Catatonia and Encephalopathy Associated With Paliperidone Palmitate

Coffey, Michael J.

doi:10.1097/jcp.0b013e31824b1b0c

Cited by 7 publications

(8 citation statements)

References 6 publications

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“…In a double-blind, placebo-controlled crossover study, patients who experienced chronic symptoms of catatonia and who were diagnosed with schizophrenia were recruited to help determine the efficacy of amineptine, a tricyclic antidepressant which also acts as a mixed serotonin and dopamine reuptake inhibitor and releasing agent, in treating catatonia in schizophrenic patients [ 72 ]. Amineptine has not been officially approved by the FDA for use in the United States.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…Each patient was treated for six weeks with either 200 mg amineptine or placebo daily in addition to any medications prescribed before the study began. They then received the alternative treatment for six weeks following a wash-out period of 3 weeks [ 72 ]. Patients were psychiatrically evaluated using eight clinical evaluation scales at weeks 0, 6, 9, and 15 [ 72 ].…”

Section: Clinical Studiesmentioning

confidence: 99%

“…They then received the alternative treatment for six weeks following a wash-out period of 3 weeks [ 72 ]. Patients were psychiatrically evaluated using eight clinical evaluation scales at weeks 0, 6, 9, and 15 [ 72 ]. In both patients with catatonic schizophrenia and in healthy individuals, there was no significant decrease in score relative to baseline on any of the clinical scales used when amineptine was administered instead of placebo ( p > 0.35) [ 72 ].…”

Section: Clinical Studiesmentioning

confidence: 99%

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Catatonia: Clinical Overview of the Diagnosis, Treatment, and Clinical Challenges

Edinoff

Kaufman

Hollier

et al. 2021

Neurology International

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Catatonia is a syndrome that has been associated with several mental illness disorders but that has also presented as a result of other medical conditions. Schizophrenia and other psychiatric disorders such as mania and depression are known to be associated with catatonia; however, several case reports have been published of certain medical conditions inducing catatonia, including hyponatremia, cerebral venous sinus thrombosis, and liver transplantation. Neuroleptic Malignant Syndrome and anti-NMDA receptor encephalitis are also prominent causes of catatonia. Patients taking benzodiazepines or clozapine are also at risk of developing catatonia following the withdrawal of these medications—it is speculated that the prolonged use of these medications increases gamma-aminobutyric acid (GABA) activity and that discontinuation may increase excitatory neurotransmission, leading to catatonia. The treatment of catatonia often involves the use of benzodiazepines, such as lorazepam, that can be used in combination therapy with antipsychotics. Definitive treatment may be found with electroconvulsive therapy (ECT). Aberrant neuronal activity in different motor pathways, defective neurotransmitter regulation, and impaired oligodendrocyte function have all been proposed as the pathophysiology behind catatonia. There are many clinical challenges that come with catatonia and, as early treatment is associated with better outcomes, it becomes imperative to understand these challenges. The purpose of this manuscript is to provide an overview of these challenges and to look at clinical studies regarding the pathophysiology, diagnosis, and treatment of as well as the complications and risk factors associated with catatonia.

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Section: Clinical Studiesmentioning

confidence: 99%

Section: Clinical Studiesmentioning

confidence: 99%

Section: Clinical Studiesmentioning

confidence: 99%

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Catatonia: Clinical Overview of the Diagnosis, Treatment, and Clinical Challenges

Edinoff

Kaufman

Hollier

et al. 2021

Neurology International

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“…[4] There are three types of catatonia, stuporous, excited and malignant. [5] Each is a different presentation of catatonia.…”

Section: Hhv-6 and Catatoniamentioning

confidence: 99%

An Investigation into the Significance of HHV-6 in Catatonia and Mental Health Disorders

Das

2021

Sus

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In this paper, the effects of all types of Human Herpes Virus (HHV-6) is reviewed in relation to encephalopathy, catatonia and mental health disorders due to recent research indicating that HHV-6 does a lot more than just causing Roseola, encephalitis and encephalopathy and that it could be the key to the recent rise in mental health disorders. The review suggests that the hypothesis that HHV-6 can lead to encephalopathy, catatonia and mental health disorders is true. The links between HHV-6, catatonia and mental health disorders are clear, and it seems necessary to do more research into the topic. It is possible HHV-6 plays a big role in causing catatonia among patients due to it causing encephalopathy and possibly causing and/or assisting the onset of mental health disorders, both of which are known to cause catatonia. HHV-6 is a relatively unknown pathogen to the wider population, but research is now indicating its prevalence and its effects could be behind the recent rise in mental health disorders.

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“…Therefore, we are basically dealing with an olanzapine overdose. No such syndrome has been reported in paliperidone palmitate so far, although cases of tardive dyskinesia, catatonia and encephalopathy have been found (Coffey, 2012;Lally et al, 2013). In our report we present a case study of a patient treated by paliperidone palmitate with an occurrence of severe acute dystonia/akathisia, which could be caused by rapid release of paliperidone to the blood stream.…”

mentioning

confidence: 90%

Severe acute dystonia/akathisia after paliperidone palmitate application – a case study

Ustohal¹,

Přikryl²,

Hublová³

et al. 2013

Int. J. Neuropsychopharm.

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Catatonia and Encephalopathy Associated With Paliperidone Palmitate

Cited by 7 publications

References 6 publications

Catatonia: Clinical Overview of the Diagnosis, Treatment, and Clinical Challenges

Catatonia: Clinical Overview of the Diagnosis, Treatment, and Clinical Challenges

An Investigation into the Significance of HHV-6 in Catatonia and Mental Health Disorders

Severe acute dystonia/akathisia after paliperidone palmitate application – a case study

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