Catalytic degradation ofβ–hematin (malaria biomaker) using some selected metal oxide nanoparticles

Abstract

In this study, metal oxide (MO) nanoparticles were synthesized using a microwave and chemical methods and characterized using spectroscopic and microscopic techniques such as scanning electron microscopy (SEM), UV-vis spectroscopy, FTIR spectroscopy and Zeta potential analysis. The sensitivity (growth of inhibition) and catalytic degradation study of the MO nanoparticles with malaria biomarker (β-Hematin) and cultured Salmonella typhi was established. Both the chemical and microwave synthesized metal oxide nanoparticles exhibited effective potential to degrade the malaria biomarker at different degree and to its less active by-product. However, in most cases, microwave synthesized nanoparticles performed better than their chemically synthesized counterparts. The synthesized nanoparticles show high antibacterial activity towards clinical pathogens and S. typhi and therefore can be used for sensor development for monitoring these microorganisms in biological fluids such as blood, and urine samples.

Current challenges and nanotechnology-based pharmaceutical strategies for the treatment and control of malaria

“…Metal oxide nanoparticles such as zinc oxide, silver nitrate, chloroauric acid, iron oxide, copper oxide, and aluminium oxide are being extensively used by researchers for various medical applications. Metal oxide nanoparticles prepared by chemical and microwave methods can degrade the β –hematin (biomarker for malaria) ( Obisesan et al, 2020 ). Silver and silver based formulations have been used for the treatment of several microbial infections since antiquity.…”