Cataract surgery outcomes in adult patients with Down's syndrome: Table 1

Trisomy 21, the presence of a supernumerary chromosome 21, results in a collection of clinical features commonly known as Down syndrome (DS). DS is among the most genetically complex of the conditions that are compatible with human survival post-term, and the most frequent survivable autosomal aneuploidy. Mouse models of DS, involving trisomy of all or part of human chromosome 21 or orthologous mouse genomic regions, are providing valuable insights into the contribution of triplicated genes or groups of genes to the many clinical manifestations in DS. This endeavour is challenging, as there are >200 protein-coding genes on chromosome 21 and they can have direct and indirect effects on homeostasis in cells, tissues, organs and systems. Although this complexity poses formidable challenges to understanding the underlying molecular basis for each of the many clinical features of DS, it also provides opportunities for improving understanding of genetic mechanisms underlying the development and function of many cell types, tissues, organs and systems. Since the first description of trisomy 21, we have learned much about intellectual

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“…Treatment and corrective aids should be given promptly 157 . Cataract surgery is routinely performed, usually with good outcomes 192,193 .…”

Section: Hearing and Visionmentioning

confidence: 99%

Down syndrome

Antonarakis

Skotko

Rafii

et al. 2020

Nat Rev Dis Primers

435

492

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“…Inclusion criteria involved all cataract patients operated by means of phacoemulsification in the time of interest. Exclusion criteria were cataracts beyond age-related reasons such as congenital [ 8 ], traumatic [ 9 ], drug induced [ 10 - 12 ], and due to inflammatory causes [ 13 ]. Four cases of post-cataract surgery endophthalmitis were also excluded as irrelevant to the aim of the study.…”

Section: Methodsmentioning

confidence: 99%

Reoperations After Cataract Surgery: Is the Incidence Predictable Through a Risk Factor Stratification System?

Oustoglou¹,

Tzamalis²,

Mamais³

et al. 2020

Cureus

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Introduction The objective of the study was to quantify the number of procedures needed to achieve the best possible surgical outcome, depending on the number and type of risk factors identified. Methods Two independent observers reviewed the medical records of 1,502 patients who underwent phacoemulsification surgery, during a two-year period (January 1, 2014 to December 31, 2015). Preoperative risk factors were documented according to the stratification system used. Based on the total risk score, each case was allocated to one of four risk groups with 0, 1-2, 3-5, and >6 total risk factors, respectively. All qualitative and quantitative characteristics were gathered and included in a multivariate analysis. Results A total of 1,792 eyes were included. Αge over 88 years, low cooperation ability with the patient, and surgeries performed by residents tended to have more often complications, while white/intumescent cataract, iridodonesis/phacodonesis, α1 blockers intake, and male gender are risk factors positively associated with more than one surgery. Conclusions Risk factors tend to be prognostic for possible intraoperative complications. The number of procedures needed for the best possible surgical outcome seems to depend on these preoperative risk factors. A stratification method increases the level of awareness of the surgeon, and therefore may decrease the number of complications and even procedures while enhancing the "safe" practice and skills of residents.

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“…The most common post-operative complication was PCO (8 eyes, 24.2%). 26 None of the aforementioned studies of cataract extraction in patients with Down syndrome specifically reported on post-operative inflammation. Cataract extraction with or without intraocular lens (IOL) implantation in pediatric patients with Down syndrome may be safe, effective, and without a higher rate of surgical complications than cataract surgery in the general pediatric population, though further longitudinal studies are required.…”

Section: Cataractsmentioning

confidence: 99%

“… 1 – 6 Physicians are generally most familiar with the facial appearance and intellectual disability associated with Down syndrome. However, Down syndrome has also been associated with numerous ophthalmologic manifestations, 7 – 12 including patterns of strabismus, 13 , 14 amblyopia, 15 , 16 nystagmus, 17 , 18 nasolacrimal duct obstruction (NLDO), 19 , 20 keratoconus, 21 , 22 eyelid abnormalities, 8 , 23 , 24 cataract, 25 , 26 optic nerve abnormalities, 27 glaucoma, 28 – 30 and retinal abnormalities. 7 , 31 Whenever appropriate, epidemiology, presentation, mechanisms, and management of these manifestations will be discussed.…”

Section: Introductionmentioning

confidence: 99%

Down syndrome: a review of ocular manifestations

et al. 2022

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Down syndrome is the most common genetically mediated intellectual disability. Although many physiologic and pathologic features of Down syndrome are discussed at length in the literature, the ocular manifestations of Down syndrome have seldom been discussed in a comprehensive fashion. Given that Down syndrome has ocular manifestations from the front to the back of the eye, it is important for physicians to become familiar with these manifestations, especially given the prevalence of Down syndrome. This review aims to discuss the varied ophthalmologic manifestations of Down syndrome – including strabismus, amblyopia, nystagmus, accommodation deficits, nasolacrimal duct obstruction, keratoconus, optic nerve pathology, neoplastic disease, and retinal pathology – to facilitate better care and visual outcomes in this important patient population.

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Cataract surgery outcomes in adult patients with Down's syndrome: Table 1

Abstract: A high incidence of bilateral cataracts as well as white cataracts was observed in patients with Down's syndrome in our study. Although the surgical outcomes of cataract surgery were good, the visual outcomes were suboptimal in our cases due to associated ocular comorbidities.

Cited by 13 publications

References 25 publications

Down syndrome

Down syndrome

Reoperations After Cataract Surgery: Is the Incidence Predictable Through a Risk Factor Stratification System?

Down syndrome: a review of ocular manifestations

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