is mAb fragmentation. However, methods for preventing mAbs fragmentation in CHO cell culture are limited. In this study, we observed that the antibody fragment content increased with increasing titers in fed‐batch cultures … Show more
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