Catalytic enantioselective direct Michael additions of ketones to alkylidene malonates

Selective Michael additions to alkylidenemalonates using thiourea-based bifunctional organocatalysts

“…26 In fact the majority of reports to date detailing organocatalytic Michael reactions involving alkylidenemalonate acceptors have employed covalent catalysts to promote the reaction. 3,27 To the best of our knowledge, Zhao and co-workers reported the first H-bonding bifunctional organocatalysed Michael addition to an alkylidenemalonate in 2008.…”

1,2,3-Triazolium Salts as a Versatile New Class of Ionic Liquids

“…Cyclopentanone is known to be a less striking substrate for Michael additions to trans-β-nitrostyrene. It often gives enantioselectivity of around 50 % and low yield products after prolonged reaction times Betancort, Sakthivel et al 2001). …”

1,3-Dicarbonyl compounds in stereoselective domino and multicomponent reactions

“…The Michael acceptor (the arylidene malonate 141) was formed in situ by a Knoevenagel reaction catalyzed by proline between benzaldehyde and diethylmalonate(Scheme 53). 111 Proline then catalyzed the enantioselective Michael addition of acetone to the akylidene malonate 141. At the time of the development of this reaction, organocatalysis was in its infancy which justify the moderate yield and selectivity observed.…”