Vanadium-nickel mixed oxides supported on TiO 2 (anatase) were prepared by wet impregnation using ammonium metavanadate and nickel nitrate aqueous solution. The performance of as-prepared samples in catalytic dichloromethane (DCM) combustion was investigated, and their physicochemical properties were characterized in detail by X-ray diffraction, N 2 physisorption, H 2 temperature-programmed reduction, NH 3 temperature-programmed desorption, and Raman spectroscopy analyses. Results showed DCM combustion activity over V-Ni/TiO 2 catalyst was superior to that of V 2 O 5 /TiO 2 and NiO/TiO 2 catalysts. DCM could be completely converted into CO 2 , HCl, and a little amount of CO over Ni-V/TiO 2 catalyst at 350 C, the toxic by-products, such as CH 3 Cl, aldehydes and phosgene could not be observed by online IR spectroscopy. The high catalytic activity, selectivity, and stability of V-Ni/TiO 2 catalyst could be due to the good oxidative dehydrogenation ability (ODH), the good reducibility of active oxygen species, and suitable strength of Lewis acidic sites upon introduction of nickel oxide.