Catechin prevents endothelial dysfunction in the prediabetic stage of OLETF rats by reducing vascular NADPH oxidase activity and expression

Ihm, Sang‐Hyun; Lee, Jung-Ok; Kim, Sujin; Seung, Ki‐Bae; Schini‐Kerth, Valérie B.; Chang, Kyuk; Oak, Min–Ho

doi:10.1016/j.atherosclerosis.2009.01.036

Cited by 50 publications

(33 citation statements)

References 23 publications

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“…Since NO can counteract the effects of ET-1 Pernow et al, 2012), the suppression of oxidative stress would be effective against diabetic vascular dysfunction. Several studies reported increased expression and activity of NAD(P)H oxidase, one of the major sources of superoxide in vessels, in arteries from OLETF rats involving different vessels and stages of disease (Kim et al, 2003;Matsui et al, 2011), and green tea extract (Ihm et al, 2012) or catechin (Ihm et al, 2009) suppressed oxidative stress in the OLETF arteries. In the present study, on treatment with EGCG within the timescale studied here, the EGCG did not affect the protein expression of eNOS, SODs, or gp91 phox .…”

Section: Discussionmentioning

confidence: 98%

“…Based on this model, there have been several reports of vascular dysfunctions in various arteries (Kagota et al, 2000;Matsumoto et al, 2009b). Various studies on animal models of cardiovascular diseases have investigated the preventive effects of catechin or green tea when treatment is started before the onset of complications or at a young age (Ihm et al, 2009(Ihm et al, , 2012. However, treatment of T2DM patients does not begin until after they have been diagnosed, at which time, in many instances, complications are already present.…”

Section: Introductionmentioning

confidence: 97%

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Epigallocatechin gallate attenuates ET-1-induced contraction in carotid artery from type 2 diabetic OLETF rat at chronic stage of disease

et al. 2014

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 97%

Epigallocatechin gallate attenuates ET-1-induced contraction in carotid artery from type 2 diabetic OLETF rat at chronic stage of disease

et al. 2014

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“…Several medicinal plants offer potential for the prevention and treatment of cardiovascular diseases. (Ernst, 2005;Ihm et al, 2009) The best-selling herbal remedies in the USA and world-wide are formulations of Ginkgo biloba. It is reported that Ginkgo biloba extract is effective in the inhibition of platelet aggregation and thus it could be potentially used as an effective oral anti-platelet therapeutic agent.…”

Section: Discussionmentioning

confidence: 99%

Antiplatelet and Antithrombotic Activities of Lindera obtusiloba Extract in vitro and in vivo

Lee¹,

Kim²,

Lee³

et al. 2010

Biomolecules and Therapeutics

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-Several studies have shown that plant-derived polyphenols reduce cardiovascular accidents in high-risk patients and the inhibition of platelet function may be responsible for part of this benefit. Lindera obtusiloba is widely used in traditional herbal medicine for the treatment of cardiovascular and inflammatory diseases. Therefore, the antiplatelet and antithrombotic activities of Lindera obtusiloba Extracts (LOE) on in vitro platelet aggregation, radical scavenging activity and in vivo murine pulmonary thrombosis were examined. LOE was able to directly scavenge the stable DPPH radical in a concentration-dependent manner and its IC50 value was 3.9 ± 0.1 μg/ml. LOE significantly inhibited collagen-and ADP-induced platelet aggregation in a concentration-dependent manner and its IC 50 value is 0.9 ± 0.1 mg/ml and 0.4 ± 0.1 mg/ml respectively. The inhibitory effect of LOE was comparable to aspirin (IC50 values were 1.0 ± 0.5 and 1.0 ± 0.7 mg/ml, respectively). Furthermore, oral administration of LOE suppressed the death of mice with pulmonary thrombosis induced by intravenous injection of collagen plus epinephrine. Taken together, our results suggest LOE may be a promising candidate for antithrombotic agent, and the antithrombotic effect of LOE may be due to, at least in part, antiplatelet activity.

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“…Treatment of the OLETF rats with Cat resulted in the maintenance of BP, arterial NOX activity and expression, and the oxidative stress conditions in values similar to that observed in saline-treated LETO rats. (41) …”

Section: Flavanols Nitric Oxide and Oxidative Stress In Animal Studiesmentioning

confidence: 99%

Cocoa flavanols: effects on vascular nitric oxide and blood pressure

Fraga

Litterio

Prince

et al. 2010

J. Clin. Biochem. Nutr.

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Diets rich in fruits and vegetables have been associated with benefits for human health. Those effects have been partially ascribed to their content in flavonoids, compounds that are present in many edible plants and its derived foods. In humans, a significant number of studies has been developed analyzing the effect of foods and beverages rich in flavonoids on the presence and progression of risk factors associated to cardiovascular diseases, including hypertension. Cocoa derived products, rich in flavanols, have been thoroughly studied and demonstrated to be efficient improving endothelial function and decreasing blood pressure in humans and animals. However, the final chemical species and the mechanism/s responsible for these effects have not been completely defined. In this paper we present data supporting the hypothesis that flavanols could define superoxide anion production and then, establish optimal nitric oxide levels and blood pressure.

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Catechin prevents endothelial dysfunction in the prediabetic stage of OLETF rats by reducing vascular NADPH oxidase activity and expression

Cited by 50 publications

References 23 publications

Epigallocatechin gallate attenuates ET-1-induced contraction in carotid artery from type 2 diabetic OLETF rat at chronic stage of disease

Epigallocatechin gallate attenuates ET-1-induced contraction in carotid artery from type 2 diabetic OLETF rat at chronic stage of disease

Antiplatelet and Antithrombotic Activities of Lindera obtusiloba Extract in vitro and in vivo

Cocoa flavanols: effects on vascular nitric oxide and blood pressure

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