Catalytic multimolecular reactions of 1,3-dicarbonyl CH acids with CH2O and S- and N-nucleophiles

Ахметова, В. Р.; Akhmadiev, Nail S.; Ибрагимов, А. Г.

doi:10.1007/s11172-017-1495-3

Cited by 8 publications

(2 citation statements)

References 31 publications

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“…According to the data, the uninhibited sample had the maximum corrosion current density. However, when the inhibitor concentration rises, so does the corrosion current density, I corr (μA cm −2 All of this suggests that as the concentration of the inhibitor increases, so does its efficacy [17][18][19][20][21][22][23]. Adsorption of sulfur atoms in inhibitors (D, E, and F) on the steel surface, and surfactants that represent the CR, is referred to as dropping the CR (E and F).…”

Section: Potentiodynamic Polarization Studiesmentioning

confidence: 99%

Green Synthesis of New Heterocyclic Surfactant Compounds by Multicomponent Reactions and Their Antibacterial and Corrosion Inhibitor, Study on Carbon Steel Alloy in Acid Media 2 M HCl

Al-Hilfi,

Al-Ameri,

Al-Asadi

2023

Indones. J. Chem.

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Heterocyclic 1,4-di(1,3,5-dithiazinan-5-yl)benzene (D) and two heterocyclic-cationic Gemini surfactant 5,5'-(1,4-phenylene)bis(5-decyl-1,3,5-dithiazinan-5-ium)bromide (E) and 5,5'-(1,4-phenylene)bis(5-tetradecyl-1,3,5-dithiazinan-5-ium)bromide (F) were prepared and identified by FTIR, 1H-NMR spectroscopies, and GC–MS. Then, they were tested as corrosion inhibitors against carbon steel corrosion in 2.0 M aggressive HCl medium at 25 and 50 °C. They have different carbon chain tails, i.e., E (10 carbons), and F (14 carbons). These new heterocyclic and surfactant categories as corrosion inhibitors. The corrosion process has been studied electrochemically (Tafel Plot). The inhibition efficiency clarified that the decrease in IE(%) is in the order of F > E > D. The biological activity of compounds D and F was investigated using the aforementioned drilling procedure with a cork drill. At a dosage of 3000 mcg/mL, the biological action of compound D demonstrated effective resistance against the two types of negative bacteria. The cation has a diameter of 20 mm against E. coli and 19 mm against S. epidermis bacteria. At the same concentration, the chemical F is solely effective against E. coli with an inhibition diameter of 14 mm.

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Section: Potentiodynamic Polarization Studiesmentioning

confidence: 99%

Green Synthesis of New Heterocyclic Surfactant Compounds by Multicomponent Reactions and Their Antibacterial and Corrosion Inhibitor, Study on Carbon Steel Alloy in Acid Media 2 M HCl

Al-Hilfi,

Al-Ameri,

Al-Asadi

2023

Indones. J. Chem.

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“…We have previously reported the one-pot effective synthesis of α,ω- bis (1,3-diketone-2-ylmethylsulfanyl)alkanes, 20 which are promising precursors for methylsulfanyl substituted α,ω- bis -pyrazoles with pronounced inhibitory effects on alpha-amylase activity. 21 - 23 …”

Section: Introductionmentioning

confidence: 99%

Synthesis of Bis(Isoxazol-4-Ylmethylsulfanyl)Alkanes and Some Metal Complexes as a Hepatoprotective Agents

Ахметова

Galimova

et al. 2018

Adv Pharm Bull

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Purpose: This research is devoted to designing the synthesis of sulfanyl-substituted 3,5-dimethylisoxazoles, which contain structural analogues of the SAM drug in the molecule. SAM (S-adenosyl-L-methionine), formed in the biosynthetic process, is used as an effective hepatoprotective drug. Complexation and hepatoprotective properties of the combinatorial series of bis(isoxazolylsulfanyl)ethane have been studied.Methods: Bis(isoxazol-4-ylmethylsulfanyl)alkanes were synthesized using the one-pot method. The structures of compounds were established by one-dimensional (1H,13C) and two-dimensional (COSY, HCQS, HMBC) NMR spectroscopy, mass-spectrometry and X-ray diffraction. The biological activity of the combinatorial series of sulfanyl derivatives of diketones, azoles and their metal complexes has been studied by in vivo method. Simulation of the animal associated processes was carried out in accordance with the principles of bioethics. Screening studies of hepatoprotective activity were carried out in a model of acute CC14 intoxication after a single injection intraperitoneally as a 50% solution in olive oil. The pharmacologically known hepatoprotective drug SAM served as a control.Results: Two-step synthesis of novel α,ω-bis(isoxazol-4-ylmethylsulfanyl)alkanes was carried out via the multicomponent reaction between 2,4-pentandione, CH2O and α,ω-dithiols, then the resulting α,ω-bis(1,3-diketone-2-ylmethylsulfanyl)alkanes were transformed by hydroxyl amine to obtain bis-isoxasole derivatives. Promising precursor 1,2-bis(isoxazol-4-ylmethylsulfanyl)ethane was converted to metal complexes by interaction with PdCl2 or CuCl. The obtained compounds were found to be practically non-toxic compounds (1001 – 3000 mg/kg) according to the classification of K.K. Sidorov, but copper complex refers to low-toxic compounds substances (165 mg/kg). Compounds of sulfanyl ethane series demonstrate hepatoprotective activity.Conclusion: Palladium(II) complex being almost non-toxic possesses hepatoprotective activity comparable to the drug like SAM.

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Synthesis and Biological Evaluation of 1,3,5-Dithiazinanes: Synthesis, Stereochemistry and Applications

Akhmetova,

Akhmadiev

2024

S-Heterocycles

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Catalytic multimolecular reactions of 1,3-dicarbonyl CH acids with CH2O and S- and N-nucleophiles

Cited by 8 publications

References 31 publications

Green Synthesis of New Heterocyclic Surfactant Compounds by Multicomponent Reactions and Their Antibacterial and Corrosion Inhibitor, Study on Carbon Steel Alloy in Acid Media 2 M HCl

Green Synthesis of New Heterocyclic Surfactant Compounds by Multicomponent Reactions and Their Antibacterial and Corrosion Inhibitor, Study on Carbon Steel Alloy in Acid Media 2 M HCl

Synthesis of Bis(Isoxazol-4-Ylmethylsulfanyl)Alkanes and Some Metal Complexes as a Hepatoprotective Agents

Synthesis and Biological Evaluation of 1,3,5-Dithiazinanes: Synthesis, Stereochemistry and Applications

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