Cataract surgery for congenital cataract: Endothelial cell characteristics, corneal thickness, and impact on intraocular pressure

Nilforushan, Naveed; Falavarjani, Khalil Ghasemi; Razeghinejad, Mohammad Reza; Bakhtiari, Pejman

doi:10.1016/j.jaapos.2006.08.017

Cited by 28 publications

(20 citation statements)

References 15 publications

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“…In addition, pediatric cataract patients survive longer than adult cataract patients, so it is more important to know how IOL implantation affects the corneal endothelium over the long term. During the last decade, several studies have investigated corneal endothelial changes after pediatric cataract surgery [37][38][39]. In 1992, Kora et al [40] reported endothelial cell loss in 12 eyes of pediatric patients who received lens removal through phacoemulsification and IOL implantation.…”

Section: Discussionmentioning

confidence: 99%

“…However, the short follow-up period limited this study's ability to analyze long-term changes of the corneal endothelium. In 2007, Nilforushan et al [39] studied the endothelial characteristics of congenital cataract patients after surgery, compared with age-and sex-matched controls. There was no statistically significant difference in ECD and CV, but CCT was greater in the patient group than in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, several studies have reported changes in corneal endothelial cells following pediatric cataract surgery [37][38][39][40]. However, these results are from small groups of patients, or were deduced based on short-term follow-up studies.…”

Section: Introductionmentioning

confidence: 99%

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Long-term follow-up of changes in corneal endothelium after primary and secondary intraocular lens implantations in children

Kim

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Long-term follow-up of changes in corneal endothelium after primary and secondary intraocular lens implantations in children

Kim

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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“…6 This finding is in contrast to the study done by Ramasubramanian et al 7 who had the viewpoint that surgical trauma at the time of cataract extraction can cause endothelial cell dysfunction and resultant increase in CCT. Another school of thought for risk of developing glaucoma being more in aphakic group rather than in primary pseudophakia group is due to the exposure of the maturing angle structures and maturing cornea to harmful side effects of vitreous components.…”

Section: Discussionmentioning

confidence: 64%

A Comparative Study of Increase in Central Corneal Thickness Following Congenital Cataract Surgery in Children

Chandrakumar¹,

Thasneemsuraiya²,

Anujoseph³

et al. 2017

jemds

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BACKGROUNDThe incidence rate of paediatric cataracts is high in developing countries like India 1 ; about 7.4 -15.3 % of childhood blindness is due to congenital cataract. Although cataract extraction is performed at early ages in these children to prevent stimulus deprivation amblyopia, other complications such as secondary glaucoma, 2 continue to threaten their long term visual outcome. It was observed that after congenital cataract extraction, the increase in central corneal thickness (CCT) leads to overestimation of Intraocular Pressure (IOP) by Goldman Applanation Tonometry (GAT); and hence overdiagnosis of glaucoma in operated children resulting in unnecessary use of antiglaucoma medications.Aims and Objectives-1) To determine the central corneal thickness in children following surgery for congenital cataract in primary/secondary pseudophakia and aphakia and compare with age-matched normal children. 2) To see the variation in central corneal thickness (CCT) following primary/secondary Posterior Chamber Intraocular Lens (PCIOL) implantation for congenital cataract. MATERIALS AND METHODSThis is a descriptive comparative study conducted among children under 12 years of age who underwent surgery for congenital cataract, who attended the Outpatient Department (OPD) as well as wards of Department of Ophthalmology and/or Institute of Paediatrics at Government Rajaji Hospital, Madurai. The duration of study was 10 months. Subjects, who fulfilled all eligibility criteria, and none of the exclusion criteria, were only recruited in this study after obtaining written informed consent from their parents/guardian. Out of 170 eyes included in this study, 27 were aphakic, 74 were pseudophakic eyes (46 with primary intraocular lens implantation and 28 with secondary intraocular lens implantation) and 69 unoperated eyes in these subjects were taken as controls as preliminary CCT values were unavailable for the aphakic/pseudophakic eyes. A detailed evaluation of the anterior and posterior segment (dilated fundus examination) was done. Visual acuity was recorded in cooperative children. After explaining both the procedures; IOP & CCT measurement; topical anaesthetic drops (0.5% proparacaine) were instilled into the conjunctival sac. Intraocular pressure was recorded with GAT and in uncooperative children with Perkin's handheld Applanation tonometer. After 5 minutes, child is reassured and asked to fix at a distant target. CCT was measured using ultrasonic pachymeter by placing the tip of the probe gently on the centre of cornea. An average of 5 readings is taken. Uncooperative children were examined under oral sedatives. After IOP and CCT measurement, these were compared to the IOP and CCT readings of their corresponding age-matched healthy children. RESULTSThe age distribution of cases and controls varied from 4 -12 years. There was no significant difference in age between the study group and control group. Among the 85 children (170 eyes) studied, 52 were male and 33 were female. In the study group, total number of...

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“…Nilforushan e associados relataram em um estudo semelhante, um aumento na ECC em crianças afácicas comparadas com crianças fácicas de idade e contagem celular endotelial semelhante. (16) A influência da idade na ECC não é clara. Day e Gunderson (17) não encontraram diferença na ECC entre um grupo de crianças mais jovens com 2 anos de idade e um grupo com 18 anos de idade.…”

Section: Discussionunclassified

Espessura central da córnea: catarata congênita, pseudofacia e afacia

Santos

Siqueira

Salomão

et al. 2010

Rev. bras.oftalmol.

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RESUMOObjetivo: Comparação da espessura central da córnea entre crianças com cristalino transparente (controle), catarata, pseudofácicas e afácicas. Estudo prospectivo, observacional. Métodos: Noventa e quatro olhos de 47 crianças foram submetidos à medida da espessura central corneana (ECC) e comparou-se o grupo controle (cristalino transparente) aos pacientes que apresentavam catarata, afacia ou pseudofacia. Pacientes com Síndrome de Down, aniridia, Síndrome de Marfan, glaucoma, anormalidades do segmento anterior ou pressão intraocular maior que 30 mmHg foram excluídos do estudo. Resultados: Dos 94 olhos estudados, 52 faziam parte do grupo controle com ECC média 533,6 µm. No grupo com catarata (n=27) a ECC média foi de 532,3 µm, enquanto no grupo de afácicos (n=8) e pseudofácicos (n=12) de 585,63 µ e 585,7 µ, respectivamente. Conclusão: A espessura central da córnea é semelhante em olhos com catarata congênita e olhos fácicos, sendo mais espessa após a cirurgia de catarata com ou sem implante de lente intraocular.

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Cataract surgery for congenital cataract: Endothelial cell characteristics, corneal thickness, and impact on intraocular pressure

Cited by 28 publications

References 15 publications

Long-term follow-up of changes in corneal endothelium after primary and secondary intraocular lens implantations in children

Long-term follow-up of changes in corneal endothelium after primary and secondary intraocular lens implantations in children

A Comparative Study of Increase in Central Corneal Thickness Following Congenital Cataract Surgery in Children

Espessura central da córnea: catarata congênita, pseudofacia e afacia

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