This thesis presents an advanced guidance and control system for unmanned aerial vehicles (UAV) with flexible wing. The control system is based on a stereo vision system and advanced fuzzy logic algorithms that can detect wing deflections and shapes. In general, this sensor has the capability, reliability, and performance of similar traditional control sensors, and provides reliable visual information that is useful for designing different control systems. The thesis proposes a novel Deflection-Detection-Vision-System (DDVS) to control a flexible wing of unmanned aerial vehicle (UAV). Ph.D. program advisor, Professor Jurek Z. Sasiadek, for his continued support and guidance. He provided advice, opportunities, and assistance that greatly enhanced my research experience. Many thanks to my mother, my father, and my brothers for the patience and the support in all my choices, no matter what they were. In particular, I thank my lovely wife and my children "Fatima, Mohammed Ridha and Zainab" for their company and understanding during this thesis activity. Last but not certainly least, I would also like to thank my friends and fellow students for the great time spent together and the experiences shared. v