Catch-up Growth in 60 Children with Celiac Disease

Damen, Gerard; Boersma, Bart; Wit, J. M.; Heymans, H. S. A.

doi:10.1097/00005176-199411000-00005

Cited by 66 publications

(44 citation statements)

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“…The introduction of a GFD in children with celiac disease promotes a faster growth rate and faster bone maturation (25,26) and may lead to the intake of hyperenergetic foods and secondary overweight (27). Consumption of the GFD for Ϸ1 y promoted a remarkable increase in body-compartment masses in our patients: the differences from healthy subjects observed before the dietary treatment began were no longer present.…”

Section: Discussionmentioning

confidence: 79%

Body composition in children with celiac disease and the effects of a gluten-free diet: a prospective case-control study

Barera

Mora

Brambilla

et al. 2000

The American Journal of Clinical Nutrition

105

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Background: Celiac disease is the most common cause of malnutrition in children of Western countries. Objective: The objective was to measure body composition in children at the time celiac disease was diagnosed and after consumption of a gluten-free diet (GFD). Design: We assessed body composition by dual-energy X-ray absorptiometry in 29 children and adolescents with a mean (± SD) age of 9.5 ± 3.4 y at the time celiac disease was diagnosed and in a subset of 20 patients after 1.2 ± 0.2 y of a GFD. We also studied 23 patients aged 21.2 ± 4.6 y who consumed a GFD for 10.6 ± 4.5 y. Each patient was matched with a healthy control subject of the same age and sex. Results: Untreated patients weighed less than control subjects (P = 0.04). Fat mass and bone mineral content were lower in the patients than in the control subjects (P < 0.01), as was lean mass of the limbs (P = 0.0013). After Ϸ1 y of the GFD, there were no significant differences in body-composition values between patients and control subjects. Similarly, body-composition values of celiac disease patients who consumed the GFD long term were comparable with those of healthy subjects. Conclusions: Remarkable abnormalities in body composition were found in children at the time of diagnosis of celiac disease. Appropriate dietary treatment reverses body-composition abnormalities quickly and the beneficial effects of gluten withdrawal are persistent. Because these results are harder to achieve if celiac disease is first diagnosed in adulthood, efforts to encourage early diagnosis of celiac disease should be made.Am J Clin Nutr 2000;72:71-5.

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Section: Discussionmentioning

confidence: 79%

Body composition in children with celiac disease and the effects of a gluten-free diet: a prospective case-control study

Barera

Mora

Brambilla

et al. 2000

The American Journal of Clinical Nutrition

105

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“…Coexisting thyroid or adrenal disease may confound the clinical assessment. Consequently, an investigation for celiac disease may be deferred until the child reaches adolescence; in such cases, there may be loss of ultimate height potential (15).…”

Section: The Case For Screening-michael Freemarkmentioning

confidence: 99%

Screening for Celiac Disease in Children With Type 1 Diabetes

2003

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“…The short time period was selected because it is the period for catch-up growth, as reported in children with celiac disease or late-onset primary hypothyroidism (44,45), and we believe it is a suitable model for catch-up growth in GHD children being treated with GH. The 1st y growth response is an indicator of growth to come (46).…”

mentioning

confidence: 99%

Validated Multivariate Models Predicting the Growth Response to GH Treatment in Individual Short Children with a Broad Range in GH Secretion Capacities

et al. 2000

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The aim of the study was to develop and validate models that could predict the growth responses to GH therapy of individual children. Models for prediction of the initial one and 2-y growth response were constructed from a cohort of 269 prepubertal children (Model group) with isolated GH deficiency or idiopathic short stature, using a nonlinear multivariate data fitting technique. Five sets of clinical information were used. The "Basic model" was created using auxological data from the year before the start of GH treatment and parental heights. In addition to Basic model data, the other four models included growth data from the first 2 y of life, or IGF-I, or GH secretion estimated during a provocation test (AITT) or a spontaneous GH secretion profile.The performance of the models was validated by calculating the differences between predicted and observed growth responses in 149 new GH treated children (Validation group) who fulfilled the inclusion criteria used in the original cohort. The SD of these differences (SD res ) in the validation group was compared with the SD res for the model group. For the 1st y, the SD res for the Basic model was 0.28 SDscores. The lowest SD res (0.19 SDscores), giving the most narrow prediction interval, was achieved adding the 24h GH profile and data on growth from the first 2 y of life to the Basic model. The models presented permit estimation of GH responsiveness in children over a broad range in GH secretion, and with an accuracy of the models substantially better than when using maximal GH response during an provocation test. The predicted individual growth response, calculated using a computer program, can serve as a guide for evidence-based decisions when selecting children to GH treatment. Abbreviations GHD, GH deficiency GHI, GH insensitivity ISS, idiopathic short stature IGFBP-3, IGF binding protein 3 AITT, arginin-insulin tolerance test GH max , the estimated maximal GH levelThe diagnosis of severe GH deficiency (GHD) on the one hand or complete GH insensitivity (GHI) on the other, usually is obvious in the short child in whom appropriate studies have excluded other causes for growth failure. Among children forming the continuum between these two extremes, diagnosis is more challenging; that is, children with partial GHD or those considered to have partial GHI, who may be classified as idiopathic short stature (ISS). Despite investigations and discussions aimed at attaining consensus on the diagnostic discrimination between GHD and ISS (1, 2), none of the clinical measures used to date provide a reliable means for categorizing these patients and for predicting the value of GH therapy (3). The effect of the GH axis on statural growth in an individual child depends on the interaction between GH secretion and GH responsiveness. With better understanding of conditions causing GH resistance (4 -7), the need to consider responsiveness to GH, as well as secretion of GH when interpreting the growth of a child has become more apparent.Traditionally, the diagnosis of GHD relies ...

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Catch-up Growth in 60 Children with Celiac Disease

Cited by 66 publications

References 0 publications

Body composition in children with celiac disease and the effects of a gluten-free diet: a prospective case-control study

Body composition in children with celiac disease and the effects of a gluten-free diet: a prospective case-control study

Screening for Celiac Disease in Children With Type 1 Diabetes

Validated Multivariate Models Predicting the Growth Response to GH Treatment in Individual Short Children with a Broad Range in GH Secretion Capacities

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