Squalanei sa ni mportant ingredient in the cosmetic, nutraceutical, andp harmaceutical industries. It has also been used as am odel compound for the hydrocracking of crude and microalgae oil. Thus, as eries of green heterogeneousm etal catalysts were prepared to achievec omplete hydrogenation of highly unsaturated squalene into squalane. Surfacem odification of the clay and metal intercalation simultaneously occurred during wet impregnation. The Pd-nanoparticles-intercalated clay with ad ominating Pd(111)f acet showed the highest reactivity and selectivity.T he catalystw as stable with very low Pd leaching( % 0.03 ppm) and was recyclable withoutl osing any significant catalytic activity.The cost effectiveness ande asy availability of clays and claybased materials make them good choices as catalysts for the development of green methodsf or various chemical transformations.[1] Clay-based metal catalysts are preferred over metal catalysts owing to the advantagesa ssociated with the clays. [1b] Easy replacement of the interlamellarc ations in clays provides furtherp ossibilities to incorporate other cations or small molecules. Thus,s everal properties such as acidity,p ore size, and surfacea rea can be modified to influence catalytic performance. Naturally occurring clays can be modified either by physicalo rc hemical modification.[2] The treatment of natural montmorillonite clay with mineral acid is important for its improvedadsorption and catalytic properties. [3] The hydrogenation of unsaturated CÀCb onds by using heterogeneous catalysts [4] is an important industrial process.[5]Amongt hese processes, the chemoselective hydrogenation of highly unsaturated all-trans linear squalene into squalane is highly desirable. [6] Squalane is an exceptionale mollient with the distinct ability to penetrate human skin without feeling greasy and without harmful effects. [7] It is widely used in the cosmetic,n utraceutical, and pharmaceutical industries.[8] Recently,s qualane has drawn significant attentiona sahydrocracking model for crude and microalgae oil. [9] The hydrogenationo fs qualene was reported by Tsujimoto [10] in 1916 by using al arge amount of ap latinum catalyst in diethyl ether under H 2 pressure and was later reportedb yC hapman [11] in 1917 without any solvent at 190 8Ca nd under atmospheric H 2 pressure. An unsupported Raney-nickel catalystw as also used.[12] The industrial method for the hydrogenation of squalenei nto squalane involves an ickel-Kieselguhr catalyst under 4bar (1 bar = 0.1 MPa)o fH 2 pressure at 200 8C.[13] However,e xtensive purification is required to remove most of the nickel that leaches into the squalane product to meet the maximum acceptable levels of toxic nickel compounds. In one report, the reactiono ver Ni-based platinum catalysts resulted in extensive bond migration and dehydrogenation of squalene.[14] Phytosqualane was obtained [15] from trans-b-farnesene.[16] Recently,a ni mpressive advancementw as made by Pagliaroa nd co-workers, [17] who used SiliaCatPd 0 ,a no rganosilica ...