Abstract:DcsB, an enzyme produced from the d‐cycloserine biosynthetic gene cluster, displays moderate similarity to arginase in the sequence and three‐dimensional structure. Arginase is a ubiquitous enzyme hydrolyzing l‐arginine to generate l‐ornithine and urea, whereas DcsB hydrolyzes Nω‐hydroxy‐l‐arginine (l‐NOHA), an arginase inhibitor, to generate l‐ornithine and hydroxyurea. We determined the crystal structure of DcsB associated with l‐ornithine and that with the tetrahedral derivative of 2(S)‐amino‐6‐boronohexano… Show more
Complex regulatory mechanisms govern daptomycin biosynthesis in Streptomyces roseosporus. Ten regulatory genes modulate transcription of daptomycin biosynthetic genes from a single promoter, and translation is coordinated by translational coupling.
Complex regulatory mechanisms govern daptomycin biosynthesis in Streptomyces roseosporus. Ten regulatory genes modulate transcription of daptomycin biosynthetic genes from a single promoter, and translation is coordinated by translational coupling.
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