Cataract patients in a defined Swedish population 1986–1990

Ninn-Pedersen, K; Bauer, Birgitta

doi:10.1111/j.1600-0420.1997.tb00149.x

Cited by 49 publications

(26 citation statements)

References 13 publications

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“…This may be attributable to the limited number of patients, since the power of the study with regard to sex was only 42%, based on a standardized difference of 0.2 (as calculated from the study of Ninn-Pedersen and Bauer, 1997) or from the association being weak. There are several studies indicating female sex as a risk for PCO development [16, 18, 19], and they are supported by the present findings. However, others have not shown this sex difference [12, 17, 20], indicating that the impact of sex, if any, is relatively small.…”

Section: Discussionsupporting

confidence: 91%

“…Suggested risk factors for PCO are age [14-17], female sex [16, 18, 19], pseudoexfoliation [20, 21], diabetes mellitus [22-25], uveitis [26-29], retinitis pigmentosa [18] and myopia [30, 31]. The present study was designed to study human lens epithelial cells (HLEC) from cataract patients in culture and investigate if cell growth was associated with suggested risk factors for PCO.…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Growth of Lens Epithelial Cells from Cataract Patients - Association with Possible Risk Factors for Posterior Capsule Opacification

Sundelin¹,

Petersen²,

Soltanpour³

et al. 2014

TOOPHTJ

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Aim : Inter-individual differences in intrinsic proliferative capacity of lens epithelial cells may have importance for the risk of developing posterior capsule opacification (PCO) after cataract surgery. The purpose of the present study was to determine growth of human lens epithelial cells (HLEC) in culture and investigate possible associations with clinical characteristics of the donors, such as age, sex, pseudoexfoliation, uveitis and diabetes.Methods : Pieces of lens capsule and adhering lens epithelial cells were obtained through capsulorhexis at cataract surgery. Specimens were cultured in a humidified CO2-incubator using standard culture medium and 5% fetal calf serum for two weeks after which cultured cells were stained with carboxy-fluorescein diacetate succinimidyl ester. Image processing software was used to determine the area of the confluent epithelial cell layer in relation to the size of the original capsule specimen.Results : The increase in area of confluent HLEC showed a negative correlation with diabetes at the first week after surgery. Lower age and female sex showed border-line significant associations with a higher rate of cell proliferation. The presence of pseudoexfoliation in vivo did not significantly affect cell growth in culture postoperatively. Nor did installation of xylocain in the anterior chamber during surgery.Conclusion : Diabetes is associated with lower rate of proliferation of lens epithelial cells in culture. The lack of strong correlations between in vitro growth and known risk factors for PCO in the donors suggest that other factors than the proliferative capacity of the cells per se are important for PCO formation.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

In Vitro Growth of Lens Epithelial Cells from Cataract Patients - Association with Possible Risk Factors for Posterior Capsule Opacification

Sundelin¹,

Petersen²,

Soltanpour³

et al. 2014

TOOPHTJ

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show abstract

“…PCO development is influenced by several factors such as patient age, type of surgery, materials and designs of intraocular lenses, and the follow-up period making it difficult to compare the incidence among different studies. In the current study a higher incidence of PCO, when compared to the incidence reported for the general population, is likely related to the high prevalence of PSC cataract, treatment with systemic corticosteroids, and to a younger mean age, all of which have been linked to posterior capsular opacification [33,34,35]. Interestingly, the 18% PCO incidence noted in this study is much lower than the 44% PCO incidence reported by our group in 2001 in recipients of bone marrow transplants that underwent cataract surgery, this reduction in the incidence of PCO may be influenced by advancement in surgical techniques and intraocular lenses as reported for the general population.…”

Section: Discussionmentioning

confidence: 91%

Outcomes of phacoemulsification in patients with chronic ocular graft-versus-host disease

Saboo

Amparo

Shikari

et al. 2015

Graefes Arch Clin Exp Ophthalmol

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Purpose To evaluate the outcomes of phacoemulsification in patients with ocular graft-versus-host disease (GVHD). Methods The occurrence of cataract, cataract surgery and its outcomes were analyzed in the medical records of 229 patients (458 eyes) with ocular GVHD. Outcome measures included pre- and postoperative corrected distance visual acuity (CDVA) and the rate of postoperative complications. Results From 458 eyes evaluated 58 were pseudophakic, from the 400 phakic eyes 238 (59%) presented with cataracts and 62 (26%) underwent cataract surgery. Analysis of postoperative complications and visual outcomes at one month was performed in 51 eyes in which detailed surgical and immediate postoperative records were available. Preoperatively, the mean CDVA was 0.67±0.57 LogMAR (Snellen 20/93) and improved postoperatively to 0.17±0.18 (Snellen 20/29) at one month (P<0.0001), and to 0.13±0.14 (Snellen 20/26) by the final follow-up visit (P<0.0001). Postoperative complications included: corneal epithelial defects (8%), filamentary keratitis (6%), worsening of corneal epitheliopathy (16%), posterior capsular opacification (18%), and cystoid macular edema (4%). A corrected distance visual acuity of 20/30 or better was achieved in 87% of the eyes; suboptimal CDVA improvement was accounted by severe ocular surface disease, pre-existing advanced glaucoma, and prior macular surgery. Conclusions Phacoemulsification in patients with chronic ocular GVHD is a safe and efficacious procedure resulting in significant visual improvement. Overall, postoperative adverse events responded well to timely management.

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“…The estimated prevalence of unilateral pseudophakia in North Carolina increased from 7.6% to 9.8% between 1998 and 2002, with the prevalence of bilateral pseudophakia more than doubling 71. Between 1986 and 1990 the number of cataract operations in Sweden rose from 227 to 328 per 100 000 of population and in the UK, the rate of cataract surgery increased 3.7-fold between 1989 and 2004 72 73. The estimated prevalence of pseudophakia or aphakia in the US is 5.1% in those >40 years old (6.1 million), and this is expected to rise (to 9.5 million) by 2020 74…”

Section: Resultsmentioning

confidence: 99%

The epidemiology of rhegmatogenous retinal detachment: geographical variation and clinical associations

Mitry

Charteris

Fleck

et al. 2009

British Journal of Ophthalmology

396

270

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Estimates of RRD incidence have varied threefold, but inclusion criteria and other design features have differed across studies making direct comparisons difficult. The overall incidence of RRD is not yet well established: more incidence studies of adequate methodology are needed to explore temporal changes in incidence. RRD incidence varies with ethnicity and is strongly associated with increasing age, myopia and certain vitreo-retinal degenerations. Due to changes in cataract surgery trends, the proportion of pseudophakic RRD presenting to specialised centres appears to be increasing.

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Cataract patients in a defined Swedish population 1986–1990

Abstract: In this material, the most important predisposing factors for YAG laser capsulotomy after extracapsular cataract surgery are: young age, female gender, if the patient was operated late in the period observed, and if the patient came from an urban area.

Cited by 49 publications

References 13 publications

In Vitro Growth of Lens Epithelial Cells from Cataract Patients - Association with Possible Risk Factors for Posterior Capsule Opacification

In Vitro Growth of Lens Epithelial Cells from Cataract Patients - Association with Possible Risk Factors for Posterior Capsule Opacification

Outcomes of phacoemulsification in patients with chronic ocular graft-versus-host disease

The epidemiology of rhegmatogenous retinal detachment: geographical variation and clinical associations

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