Catalyzed exchange between tritium gas and organic molecules in solution

Tritium labelling of antidepressants with regard to their chemical structure

“…A relationship between the volume of solvent and the efficiency of labelling was also measured. W e applied systematically t h i s process of i n nLtu catalyzed general label1 ing (6) From t h e r e s u l t s given i n t a b l e 1, i t appeared t h a t molecules w i t h a dihydrobenzoazepine skeleton underwent r e l a t i v e l y h i g h i s o t o p i c exchange. However, when t h e molecular s t r u c t u r e was o f t h e dibenzocycloheptadiene type, which includes a double bond between the carbon i n p o s i t i o n 5 and the a l i p h a t i c moiety, low s p e c i f i c a c t i v i t i e s were reached.…”

“…A relationship between the volume of solvent and the efficiency of labelling was also measured. W e applied systematically t h i s process of i n nLtu catalyzed general label1 ing (6) The presence of a double bond between the central carbon and the aliphatic chain (nortriptyline I I c ) resulted i n a drastic decrease of the number of hydrogen atoms exchanged. I t seems that a high conjugation effect takes place between the aromatic rings and the seven membered ring, causing the delocalization of the double bond.…”

Synthesis of tritium-labelled biologically important diazines

“…The catalyst PtO 2 was more active than PdO in the isotope exchange reaction. 115 Evans et al 114 conducted the isotope exchange reaction in a phosphate buffer in the presence of a PdO/BaSO 4 catalyst. Tritium was incorporated into carbohydrates, aliphatic and aromatic amino acids and nucleic acid components.…”

A simple method for the synthesis of specific [2H] and [3H]labelled methyl‐hydroxylated derivatives of 7,12‐dimethylbenz[a]anthracene

“…Randomly [ 3H] labelled compounds have been prepared by a catalytic exchange reaction which involved passing gaseous tritium through a solution of organic compounds in the presence of platinum oxide or palladium black (8).…”

“…1B) and yielded 2.1 mg (84% yield) with specific activity of 1.67 Ci/mmol. ( 8 ) This compound was prepared in 88% yield by the reaction of compound 11 (2.5 mg, 9.3 pmol) with NaBT4 (100 mCi, 20 pmol) by the same procedure as described for I . and the specific activity of HPLC purified 8 was found to be 1.68 Ci/mmol.…”