Cataract Surgery Considerations for Diabetic Patients

Go, Jonathan A.; Mamalis, Christina; Khandelwal, Sumitra

doi:10.1007/s11892-021-01418-z

Cited by 5 publications

(3 citation statements)

References 164 publications

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“…inflammation could also lead to CME via inflammatory factors such as leukotrienes and prostaglandins [1] . Even in patients without major risk factors for CME such as diabetes and operative complications, the rate of pseudophakic CME is reported as high as 1.17% [25][26] . This rate is much higher in patients with major risk factors, although modern phacoemulsification techniques have helped reduce the adverse events [25][26][27] .…”

Section: Tri-moxi Plus Drops Reduce Postop Inflammation and Infectionmentioning

confidence: 99%

“…Even in patients without major risk factors for CME such as diabetes and operative complications, the rate of pseudophakic CME is reported as high as 1.17% [25][26] . This rate is much higher in patients with major risk factors, although modern phacoemulsification techniques have helped reduce the adverse events [25][26][27] . Treatment and prevention of CME are achieved by anti-inflammatory agents targeting the aforementioned inflammatory mediators such as NSAIDs and corticosteroids [28][29] .…”

Section: Tri-moxi Plus Drops Reduce Postop Inflammation and Infectionmentioning

confidence: 99%

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Combinative approach of transzonular triamcinolone-moxifloxacin and perioperative drops to minimize postoperative complications of cataract surgery

Rabiee,

Gaspari,

Haseeb

et al. 2024

Int J Ophthalmol

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AIM: To investigate the effectiveness of combination therapy with transzonular triamcinolone-moxifloxacin and conventional perioperative drops in reducing postoperative complications of cataract surgery. METHODS: Electronic medical records of cataract surgery patients (single surgeon) were reviewed from January 2018 to September 2021. The rate of postoperative complications including prolonged and/or recurrent postoperative inflammation, endophthalmitis, cystoid macular edema (CME), and intraocular pressure (IOP) was compared between the patients receiving combinative therapy and patients receiving drops only. RESULTS: Totally 596 patients and 1057 eyes (Combinative-Therapy group 493 and Drop-Only group 564) were included in this study. Using combination therapy reduced the relative risk of postoperative inflammation by 26.9% (16.6% Combinative-Therapy vs 22.7% Drop-Only, P=0.013). The incidence of endophthalmitis was 0 in Combinative-Therapy group vs 0.5% in Drop-Only group (relative risk reduction 100%), although not statistically significant (P=0.10). The incidence of severe IOP spikes was not significantly different between Combinative-Therapy (2.4%) and Drop-Only (1.6%) groups (P=0.33). The relative risk of postoperative CME was 51.4% less in three months follow up visit in Combinative-Therapy group, although not statistically significant (P=0.07). The visual outcome 1-month postop. (best corrected visual acuity) was significantly better in Combinative-Therapy (logMAR 0.10) compared to Drop-Only (logMAR 0.14) groups (P=0.02) while the baseline visual acuity was not significantly different. CONCLUSION: The combinative approach of transzonular triamcinolone-moxifloxacin plus perioperative eyedrops is an effective method to minimize postoperative inflammation, with better visual outcomes. It could potentially reduce the risk of postoperative endophthalmitis and CME (near-significant P-values; larger studies could analyze better considering low incidence).

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Section: Tri-moxi Plus Drops Reduce Postop Inflammation and Infectionmentioning

confidence: 99%

Section: Tri-moxi Plus Drops Reduce Postop Inflammation and Infectionmentioning

confidence: 99%

Combinative approach of transzonular triamcinolone-moxifloxacin and perioperative drops to minimize postoperative complications of cataract surgery

Rabiee,

Gaspari,

Haseeb

et al. 2024

Int J Ophthalmol

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“…Hyperglycemia in diabetes mellitus causes diabetic cataracts, often accompanied by retinopathy, resulting in vision loss [2]. Surgical therapy is the standard treatment for diabetic cataracts [3]. However, as the number of patients with diabetes increases, less invasive and simpler treatment methods become ideal.…”

Section: Introductionmentioning

confidence: 99%

Effects of Angiotensin Receptor Blockers on Streptozotocin-Induced Diabetic Cataracts

Ishigooka,

Mizuno,

Oosuka

et al. 2023

JCM

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This study aimed to determine the role of oxidative stress produced by the renin–angiotensin system (RAS) in cataract formation in streptozotocin-induced diabetic rats (STZ) using angiotensin II receptor blockers (ARBs). Rats were treated with streptozotocin and orally administered candesartan (2.5 mg/kg/day) or a normal diet for 10 weeks until sacrifice. Cataract progression was assessed through a slit-lamp examination. Animals were euthanized at 18 weeks, and the degree of cataract progression was evaluated. Oxidative stress was also assessed. In STZ-treated rats, lens opacity occurred at 12 weeks. Cataract progression was inhibited in the ARB-treated group compared with the placebo group (p < 0.05). STZ-treated rats exhibited upregulated angiotensin-converting enzyme (ACE) gene expression than control rats. Oxidative stress-related factors were upregulated in the placebo-treated group but suppressed in the ARB-treated group. A correlation coefficient test revealed a positive correlation between ACE gene expression and oxidative stress-related factors and a negative correlation between ACE and superoxide dismutase. Immunostaining revealed oxidative stress-related factors and advanced glycation end products in the lens cortex of the placebo-treated group. The mechanism of diabetic cataracts may be related to RAS, and the increase in focal ACE and angiotensin II in the lens promotes oxidative stress-related factor production.

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Early macular edema recognition after cataract surgery based on U-Net assisted optical coherence tomography

Liu,

Wang

2024

Journal of Radiation Research and Applied Sciences

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Cataract Surgery Considerations for Diabetic Patients

Cited by 5 publications

References 164 publications

Combinative approach of transzonular triamcinolone-moxifloxacin and perioperative drops to minimize postoperative complications of cataract surgery

Combinative approach of transzonular triamcinolone-moxifloxacin and perioperative drops to minimize postoperative complications of cataract surgery

Effects of Angiotensin Receptor Blockers on Streptozotocin-Induced Diabetic Cataracts

Early macular edema recognition after cataract surgery based on U-Net assisted optical coherence tomography

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