Cataract-prone variants of γD-crystallin populate a conformation with a partially unfolded N-terminal domain under native conditions
Sara Volz,
Jadyn R. Malone,
Alex J. Guseman
et al.
Abstract:Human γD-crystallin, a monomeric protein abundant in the eye lens nucleus, must remain stably folded for an individual’s entire lifetime to avoid aggregation and protein deposition-associated cataract formation. γD-crystallin contains two homologous domains, an N-terminal domain (NTD) and a C-terminal domain (CTD), which interact via a hydrophobic interface. A number of familial mutations in the gamma crystallin gene are linked to congenital early-onset cataract, most of which result in amino acid changes in t… Show more
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