Catechin reduces atherosclerotic lesion development in apo E-deficient mice: A transcriptomic study

Auclair, Sylvain; Milenković, Dragan; Besson, Catherine; Chauvet, Stéphanie; Gueux, Elyett; Morand, Christine; Mazur, Andrzej; Scalbert, Augustin

doi:10.1016/j.atherosclerosis.2008.12.007

Cited by 98 publications

(89 citation statements)

References 66 publications

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“…Lipid metabolism is strongly affected by mutation in apoE-/-mice. 21 In contrast to the previous report, 2 we found that CRA did not reduce the level of TC. Moreover, CRA treatment for 12 weeks did not affect serum HDL or LDL levels.…”

Section: Discussioncontrasting

confidence: 56%

Corosolic Acid Ameliorates Atherosclerosis in Apolipoprotein E-Deficient Mice by Regulating the Nuclear Factor-κB Signaling Pathway and Inhibiting Monocyte Chemoattractant Protein-1 Expression

Chen

Yang

Zhang

et al. 2012

Circ J

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Section: Discussioncontrasting

confidence: 56%

Corosolic Acid Ameliorates Atherosclerosis in Apolipoprotein E-Deficient Mice by Regulating the Nuclear Factor-κB Signaling Pathway and Inhibiting Monocyte Chemoattractant Protein-1 Expression

Chen

Yang

Zhang

et al. 2012

Circ J

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“…Microarray analysis provides an elegant way of determining multiple changes that can occur following consumption of a single phytochemical. One such study found that oral administration of catechin to mice resulted in the modification of the expression of 450 genes [52].…”

Section: Mediterranean Dietary Pattern and Cancer Preventionmentioning

confidence: 99%

Cancers

Hoffman¹,

Gerber²

2011

The Mediterranean Diet

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“…Images were analyzed as previously described (3). The signal and background intensity values for each spot in both channels were obtained using ImaGene 6.0 software.…”

Section: Methodsmentioning

confidence: 99%

Insulin immuno-neutralization in fed chickens: effects on liver and muscle transcriptome

Simon¹,

Milenković

Godet³

et al. 2012

Physiological Genomics

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Chickens mimic an insulin-resistance state by exhibiting several peculiarities with regard to plasma glucose level and its control by insulin. To gain insight into the role of insulin in the control of chicken transcriptome, liver and leg muscle transcriptomes were compared in fed controls and “diabetic” chickens, at 5 h after insulin immuno-neutralization, using 20.7K-chicken oligo-microarrays. At a level of false discovery rate <0.01, 1,573 and 1,225 signals were significantly modified by insulin privation in liver and muscle, respectively. Microarray data agreed reasonably well with qRT-PCR and some protein level measurements. Differentially expressed mRNAs with human ID were classified using Biorag analysis and Ingenuity Pathway Analysis. Multiple metabolic pathways, structural proteins, transporters and proteins of intracellular trafficking, major signaling pathways, and elements of the transcriptional control machinery were largely represented in both tissues. At least 42 mRNAs have already been associated with diabetes, insulin resistance, obesity, energy expenditure, or identified as sensors of metabolism in mice or humans. The contribution of the pathways presently identified to chicken physiology (particularly those not yet related to insulin) needs to be evaluated in future studies. Other challenges include the characterization of “unknown” mRNAs and the identification of the steps or networks, which disturbed tissue transcriptome so extensively, quickly after the turning off of the insulin signal. In conclusion, pleiotropic effects of insulin in chickens are further evidenced; major pathways controlled by insulin in mammals have been conserved despite the presence of unique features of insulin signaling in chicken muscle.

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Catechin reduces atherosclerotic lesion development in apo E-deficient mice: A transcriptomic study

Cited by 98 publications

References 66 publications

Corosolic Acid Ameliorates Atherosclerosis in Apolipoprotein E-Deficient Mice by Regulating the Nuclear Factor-κB Signaling Pathway and Inhibiting Monocyte Chemoattractant Protein-1 Expression

Corosolic Acid Ameliorates Atherosclerosis in Apolipoprotein E-Deficient Mice by Regulating the Nuclear Factor-κB Signaling Pathway and Inhibiting Monocyte Chemoattractant Protein-1 Expression

Cancers

Insulin immuno-neutralization in fed chickens: effects on liver and muscle transcriptome

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