Catalytic ortho C–H methylation and trideuteromethylation of arylthianthrenium salts via the Catellani strategy

Abstract

We reported a Pd/NBE cooperative catalyzed ortho C−H methylation and trideuteromethylation of arylthianthrenium salts, enabling the efficient synthesis of a wide variety of (trideutero)methylated arenes in moderate to good yields....

Modular Synthesis of Polysubstituted α-Phosphorylated Arenes via the Catellani Strategy

“…Furthermore, Yang and colleagues described a Pd­(II)-catalyzed, NBE-directed C–H phosphormethylation of indole to synthesize α-phosphorylated indoles. With our ongoing interest in the Catellani-type reaction, herein, we present a Pd/NBE-catalyzed ortho -C–H phosphomethylation of aryl iodides with XCH 2 P­(O)­RR′. Additionally, we successfully realized ipso -alkenylation, hydrogenation, cyanation, methylation, and arylation simultaneously, establishing a robust method for the modular synthesis of polysubstituted α-phosphorylated arenes (Scheme c).…”