Cataracts in systemic diseases and syndromes

Hutnik, Cindy; Nichols, Bruce D.

doi:10.1097/00055735-199902000-00005

Cited by 17 publications

(13 citation statements)

References 26 publications

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“…While the largest influencing factor for cataract formation is heredity, other risk factors such as smoking (29,30), steroid use (31), diabetes (29,32) and exposure to ionizing radiation also The statistical significance of the effect of radiation was determined by comparing each treatment group with the sham-radiation group with the matching diet supplement.…”

Section: Discussionmentioning

confidence: 99%

Dietary Supplements Reduce the Cataractogenic Potential of Proton and HZE-Particle Radiation in Mice

et al. 2010

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The present study was undertaken to investigate the ability of dietary supplements to reduce the formation and severity of cataracts in mice irradiated with high-energy protons or iron ions, which are important components of the radiation encountered by astronauts during space travel. The mice were exposed to proton or iron-ion radiation and fed with a control diet or diets supplemented with the soybean-derived protease inhibitor, Bowman-Birk inhibitor (BBI), in the form of BBI Concentrate (BBIC) or an antioxidant formulation [containing l-selenomethionine (SeM), N-acetyl cysteine (NAC), ascorbic acid, co-enzyme Q10, alpha-lipoic acid and vitamin E succinate] both before and after the radiation exposure. At approximately 2 years after the radiation exposure, the animals were killed humanely and lenses were harvested and characterized using an established classification system that assigns discrete scores based on the severity of the lens opacifications. The results showed that exposure to 1 GeV/nucleon proton (3 Gy) or iron-ion (50 cGy) radiation significantly increased the cataract prevalence and severity in CBA/J mice to levels above the baseline levels of age-induced cataract formation in this mouse strain. Treatment with BBIC or the antioxidant formulation significantly reduced the prevalence and severity of the lens opacifications in the mice exposed to iron-ion radiation. Treatment with BBIC or the antioxidant formulation also decreased the severity of the lens opacifications in the mice exposed to proton radiation; however, the decrease did not reach statistical significance. These results indicate that BBIC and the antioxidant formulation evaluated in this study could be useful for protecting astronauts against space radiation-induced cataracts during or after long-term manned space missions.

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Section: Discussionmentioning

confidence: 99%

Dietary Supplements Reduce the Cataractogenic Potential of Proton and HZE-Particle Radiation in Mice

et al. 2010

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“…The Beaver Dam Eye Study suggested that serum lipids, glycated haemoglobin and oxidative stress may play a role in cataractogenesis [15]. Cardiovascular disease and associated risk factors were not thought to affect the development of age-related cataract [2]. A weak association between atherosclerosis-related morbidity and visually significant cataract has been reported and is strongest for people aged 65 to 69 years [11].…”

Section: Cardiovascular Diseasementioning

confidence: 99%

“…The greatest risk factor is age. Diabetes mellitus is also associated with the development of cortical and posterior sub capsular cataract [1]. The Beaver Dam Eye Study and the Cataract Patient Outcomes Research Team have reported an association between age-related cataracts and systemic cardiovascular or atherosclerotic disease [2].…”

Section: Introductionmentioning

confidence: 99%

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The Relationship of Blood Glucose and Blood Pressure In Age-Related Cataracts

Dieu¹

2017

BJSTR

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“…Surgical excision of cataracts in patients with mitochondrial diseases has led to improved visual function and better quality of life. 32 …”

Section: Treatment Of Neurological Complicationsmentioning

confidence: 99%

How Can We Treat Mitochondrial Encephalomyopathies? Approaches to Therapy

2008

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Summary:Mitochondrial disorders are a heterogeneous group of diseases affecting different organs (brain, muscle, liver, and heart), and the severity of the disease is highly variable. The chronicity and heterogeneity, both clinically and genetically, means that many patients require surveillance follow-up over their lifetime, often involving multiple disciplines. Although our understanding of the genetic defects and their pathological impact underlying mitochondrial diseases has increased over the past decade, this has not been paralleled with regards to treatment. Currently, no definitive pharmacological treatment exists for patients with mitochondrial dysfunction, except for patients with primary deficiency of coenzyme Q10. Pharmacological and nonpharmacological treatments increasingly being investigated include ketogenic diet, exercise, and gene therapy. Management is aimed primarily at minimizing disability, preventing complications, and providing prognostic information and genetic counseling based on current best practice. Here, we evaluate therapies used previously and review current and future treatment modalities for both adults and children with mitochondrial disease.

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Cataracts in systemic diseases and syndromes

Cited by 17 publications

References 26 publications

Dietary Supplements Reduce the Cataractogenic Potential of Proton and HZE-Particle Radiation in Mice

Dietary Supplements Reduce the Cataractogenic Potential of Proton and HZE-Particle Radiation in Mice

The Relationship of Blood Glucose and Blood Pressure In Age-Related Cataracts

How Can We Treat Mitochondrial Encephalomyopathies? Approaches to Therapy

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