“…It has been hypothesized that the earliest enzymes on Earth might have arisen from the spontaneous self-assembly of short peptides to form supramolecular structures. − Specifically, it has been suggested that amyloids may have acted as the scaffold supporting primitive catalytic activities. , As amyloids use amino acid sequences as their building blocks, and their assembly is driven and sustained by noncovalent interactions, they share similarities with natural proteins . In favor of this hypothesis, several artificial amyloids formed by short, and often repetitive, amino acid sequences have been shown to act as enzyme mimetics. − Although, in general terms, they are catalytically less efficient than modern enzymes, the modularity, flexible design, stability, and reusability of these nanozymes endow them with advantages, , relative to their natural counterparts, including lower synthesis and modification costs.…”