Catastrophic antiphospholipid syndrome presented with sudden renal failure and history of long-lasting psychosis and hypertension in a 42 years old women

Mardani, Saeed; Nasri, Hamid

doi:10.5812/nephropathol.9215

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…Mardani et al [ 38 ] described a case of CAPS in a woman with psychosis and long-standing hypertension and a history of recurrent miscarriage. The patient was admitted to the hospital with complaints of confusion, asterixis, uncontrolled blood pressure, nausea, and vomiting.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Catastrophic Antiphospholipid Syndrome

Bitsadze,

Yakubova,

Khizroeva

et al. 2024

IJMS

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Unlike classic APS, CAPS causes multiple microthrombosis due to an increased inflammatory response, known as a “thrombotic storm”. CAPS typically develops after infection, trauma, or surgery and begins with the following symptoms: fever, thrombocytopenia, muscle weakness, visual and cognitive disturbances, abdominal pain, renal failure, and disseminated intravascular coagulation. Although the presence of antiphospholipid antibodies in the blood is one of the diagnostic criteria, the level of these antibodies can fluctuate significantly, which complicates the diagnostic process and can lead to erroneous interpretation of rapidly developing symptoms. Triple therapy is often used to treat CAPS, which includes the use of anticoagulants, plasmapheresis, and high doses of glucocorticosteroids and, in some cases, additional intravenous immunoglobulins. The use of LMWH is recommended as the drug of choice due to its anti-inflammatory and anticoagulant properties. CAPS is a multifactorial disease that requires not only an interdisciplinary approach but also highly qualified medical care, adequate and timely diagnosis, and appropriate prevention in the context of relapse or occurrence of the disease. Improved new clinical protocols and education of medical personnel regarding CAPS can significantly improve the therapeutic approach and reduce mortality rates.

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Section: Clinical Manifestationsmentioning

confidence: 99%

Catastrophic Antiphospholipid Syndrome

Bitsadze,

Yakubova,

Khizroeva

et al. 2024

IJMS

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“…Chronic renal failure is a progressive loss of renal function over a period of months or years (2)(3)(4)(5)(6)(7). Each of the kidneys has around a million tiny filters, called nephrons.…”

Section: World Kidney Day and Chronic Kidney Diseasementioning

confidence: 99%

“…Renal failure influences the whole body and can make the involved person feel very sick. Untreated renal insufficiency can be life-threatening (5)(6)(7). It should be reminded that early chronic renal failure has no signs or symptoms (8)(9)(10).…”

Section: World Kidney Day and Chronic Kidney Diseasementioning

confidence: 99%

World Kidney Day 2016: Awareness for Saving Kidneys

Nasri

Baradaran

et al. 2015

Shiraz E-Med J

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“…We would like to remind readers of a few points about APS nephropathy (APSN) and rheumatologic disease. Although high proportions of patients showing association of SSc and aPLs were described by Touré et al, more attention and support is needed to find the co-existence of APSN with systemic lupus erythematosus and SSc in routine evaluation of these patients [ 2 , 3 , 4 ]. Thus, the main question to bear in mind is: what do nephrologists or rheumatologists need to know about APS and APSN?…”

Section: Dear Editormentioning

confidence: 99%