Catatonia and Parkinsonism due to extrapontine myelinolysis following rapid correction of hyponatremia

Koussa, Salam; Nasnas, R

doi:10.1007/s00415-003-0916-4

Cited by 20 publications

(11 citation statements)

References 14 publications

(30 reference statements)

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“…4,7 Modern investigators of catatonia have concluded that lorazepam and electroconvulsive therapy (ECT) effectively relieve or resolve catatonic episodes regardless of their etiology. 8Y11 In our experience, the previous response rate in treating catatonia with diazepam intravenous drip (IVD), midazolam intramuscular injection (IMI), neuroleptics, or ECT was 70.6% despite psychiatric or systemic etiologies.…”

mentioning

confidence: 99%

Lorazepam and Diazepam Rapidly Relieve Catatonic Features in Major Depression

Hung

Huang²

2006

Clinical Neuropharmacology

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We have proved that a modified strategy (ie, lorazepam intramuscular injection [IMI] or diazepam intravenous drip [IVD] if lorazepam IMI fails) can rapidly relieve catatonic features in patients with schizophrenia. During a period of 3 years, we identified 7 major depressive patients with catatonic features in the emergency unit of a general hospital. The patients were treated with lorazepam IMI (dose, 2 mg/mL.per ampule) once or twice during the first 2 hours. If lorazepam IMI failed, diazepam IVD (dose, 10 mg/2 mL.per ampule) in 500 mL normal saline every 8 hours for 1 day would be administered. The total complete remission rate to lorazepam IMI within 2 hours was 6 (85.7%) per 7 patients, and the total complete remission rate to benzodiazepines (lorazepam IMI and diazepam IVD) within 1 day was 7 (100%) of all 7 patients. These results highly suggest that this modified strategy can also rapidly relieve catatonic features in major depression within 1 day and attain a high complete remission rate, even without electroconvulsive therapy.

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confidence: 99%

Lorazepam and Diazepam Rapidly Relieve Catatonic Features in Major Depression

Hung

Huang²

2006

Clinical Neuropharmacology

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“…3 EPM'ye bağlı gelişen Parkinsonizm hastalarının tedavisinde dopaminerjik tedavilerin kullanımı klinikte belirgin fayda sağlamakta-dır. [9][10][11][12][13][16][17][18] Bu durum ise ozmotik demiyelinizasyon sendromunun tedavi edilebilir olduğunu dü-şündürmektedir. Literatürde 1993 yılından bugüne kadar izole EPM'ye sekonder gelişen Parkinsonizm tanılı 11 hasta bildirilmiştir ve olgumuzda da olduğu gibi tüm hastalarda hiponatreminin hızlı bir şekilde düzeltilmesi söz konusudur (Tablo 1).…”

Section: Olgu Sunumuunclassified

“…Literatürde 1993 yılından bugüne kadar izole EPM'ye sekonder gelişen Parkinsonizm tanılı 11 hasta bildirilmiştir ve olgumuzda da olduğu gibi tüm hastalarda hiponatreminin hızlı bir şekilde düzeltilmesi söz konusudur (Tablo 1). [9][10][11][12][13][14][15][16][17][18][19] Ayrıca, hastaların çoğunda önce hiponatremiye bağlı bir genel durumda kötüleşme, bundan bir süre sonra ise Parkinsonizm'in geliştiği dikkati çek-miştir. Hiponatremi tanısı almasıyla Parkinsonizm gelişmesinin saptanması arasındaki en kısa süre bir gün, en uzun süre 18 gündür.…”

Section: Olgu Sunumuunclassified

“…Hastaların minimum izlem süresi iki ay, maksimum izlem süresi ise dört yıl olarak bildirilmiştir (Tablo 1). [9][10][11][12][13][14][15][16][17][18][19] Bizim olgumuz da dört yıldır izlem altındadır ve progresyon göster-meyen ılımlı bir Parkinsonizm tablosu mevcuttur. Yaklaşık bir yıl önce olgunun pramipeksol tedavisi ile aşırı uyku yakınması olması üzerine tedavi levodopa+benserazid ile değiştirildi.…”

Section: Olgu Sunumuunclassified

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Isolated Extrapontine Myelinolysis Presenting with Parkinsonism: A Case Report and Review of the Literature

Demır¹,

Aslan²,

Bozdemir³

et al. 2015

Turkiye Klinikleri J Neur

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“…[67] A few reports have also described occurrence of catatonic syndrome as a rare manifestation due to EPM. [8–10]…”

Section: Introductionmentioning

confidence: 99%

Acute psychosis with a favorable outcome as a complication of central pontine/extrapontine myelinolysis in a middle aged man

2012

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Central pontine myelinolysis is a demyelinating condition affecting the pons characterized by an acute progressive quadriplegia, dysarthria, dysphagia, and alterations of consciousness. Pathologic features include prominent demyelination in the central pons with sparing of axons and neurons. This condition is usually associated with systemic disorders such as hyponatremia, chronic alcoholism, liver failure, severe burns, malignant neoplasms, hemorrhagic pancreatitis, hemodialysis, and sepsis. There are limited reports of psychosis in patients with central pontine/extrapontine myelinolysis (CPEM). We have described a case of CPEM with psychosis as a complication which recovered completely with treatment given for short duration using low dose atypical antipsychotic (quetiapine). We also discuss etiopathology and clinical outcome of psychosis in this rare neurological disorder.

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Catatonia and Parkinsonism due to extrapontine myelinolysis following rapid correction of hyponatremia

Cited by 20 publications

References 14 publications

Lorazepam and Diazepam Rapidly Relieve Catatonic Features in Major Depression

Lorazepam and Diazepam Rapidly Relieve Catatonic Features in Major Depression

Isolated Extrapontine Myelinolysis Presenting with Parkinsonism: A Case Report and Review of the Literature

Acute psychosis with a favorable outcome as a complication of central pontine/extrapontine myelinolysis in a middle aged man

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