(+)-Catechin inhibits heart mitochondrial complex I and nitric oxide synthase: functional consequences on membrane potential and hydrogen peroxide production

Iglesias, Darío E.; Bombicino, Silvina Sonia; Boveris, Alberto; Valdez, Laura B.

doi:10.1039/c8fo01843j

Cited by 12 publications

(6 citation statements)

References 76 publications

(93 reference statements)

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“…Competition between flavonoids and ubiquinone for close binding sites has been suggested. Catechin also inhibits complex I in isolated rat heart mitochondria and decreases H 2 O 2 generation [137]. Nobiletin decreases mitochondrial oxygen consumption and H 2 O 2 production in the presence of glutamate and malate, but a slight increase has been observed with succinate [138].…”

Section: Flavonoids Attenuate Mitochondrial Ros Formationmentioning

confidence: 97%

Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?

Kicińska

Jarmuszkiewicz

2020

Molecules

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A large number of diverse mechanisms that lead to cytoprotection have been described to date. Perhaps, not surprisingly, the role of mitochondria in these phenomena is notable. In addition to being metabolic centers, due to their role in cell catabolism, ATP synthesis, and biosynthesis these organelles are triggers and/or end-effectors of a large number of signaling pathways. Their role in the regulation of the intrinsic apoptotic pathway, calcium homeostasis, and reactive oxygen species signaling is well documented. In this review, we aim to characterize the prospects of influencing cytoprotective mitochondrial signaling routes by natural substances of plant origin, namely, flavonoids (e.g., flavanones, flavones, flavonols, flavan-3-ols, anthocyanidins, and isoflavones). Flavonoids are a family of widely distributed plant secondary metabolites known for their beneficial effects on human health and are widely applied in traditional medicine. Their pharmacological characteristics include antioxidative, anticarcinogenic, anti-inflammatory, antibacterial, and antidiabetic properties. Here, we focus on presenting mitochondria-mediated cytoprotection against various insults. Thus, the role of flavonoids as antioxidants and modulators of antioxidant cellular response, apoptosis, mitochondrial biogenesis, autophagy, and fission and fusion is reported. Finally, an emerging field of flavonoid-mediated changes in the activity of mitochondrial ion channels and their role in cytoprotection is outlined.

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Section: Flavonoids Attenuate Mitochondrial Ros Formationmentioning

confidence: 97%

Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?

Kicińska

Jarmuszkiewicz

2020

Molecules

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“…Recent research showed that catechin also inhibits mitochondrial complex I, resulting in reduced mitochondrial membrane potential and less hydrogen peroxide production in isolated mitochondria (Iglesias et al., 2019). In contrast to the results obtained from quercetin treatment, catechin‐treated N2 exhibited a decrease in TMRE‐staining intensity with minimal reduction in neuronal defects in this study.…”

Section: Resultsmentioning

confidence: 99%

Flavonoids mitigate neurodegeneration in aged Caenorhabditis elegans by mitochondrial uncoupling

Cho

Song

Cho

2020

Food Science & Nutrition

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“…In earlier study, flavanol has appear to protect heart mitochondria via various mechanisms. This includes protection effect of flavanol via meddling with ETC complexes activities through deprivation of complex I activity, consequently mitochondrial membrane depolarization which then of ROS production (NO and H 2 O 2 ) [ 116 ]. This has been corroborated by previous study on T2DM model where epigallocatechin-3-gallate (EGCG), a flavanol, attenuated myocardial deterioration and showed beneficial effects on myocardial mitochondrial components.…”

Section: Therapeutic Role Of Flavonoid In Alleviating Mitochondrial Dysfunction-induced Oxidative Stress In Diabetic Cardiomyopathymentioning

confidence: 99%

Therapeutic Approach of Flavonoid in Ameliorating Diabetic Cardiomyopathy by Targeting Mitochondrial-Induced Oxidative Stress

Sapian

Taib

Latip

et al. 2021

IJMS

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Diabetes cardiomyopathy is one of the key factors of mortality among diabetic patients around the globe. One of the prior contributors to the progression of diabetic cardiomyopathy is cardiac mitochondrial dysfunction. The cardiac mitochondrial dysfunction can induce oxidative stress in cardiomyocytes and was found to be the cause of majority of the heart morphological and dynamical changes in diabetic cardiomyopathy. To slow down the occurrence of diabetic cardiomyopathy, it is crucial to discover therapeutic agents that target mitochondrial-induced oxidative stress. Flavonoid is a plentiful phytochemical in plants that shows a wide range of biological actions against human diseases. Flavonoids have been extensively documented for their ability to protect the heart from diabetic cardiomyopathy. Flavonoids’ ability to alleviate diabetic cardiomyopathy is primarily attributed to their antioxidant properties. In this review, we present the mechanisms involved in flavonoid therapies in ameliorating mitochondrial-induced oxidative stress in diabetic cardiomyopathy.

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(+)-Catechin inhibits heart mitochondrial complex I and nitric oxide synthase: functional consequences on membrane potential and hydrogen peroxide production

Abstract: The aim was to study the in vitro effect of nM to low μM concentration of (+)-catechin on the enzymatic activities of mitochondrial complex I and mtNOS, as well as the consequences on the membrane potential and H2O2 production rate.

Cited by 12 publications

References 76 publications

Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?

Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?

Flavonoids mitigate neurodegeneration in aged Caenorhabditis elegans by mitochondrial uncoupling

Therapeutic Approach of Flavonoid in Ameliorating Diabetic Cardiomyopathy by Targeting Mitochondrial-Induced Oxidative Stress

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